ChemicalBook > CAS DataBase List > Indisulam

Indisulam

Product Name: Indisulam
CAS No.: 165668-41-7
Chemical Name: Indisulam
Synonyms: D04522;E-7070;ER-35744;INDISULAM;IndisulaM (E7070);INDISULAM iMpurity;Indisulam【SML1225】;E7070;ER-35744;D04522;Indisulam >=98% (HPLC);Indisulam, 10 mM in DMSO
CBNumber: CB11011305
Molecular Formula: C14H12ClN3O4S2
Formula Weight: 385.85
MOL File: 165668-41-7.mol

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Indisulam Property

Melting point:: 242-243 °C (decomp)(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:: 668.9±65.0 °C(Predicted)
Density: 1.663±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)
form: powder
pka: 8.14±0.30(Predicted)
color: white to beige
InChI: InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChIKey: SETFNECMODOHTO-UHFFFAOYSA-N
SMILES: C1(S(NC2C3=C(C=CC=2)C(Cl)=CN3)(=O)=O)=CC=C(S(N)(=O)=O)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1225
Product name: Indisulam
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $142.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1225
Product name: Indisulam
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $594
Updated: 2025/07/31

Cayman Chemical

Product number: 22759
Product name: Indisulam
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22759
Product name: Indisulam
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 22759
Product name: Indisulam
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

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Indisulam Chemical Properties,Usage,Production

Uses

Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2].

Definition

ChEBI: Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.

Biochem/physiol Actions

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

in vivo

Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models^[1].

Animal Model:	Female BALB/c nu/nu mice aged 7 weeks (HCT116 colon, LX-1 lung, SW620 colon, HCT115 colon, PC-9 lung, DLD-1 colon and WiDr colon models)^[1].
Dosage:	12.5, 25, 50 (100) mg/kg.
Administration:	IV daily for 4 days.
Result:	Exhibited anti-tumor activity.

storage

Store at -20°C

References

[1] Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. DOI:10.1016/s0959-8049(01)00275-1
[2] Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. DOI:10.1016/j.bmcl.2003.09.062

Indisulam Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Indisulam manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Indisulam 165668-41-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: Indisulam 165668-41-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-13

165668-41-7, IndisulamRelated Search:

Chlorantraniliprole Benzenesulfonamide Sulfanilamide Amlodipine Besylate (S)-Amlodipine Phenylacetyl chloride Diphenyl chlorophosphate Hydrochlorothiazide 2-CHLOROINDOLE 3-CHLORO-1H-INDOL-7-AMINE 7-Aminoindole Indisulam Difluorochloromethane

INDISULAM

1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-

N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

E-7070

ER-35744

IndisulaM (E7070)

IndisulaM (E7070) (ER-35744)

N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide

D04522

E7070;ER-35744;D04522

1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-

Indisulam >=98% (HPLC)

N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide

E-7070,Indisulam,Carbonic Anhydrase,Inhibitor,Carbonate dehydratase,E7070,inhibit

INDISULAM iMpurity

Indisulam, 10 mM in DMSO

Indisulam【SML1225】

165668-41-7

C14H12ClN3O4S2