Sulfamethoxypyridazine

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Sulfamethoxypyridazine

Product Name: Sulfamethoxypyridazine
CAS No.: 80-35-3
Chemical Name: Sulfamethoxypyridazine
Synonyms: Sulphamethoxypyridazine;Sulfamethoxypyridazine-d3;SMPZ;Paramid;Sulfametoxipiridazine;6-Sulfanilamido-3-methoxypyridazine;N1-(6-Methoxy-3-pyridazinyl)sulfanilamide;Durox;Kinex;Kynex
CBNumber: CB1107025
Molecular Formula: C11H12N4O3S
Formula Weight: 280.3
MOL File: 80-35-3.mol

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Sulfamethoxypyridazine Property

Melting point:: 182-183°
Boiling point:: 564.9±60.0 °C(Predicted)
Density: 1.3936 (rough estimate)
refractive index: 1.6200 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 6.7(at 25℃)
color: White to yellow
Water Solubility: 579.5mg/L(25 ºC)
Merck: 14,8919
BRN: 277076
CAS DataBase Reference: 80-35-3(CAS DataBase Reference)
NIST Chemistry Reference: Pyridazine, sulfamethoxy-(80-35-3)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 2
RTECS: WP0400000
F: 10
HS Code: 29350090
Toxicity: LD50 orally in mice: 1750 mg/kg, (Seki)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 46858
Product name: Sulfamethoxypyridazine
Purity: VETRANAL?, analytical standard
Packaging: 250mg
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: S0591
Product name: Sulfamethoxypyridazine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: S0591
Product name: Sulfamethoxypyridazine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 21875
Product name: Sulfamethoxypyridazine
Purity: ≥95%
Packaging: 5g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21875
Product name: Sulfamethoxypyridazine
Purity: ≥95%
Packaging: 10g
Price: $57
Updated: 2024/03/01

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Sulfamethoxypyridazine Chemical Properties,Usage,Production

Chemical Properties

White or slightly yellow crystalline powder; odorless, bitter taste; discolored when exposed to light. The product is slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; easily soluble in dilute hydrochloric acid or alkali hydroxide solution.

Uses

Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic with anti-inflammatory and antibacterial effects, mainly used for streptococcus, staphylococcus, Escherichia coli and other infections, especially for urinary tract infections.

Application

Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method.

Indications

This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.

Definition

ChEBI: Sulfamethoxypyridazine is a sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antiinfective agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor and a drug allergen. It is a member of pyridazines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide.

brand name

Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44.

World Health Organization (WHO)

Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial.

General Description

Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis.

Pharmaceutical Applications

3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim.

Synthesis

Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.

Sulfamethoxypyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sulfamethoxypyridazine manufacturers

Hebei Duling International Trade Co. LTD

Product: Sulfamethoxypyridazine 80-35-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000
Release date: 2023-01-06

Hebei Yanxi Chemical Co., Ltd.

Product: sulfamethoxypyridazine 80-35-3
Price: US $100.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-04

Hebei Mojin Biotechnology Co., Ltd

Product: Sulfamethoxypyridazine 80-35-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-06

80-35-3, SulfamethoxypyridazineRelated Search:

2-Methoxyethanol Glycine Anisole Sulfadiazine Pyridaphenthion 4-Methoxybenzoyl chloride Betaine Sulfanilamide N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO Aniline Thioridazine Sulfadimethoxine (Trifluoromethoxy)benzene ALTRENOGEST Sulfachloropyridazine sodium Sulfachoropyrazine sodium SULFACHLOROPYRIDAZINE 2-Aminobenzenesulfonamide

Sulfametoxipiridazine

Sulfanilamide, N<sup>1</sup>-(6-methoxy-3-pyridazinyl)-

Sulfapyridazine

Sulfdurazin

Sulfozona

Sulphamethoxypyridazine

Sultirene

Surirene

Vinces

Sulfamethoxopyridazine

SULFAMETHOXYPYRIDAZINE STANDARD SOLUTION

SULFAMETHOXYPYRIDAZINE VETRANAL, 250

sulfamethoxypyridazine solution

SULPHAMETHOXYPYRIDAZINE(SMP)

sulfadimoxine， SASP

N1-(6-methoxypyridazin-3-yl)sulphanilamide

Sulfamethoxyp

Sulfamethoxypyridazine Solution, 100ppm

sulfmethoxypyridazine

Sulphanyl acid N-(6-methoxypyridazin-3-yl) amide

4-Amino-N-(6-methoxy-3-pyridazinyl)benzenesulfonamide N-(6-Methoxy-3-pyridazinyl)sulfanilamide

Depovernil

Durox

Kineks

Kinex

Kynex

Lederkyn

Lentac

Lisulfen

Longin

Medicel

Midikel

Myasul

Mylosul

n(sup1)-(6-methoxy-3-pyridazinyl)-sulfanilamid

n(sup1)-(6-methoxy-3-pyridazinyl)sulfanilamide

N<sup>1</sup>-(6-Methoxy-3-pyridazinyl)sulfanilamide

Opinsul

Paramid

Paramid supra

paramidsupra

Petrisul

Piridolo

Quinoseptyl

Retamid

Retasulfin

RP 7522

rp7522

Slosul

SMPZ

Spofadazine

Sulfalex

N1-(6-Methoxy-3-pyridazinyl)sulfanilamide

7522RP

Exazol

Grosul

4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide

4-azanyl-N-(6-methoxypyridazin-3-yl)benzenesulfonamide