Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
- Product Name
- Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
- CAS No.
- 478148-62-8
- Chemical Name
- Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
- Synonyms
- Furo[2,3-c]pyridine-5-carboxylic acid (9CI)
- CBNumber
- CB71048198
- Molecular Formula
- C8H5NO3
- Formula Weight
- 163.13
- MOL File
- 478148-62-8.mol
Furo[2,3-c]pyridine-5-carboxylic acid (9CI) Property
- Boiling point:
- 366.8±22.0 °C(Predicted)
- Density
- 1.455
- storage temp.
- 2-8°C
- pka
- 1.06±0.30(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F865315
- Product name
- Furo[2,3-C]pyridine-5-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 119205
- Product name
- Furo[2,3-c]pyridine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $429
- Updated
- 2021/12/16
- Product number
- CHM0392684
- Product name
- FURO[2,3-C]PYRIDINE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.62
- Updated
- 2021/12/16
- Product number
- 119205
- Product name
- Furo[2,3-c]pyridine-5-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1072
- Updated
- 2021/12/16
- Product number
- W6445
- Product name
- Furo[2,3-c]pyridine-5-carboxylicacid
- Packaging
- 5g
- Price
- $2786
- Updated
- 2021/12/16
Furo[2,3-c]pyridine-5-carboxylic acid (9CI) Chemical Properties,Usage,Production
Synthesis
478148-61-7
478148-62-8
The general procedure for the synthesis of furo[2,3-c]pyridine-5-carboxylic acid from furo[2,3-c]pyridine-5-carboxaldehyde was as follows: furo[2,3-c]pyridine-5-carboxaldehyde (850 mg, 5.8 mmol) was dissolved in 10 mL of dimethyl sulfoxide (DMSO). To this solution was added a 3 mL aqueous solution of potassium dihydrogen phosphate (KH2PO4, 221 mg, 1.6 mmol) followed by a 7 mL aqueous solution of sodium chlorite (NaClO2, 920 mg, 8.2 mmol). The reaction mixture was stirred for 3 h at room temperature. After completion of the reaction, the reaction mixture was diluted with 25 mL of water, the pH was adjusted to 10 with 2 N sodium hydroxide (NaOH) solution, and then extracted with ether (3 x 20 mL). The combined ether layers were discarded. The aqueous layer was adjusted to pH 3.5 with 10% aqueous hydrochloric acid (HCl) solution and then extracted with 10% methanol/dichloromethane (MeOH/CH2Cl2, 13 × 10 mL). The combined organic layers were dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to give a light-colored oil. Residual DMSO was removed at room temperature under a stream of nitrogen (N2) to give a white paste. The paste was dissolved in methanol (MeOH) and concentrated to dryness. The white solid was washed with ether and dried to give the crude furano[2,3-c]pyridine-5-carboxylic acid (94% yield). The compound with molecular formula C8H5NO3 was obtained by mass spectrometry (ESI) analysis with a mass-to-charge ratio (m/z) of 162.8 (M-H)-.
References
[1] Patent: US2003/153595, 2003, A1
[2] Patent: US2003/45540, 2003, A1
[3] Patent: WO2004/52894, 2004, A1. Location in patent: Page 36
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4425 - 4436
Furo[2,3-c]pyridine-5-carboxylic acid (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Furo[2,3-c]pyridine-5-carboxylic acid (9CI) manufacturers
- Product
- Furo[2,3-c]pyridine-5-carboxylic acid (9CI) 478148-62-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-02-20