Adverse Reactions
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Medetomidine

Adverse Reactions
Product Name
Medetomidine
CAS No.
86347-14-0
Chemical Name
Medetomidine
Synonyms
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;DoMtor;CS-849;Medetomidin;Medetomidine;Medetomidina;Medetomidinum;dl-Medetomidine;Medetomidine-D5;Medetomidine, BR
CBNumber
CB0951588
Molecular Formula
C13H16N2
Formula Weight
200.28
MOL File
86347-14-0.mol
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Medetomidine Property

Boiling point:
381.9±11.0 °C(Predicted)
Density 
1.053
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO
pka
14.29±0.10(Predicted)
form 
Powder
color 
White to off-white
InChI
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
InChIKey
CUHVIMMYOGQXCV-UHFFFAOYSA-N
SMILES
C1NC(C(C2=CC=CC(C)=C2C)C)=CN=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

H336May cause drowsiness or dizziness

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0734
Product name
Medetomidine
Purity
99.97%
Packaging
10mg
Price
$80
Updated
2021/12/16
ApexBio Technology
Product number
A3592
Product name
Medetomidine
Packaging
5mg
Price
$88
Updated
2021/12/16
AK Scientific
Product number
3506AC
Product name
Medetomidine
Packaging
25mg
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-0734
Product name
Medetomidine
Purity
99.97%
Packaging
50mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
J55251
Product name
4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole
Packaging
250mg
Price
$245
Updated
2021/12/16
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Medetomidine Chemical Properties,Usage,Production

Adverse Reactions

As with all α2-agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists. Incidents of prolonged sedation, bradycardia, cyanosis, vomiting, apnea, death from circulatory failure with severe congestion of lungs, liver, kidney and recurrence of sedation after initial recovery have been reported.

Description

Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.

Uses

Analgesic (veterinary); sedative (veterinary).

Uses

Medetomidine is used in method for synthesizing Medetomidine using 2,3-Dimethylphenylmagnesium Bromide.

Indications

Medetomidine Hydrochloride is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required. The IV route of administration is more efficacious for dental care.

Definition

ChEBI: Medetomidine is a member of imidazoles.

Clinical Use

Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine.

Side effects

Bradycardia with occasional atrioventricular blocks will occur together with decreased respiratory rates. Body temperature is slightly or moderately decreased. Urination typically occurs during recovery at about 90 to 120 minutes posttreatment. In approximately 10% of treated dogs, occasional episodes of vomiting occur between 5 to 15 minutes posttreatment. An increase in blood glucose concentration is seen due to α2-adrenoreceptor-mediated inhibition of insulin secretion.

Veterinary Drugs and Treatments

Medetomidine is labeled for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations and procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures not requiring intubation. The manufacturer recommends the IV route of administration for dental procedures. Medetomidine has also been used in cats, primarily in Europe. But there is apparently much less data available to evaluate its use; caution is advised.

Precautions

In extremely nervous or excited dogs, levels of endogenous catecholamines are high due to the animal’s state of agitation. The pharmacological response elicited by α2-agonists (e.g., medetomidine) in such animals is often reduced, with depth and duration of sedative/analgesic effects ranging from slightly diminished to nonexistent. Highly agitated dogs should therefore be put at ease and allowed to rest quietly prior to receiving Medetomidine Hydrochloride. Allowing dogs to rest quietly for 10 to 15 minutes after injection may improve the response to Medetomidine Hydrochloride. In dogs not responding satisfactorily to treatment with Medetomidine Hydrochloride, repeat dosing is not recommended.

Medetomidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Medetomidine Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
19943
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
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View Lastest Price from Medetomidine manufacturers

Dorne Chemical Technology co. LTD
Product
Medetomidine 86347-14-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Jinan Million Pharmaceutical Co., Ltd
Product
Medetomidine 86347-14-0
Price
US $6.00/kg
Min. Order
1kg
Purity
99.56
Supply Ability
60 tons
Release date
2024-09-28
Wuhan Haorong Biotechnology Co.,Ltd
Product
Medetomidine 86347-14-0
Price
US $1.00/KG
Min. Order
0.01KG
Purity
99%
Supply Ability
2000 tons
Release date
2024-09-26

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