ChemicalBook > CAS DataBase List > 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Product Name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
CAS No.
69304-37-6
Chemical Name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
Synonyms
TIPSCL;1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE;TIPDSICL2;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;DK365;DK870;DKSI013;DKFELEX0228;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro
CBNumber
CB1100268
Molecular Formula
C12H28Cl2OSi2
Formula Weight
315.43
MOL File
69304-37-6.mol
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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Property

Boiling point:
70 °C0.5 mm Hg(lit.)
Density 
0.986 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.454(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
form 
Oil
color 
Colourless
Specific Gravity
0.986
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
Sensitive 
Moisture Sensitive
BRN 
1934216
InChI
InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
InChIKey
DDYAZDRFUVZBMM-UHFFFAOYSA-N
SMILES
[Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C
CAS DataBase Reference
69304-37-6(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-28-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive
TSCA 
No
HazardClass 
8
PackingGroup 
II
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
337005
Product name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
Purity
97%
Packaging
1g
Price
$27.06
Updated
2024/03/01
Sigma-Aldrich
Product number
337005
Product name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
Purity
97%
Packaging
5g
Price
$133
Updated
2024/03/01
TCI Chemical
Product number
D1608
Product name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
Purity
>97.0%(GC)
Packaging
5g
Price
$116
Updated
2024/03/01
TCI Chemical
Product number
D1608
Product name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
Purity
>97.0%(GC)
Packaging
25g
Price
$348
Updated
2024/03/01
Alfa Aesar
Product number
L11171
Product name
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%
Packaging
5g
Price
$202
Updated
2024/03/01
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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Physical properties

bp 70°C/0.5 mmHg; d 0.986 g cm?3.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).

Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.

Preparation

can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Suppliers

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View Lastest Price from 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE 69304-37-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

69304-37-6, 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxaneRelated Search:

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  • 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANE
  • 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
  • 1,3-DICHLOROTETRAISOPROPYLDISILOXANE
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  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane,96%
  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane ,97%
  • chloro-(chloro-dipropan-2-yl-silyl)oxy-dipropan-2-yl-silane
  • 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-
  • 1,3-Dichloro-1,1,3,3-tetraisopropoxydisiloxane
  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
  • Disiloxane, 1,3-dichloro-1,1,3,3-tetrakis(1-methylethyl)-
  • TIPSCL
  • chloro({[chlorobis(propan-2-yl)silyl]oxy})bis(propan-2-yl)silane
  • 1,1,3,3-TETRAISOPROPYL-1,3-DICH
  • JACS-69304-37-6
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  • 1,3-Dichloro-1,1,3,3-tetrakis(prop-2-yl)disiloxane
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  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 96% 5ML
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  • 2,6-DiMethyl-3,5-dichloro
  • 1,1,3,3-tetraisopropyldisiloxanylidene-dichloride
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  • TIPDSICL2
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  • 1,1,3,3-Tetraisopropyl-1,3-dichlorodisiloxane 〔1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane〕
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  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane[HydroxylProtectingAgent]&gt
  • chloro-[chloro(diisopropyl)silyl]oxy-diisopropyl-silane
  • 1,3-Dichloro-1,1,3,3-tetrakis(1-methylethyl)disiloxane
  • DK365
  • DK870
  • 1,3-DICHLORO-1,1,3,3- TETRAISOPROPYLDISILOXANE TIPDSiCl2
  • 1,3-dichloro-1,1,3,3-tetraisopropyldimethylsiloxane
  • 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane（TIPSCI）
  • 1,3-DICHLORO-1,1,3,3- TETRAISOPROPYLDISILOXANE6
  • DKFELEX0228
  • DKSI013
  • 69304-37-6
  • C12H28Si2Cl2O
  • CH32CH2SiClOSiClCHCH322
  • C12H28Cl2OSi2
  • CH32CH2SiClOClSiCHCH322
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Synthetic Reagents
  • Silicon-Based
  • Protection & Derivatization Reagents (for Synthesis)
  • Siloxanes
  • Si-O Compounds
  • Si (Classes of Silicon Compounds)
  • Silicon Compounds (for Synthesis)
  • Si-Cl Compounds