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furo[3,2-b]pyridine

Product Name
furo[3,2-b]pyridine
CAS No.
272-62-8
Chemical Name
furo[3,2-b]pyridine
Synonyms
4-Azabenzo[b]furan;furo[3,2-b]pyridine;Furo[3,2-b]pyridine,98%;4-Azabenzo[b]furan, 4-Aza-1-benzofuran
CBNumber
CB41515864
Molecular Formula
C7H5NO
Formula Weight
119.12
MOL File
272-62-8.mol
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furo[3,2-b]pyridine Property

Boiling point:
79-80℃ (12 Torr)
Density 
1.2g/ml
refractive index 
1.5753 (19℃)
storage temp. 
Inert atmosphere,Room Temperature
form 
liquid
pka
4.22±0.30(Predicted)
color 
Clear Colourless
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
F822570
Product name
Furo[3,2-b]pyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR17929
Product name
Furo[3,2-b]pyridine
Packaging
250mg
Price
$66
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-2M
Product name
Furo[3,2-b]pyridine
Packaging
250mg
Price
$72
Updated
2021/12/16
AK Scientific
Product number
Y8522
Product name
Furo[3,2-b]pyridine
Packaging
250mg
Price
$117
Updated
2021/12/16
Apolloscientific
Product number
OR17929
Product name
Furo[3,2-b]pyridine
Packaging
1g
Price
$163
Updated
2021/12/16
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furo[3,2-b]pyridine Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 665, 1986 DOI: 10.1002/jhet.5570230305

Synthesis

92671-70-0

272-62-8

PdCl2(PPh3)2 (1.4 g, 2.0 mmol) and CuI (0.4 g, 2.1 mmol) were dissolved in a solvent mixture of triethylamine (TEA, 100 mL) and tetrahydrofuran (THF, 200 mL) under nitrogen atmosphere. Subsequently, a solution of 2-bromo-3-acetoxypyridine (13.1 g, 60.6 mmol) and trimethylsilylacetylene (TMS-acetylene, 7.0 g, 71 mmol) in THF (100 mL) was added one time to the above solution. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution (50 mL) and methanol (50 mL). The mixture was continued to be stirred at 80 °C for 2 hours. After cooling to room temperature, it was extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by column chromatography to afford furo[3,2-b]pyridine (1.54 g, 21% yield).1H NMR (CDCl3, 400 MHz) δ 8.55 (m, 1H), 7.84 (m, 1H), 7.75 (m, 1H), 7.72 (m, 1H), 6.99 (m, 1H).

References

[1] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 144
[2] Patent: WO2005/51304, 2005, A2. Location in patent: Page/Page column 144

furo[3,2-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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furo[3,2-b]pyridine Suppliers

J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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Yancheng Schiemann Biological Technology Co.,Ltd
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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View Lastest Price from furo[3,2-b]pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-AZABENZO[B]FURAN 272-62-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
50kg
Release date
2025-06-24