(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
- Product Name
- (S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
- CAS No.
- 313706-15-9
- Chemical Name
- (S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
- Synonyms
- (S)-Methyl 1-Boc-pyrrolid...;(R)-1-tert-butyl 3-methyl pyrrolidine-;(S)-1-Boc-pyrrolidine-1,3-dicarboxylate;Methyl (S)-1-Boc-pyrrolidine-3-carboxylate;(S)-Methyl 1-Boc-pyrrolidine-3-carboxylate;1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate;(S)-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;(S)-1-1-Boc-pyrrolidine-3-carboxylic acid methyl ester;(S)-1-tert-butyl 3-Methyl pyrrolidine-1,3-dicarboxylate;(R)-1-tert-butyl 3-methyl pyrrolidine-1,3-dicarboxylate
- CBNumber
- CB0970875
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 313706-15-9.mol
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Property
- Boiling point:
- 288.6±33.0 °C(Predicted)
- Density
- 1.120±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.65±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 313706-15-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809983
- Product name
- (S)-1-tert-Butyl3-MethylPyrrolidine-1,3-dicarboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB151297
- Product name
- 1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate
- Packaging
- 50mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 4H58-1-A4
- Product name
- Methyl (S)-1-Boc-pyrrolidine-3-carboxylate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-B0425
- Product name
- (S)-1-Boc-pyrrolidine-1,3-dicarboxylate
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB151297
- Product name
- 1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
140148-70-5
74-88-4
313706-15-9
To a solution of (S)-1-BOC-pyrrolidine-3-carboxylic acid (863 mg, 4.01 mmol) and K2CO3 (829 mg, 6.00 mmol) in anhydrous DMF (8 mL) was added iodomethane (300 μL, 4.82 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, water was added and extracted three times with ether (Et2O). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (eluent: n-hexane/ethyl acetate = 3:1) to afford the target product (S)-1-Boc-3-carboxypyrrolidinium methyl ester (916 mg, 100%) as a colorless oil. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.70 (3H, s), 3.65-3.28 (4H, m), 3.10-2.98 (1H, m), 2.18-2.05 (2H, m), 1.45 (9H, s). lRMS (ESI, [M + Na]+) showed the molecular ion peak as 252.1.
References
[1] Tetrahedron, 2012, vol. 68, # 23, p. 4418 - 4428
[2] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0769
[3] Patent: WO2016/112088, 2016, A1. Location in patent: Paragraph 0749
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Suppliers
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