TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
- Product Name
- TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
- CAS No.
- 6089-04-9
- Chemical Name
- TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
- Synonyms
- 2-Propargyloxane;pent-4-ynoic acid;2-prop-2-ynoxyoxane;TIMTEC-BB SBB008982;(2S)-2-prop-2-ynoxyoxane;2-Propynyl 2-pyranyl ether;2-(Prop-2-yn-1-yloxy)oxane;2-prop-2-ynoxytetrahydropyran;Tetrahydropyran-2-yloxypropyne;2-(Propargyloxy)tetrahydropyran
- CBNumber
- CB1779468
- Molecular Formula
- C8H12O2
- Formula Weight
- 140.18
- MOL File
- 6089-04-9.mol
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Property
- Boiling point:
- 63-65 °C9 mm Hg(lit.)
- Density
- 0.997 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.458(lit.)
- Flash point:
- 139 °F
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Clear colorless to light yellow
- Specific Gravity
- 0.997
- InChI
- InChI=1S/C8H12O2/c1-2-6-9-8-5-3-4-7-10-8/h1,8H,3-7H2
- InChIKey
- RNRIMDSCBRDPLC-UHFFFAOYSA-N
- SMILES
- C1(OCC#C)OCCCC1
- CAS DataBase Reference
- 6089-04-9
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 11
- Safety Statements
- 26-27-28-36/37/39-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29329900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 300810
- Product name
- Tetrahydro-2-(2-propynyloxy)-2H-pyran
- Purity
- 98%
- Packaging
- 25g
- Price
- $78.3
- Updated
- 2025/07/31
- Product number
- 300810
- Product name
- Tetrahydro-2-(2-propynyloxy)-2H-pyran
- Purity
- 98%
- Packaging
- 100g
- Price
- $236.71
- Updated
- 2025/07/31
- Product number
- P1624
- Product name
- 2-(2-Propynyloxy)tetrahydropyran
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $146
- Updated
- 2025/07/31
- Product number
- 84241
- Product name
- PROPARGYLALCOHOLTHPETH
- Packaging
- 25g
- Price
- $89.14
- Updated
- 2021/12/16
- Product number
- P838445
- Product name
- 2-(2-Propynyloxy)tetrahydropyran
- Packaging
- 2.5g
- Price
- $140
- Updated
- 2021/12/16
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to light yellow liquid
Uses
Tetrahydro-2-(2-propynyloxy)-2H-pyran was used in preparation of 1,3-dienyl acetal.
Synthesis Reference(s)
Chemistry Letters, 6, p. 817, 1977
Organic Syntheses, Coll. Vol. 7, p. 334, 1990
Synthetic Communications, 19, p. 901, 1989 DOI: 10.1080/00397918908051010
General Description
The anion formed by metalation at the acetylenic carbon reacts with a variety of electrophiles.
Synthesis
110-87-2
107-19-7
6089-04-9
General procedure for the synthesis of O-THP propargyl alcohol (Compound 18) from 3,4-dihydro-2H-pyran and 2-propyn-1-ol: Compound 18 was prepared according to literature procedure. To a solution of propargyl alcohol 17 (2.6 mL, 44.6 mmol) and p-toluenesulfonic acid monohydrate (0.09 g, 0.5 mmol) in dichloromethane (45 mL) was added dropwise 3,4-dihydro-2H-pyran (4.3 mL, 46.8 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 5 min before slowly warming up to room temperature and continued stirring for 1 h. The reaction mixture was then purified with aqueous solution of saturated 2H-pyran (4.3 mL). Subsequently, the reaction mixture was washed with saturated sodium bicarbonate solution (30 mL) and the aqueous layer was extracted with dichloromethane (45 mL). The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give compound 18 (6.1 g, 97.2% yield) as a yellow oil. Thin layer chromatography (TLC) Rf = 0.30 (hexane/ether, 95:5). 1H NMR (400 MHz, CDCl3): δ = 1.50-1.67 (m, 4H), 1.70-1.89 (m, 2H), 2.41 (t, J = 2.4 Hz, 1H), 3.52-3.57 (m, 1H), 3.82-3.87 (m , 1H), 4.27 (ddd, J = 2.4 Hz, 11.3 Hz, 15.8 Hz, 2H), 4.83 (t, J = 3.4 Hz, 1H). 13C NMR (100 MHz, CDCl3): δ = 19.0, 25.3, 30.2, 53.9, 61.9, 74.0, 79.7, 96.8. mass spectra (MS-CI): m/z calculated values. ): m/z calculated value C8H12O2 [M + H]+, 141; measured value: 141. The synthesis of this compound has been reported in the literature.
References
[1] Synlett, 2003, # 14, p. 2163 - 2166
[2] Tetrahedron, 2010, vol. 66, # 25, p. 4573 - 4576
[3] Synthesis, 2005, # 19, p. 3293 - 3296
[4] Journal of the Chinese Chemical Society, 2007, vol. 54, # 2, p. 525 - 532
[5] Journal of Organic Chemistry, 2009, vol. 74, # 4, p. 1531 - 1540
TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN manufacturers
- Product
- TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9
- Price
- US $80.00-800.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-13
- Product
- TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9
- Price
- US $10.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-28
- Product
- TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN 6089-04-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-29