Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI)
- Product Name
- Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 56267-48-2
- Chemical Name
- Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- TERT-BUTYL FURAN-3-YLCARBAMATE;N-Boc-3-furanamine;3-(Boc-amino)furan;Furan-3-tert-butylamine;tert-Butyl 3-furancarbamate;tert-butyl 3-furylcarbamate;ert-Butylfuran-3-ylcarbamate;3-Aminofuran, N-BOC protected;tert-butyl N-(3-furyl)carbamate;tert-Butylfuran-3-ylcarbamate,98%
- CBNumber
- CB11050173
- Molecular Formula
- C9H13NO3
- Formula Weight
- 183.2
- MOL File
- 56267-48-2.mol
Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) Property
- Melting point:
- 135-137 °C
- Boiling point:
- 205.3±13.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.52±0.70(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C9H13NO3/c1-9(2,3)13-8(11)10-7-4-5-12-6-7/h4-6H,1-3H3,(H,10,11)
- InChIKey
- SBFLPNJYWRKWFT-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1C=COC=1
Safety
- HS Code
- 2932190090
N-Bromosuccinimide Price
- Product number
- FB134008
- Product name
- tert-Butyl 3-furylcarbamate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR43662
- Product name
- 3-Aminofuran,N-BOCprotected
- Purity
- 95+%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- FB134008
- Product name
- tert-Butyl 3-furylcarbamate
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 4H51-1-2T
- Product name
- 3-Aminofuran, N-Boc protected
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- FB134008
- Product name
- tert-Butyl 3-furylcarbamate
- Packaging
- 1g
- Price
- $182
- Updated
- 2021/12/16
Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
488-93-7
75-65-0
56267-48-2
General procedure for the synthesis of tert-butyl furan-3-yl carbamate from 3-furoic acid and tert-butanol: To a solution of toluene (800 mL) containing 3-furoic acid (54.4 g, 485 mmol), triethylamine (105 mL, 753 mmol), and tert-butanol (25.2 mL, 786 mmol) was added slowly and dropwise at 45 °C at room temperature diphenylphosphoryl azide (157.8 mL, 732 mmol) at 45 °C. After dropwise addition, the reaction mixture was heated to reflux for 6 hours, followed by stirring at room temperature overnight. Upon completion of the reaction, the reaction mixture was diluted with water (1000 mL) and extracted twice with ethyl acetate (1000 mL). The organic layers were combined, washed sequentially with water (800 mL) and brine (800 mL), decolorized by activated charcoal, dried, filtered and concentrated in vacuum to give a brown semi-solid product. The semi-solid product was crystallized by a solvent mixture of dichloromethane (300 mL) and hexane (600 mL) to finally obtain tert-butyl furan-3-yl carbamate (61.5 g, 78% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.71 (s, 1H), 7.30-7.24 (m, 1H), 6.43 (s, 1H), 6.27 (s, 1H), 1.75-1.32 (s, 9H).
References
[1] Patent: WO2010/14930, 2010, A2. Location in patent: Page/Page column 39
[2] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 77
[3] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 136-137
[4] Patent: WO2008/73785, 2008, A2. Location in patent: Page/Page column 163
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 22, p. 7815 - 7833
Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) Suppliers
- Tel
- --
- Fax
- --
- info@chemstep.com
- Country
- Europe
- ProdList
- 6143
- Advantage
- 51
View Lastest Price from Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) manufacturers
- Product
- tert-Butyl furan-3-ylcarbamate 56267-48-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06
- Product
- Carbamic acid, 3-furanyl-, 1,1-dimethylethyl ester (9CI) 56267-48-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2020-01-02