ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Property

Boiling point:

115-120°C/20mmHg

Density 

1.381±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Oil

color 

Clear Colourless to Pale Yellow

CAS DataBase Reference

107905-52-2

Safety

HS Code 

2931599090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Chemical Properties,Usage,Production

Chemical Properties

Colourless Liquid

Uses

A wittig reagent.

Uses

Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate is an organic synthesis reagent, mainly used in organic synthesis and chemical production.

Synthesis

KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18- crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min, ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and the reaction mixture was allowed to stir for 4 hr at room temperature. Following the standard workup procedure, the crude product was then purified by flash column chromatography (3:1 to 2:1 hexanes:EtOAc, Rf = 0.33 in 1:1 hexanes:EtOAc) yielding Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup.