Indisulam
- Product Name
- Indisulam
- CAS No.
- 165668-41-7
- Chemical Name
- Indisulam
- Synonyms
- D04522;E-7070;ER-35744;INDISULAM;IndisulaM (E7070);INDISULAM iMpurity;Indisulam【SML1225】;E7070;ER-35744;D04522;Indisulam >=98% (HPLC);Indisulam, 10 mM in DMSO
- CBNumber
- CB11011305
- Molecular Formula
- C14H12ClN3O4S2
- Formula Weight
- 385.85
- MOL File
- 165668-41-7.mol
Indisulam Property
- Melting point:
- 242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 668.9±65.0 °C(Predicted)
- Density
- 1.663±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)
- form
- powder
- pka
- 8.14±0.30(Predicted)
- color
- white to beige
- InChI
- InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
- InChIKey
- SETFNECMODOHTO-UHFFFAOYSA-N
- SMILES
- C1(S(NC2C3=C(C=CC=2)C(Cl)=CN3)(=O)=O)=CC=C(S(N)(=O)=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1225
- Product name
- Indisulam
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $142.5
- Updated
- 2025/07/31
- Product number
- SML1225
- Product name
- Indisulam
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $594
- Updated
- 2025/07/31
- Product number
- 22759
- Product name
- Indisulam
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22759
- Product name
- Indisulam
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 22759
- Product name
- Indisulam
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
Indisulam Chemical Properties,Usage,Production
Uses
Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2].
Definition
ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.
Biochem/physiol Actions
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
in vivo
Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models[1].
| Animal Model: | Female BALB/c nu/nu mice aged 7 weeks (HCT116 colon, LX-1 lung, SW620 colon, HCT115 colon, PC-9 lung, DLD-1 colon and WiDr colon models)[1]. |
| Dosage: | 12.5, 25, 50 (100) mg/kg. |
| Administration: | IV daily for 4 days. |
| Result: | Exhibited anti-tumor activity. |
storage
Store at -20°C
References
[1] Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. DOI:10.1016/s0959-8049(01)00275-1
[2] Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. DOI:10.1016/j.bmcl.2003.09.062
Indisulam Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Indisulam manufacturers
- Product
- Indisulam 165668-41-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Indisulam 165668-41-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-13