1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
- Product Name
- 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
- CAS No.
- 69304-37-6
- Chemical Name
- 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
- Synonyms
- TIPSCL;1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE;TIPDSICL2;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;DK365;DK870;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro;1,1,3,3-TETRAISOPROPYL-1,3-DICH;Bis(chlorodiisopropylsilyl) ether
- CBNumber
- CB1100268
- Molecular Formula
- C12H28Cl2OSi2
- Formula Weight
- 315.43
- MOL File
- 69304-37-6.mol
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Property
- Boiling point:
- 70 °C0.5 mm Hg(lit.)
- Density
- 0.986 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.454(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
- form
- Oil
- color
- Colourless
- Specific Gravity
- 0.986
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- Sensitive
- Moisture Sensitive
- BRN
- 1934216
- InChI
- InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
- InChIKey
- DDYAZDRFUVZBMM-UHFFFAOYSA-N
- SMILES
- [Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C
- CAS DataBase Reference
- 69304-37-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10-21
- Hazard Note
- Corrosive
- TSCA
- No
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 337005
- Product name
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
- Purity
- 97%
- Packaging
- 1g
- Price
- $27.06
- Updated
- 2024/03/01
- Product number
- 337005
- Product name
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
- Purity
- 97%
- Packaging
- 5g
- Price
- $133
- Updated
- 2024/03/01
- Product number
- D1608
- Product name
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- D1608
- Product name
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $348
- Updated
- 2024/03/01
- Product number
- L11171
- Product name
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%
- Packaging
- 5g
- Price
- $202
- Updated
- 2024/03/01
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Physical properties
bp 70°C/0.5 mmHg; d 0.986 g cm?3.
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of
furanose nucleosides;protecting group for carbohydrates;3,4
protecting group reagent for open-chain polyhydroxy compounds;
preparation of cyclic bridged peptides.
The reagent
design was based upon the fact that triisopropylsilyl chloride
reacts 1000 times faster with primary alcohols than secondary
alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the
reagent initially silylates at the 5'-position. This is then followed
by intramolecular reaction with the secondary alcohol at the
3'-position to give the doubly protected derivative (eq 1).
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.
Preparation
can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE manufacturers
- Product
- 1,3-dichlorotetraisopropyldisiloxane 69304-37-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10tons/month
- Release date
- 2024-03-25
- Product
- 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11