2-Fluoro-5-iodonitrobenzene
- Product Name
- 2-Fluoro-5-iodonitrobenzene
- CAS No.
- 364-75-0
- Chemical Name
- 2-Fluoro-5-iodonitrobenzene
- Synonyms
- 4-Iodo-2-nitrofluorobenzene;2-Fluoro-5-iodonitrobenzene;3-nitro-4-fluoroiodobenzene;1-fluoro-4-iodo-2-nitrobenzene;2-Fluoro-5-iodonitrobenzene97%;2-Fluoro-5-iodonitrobenzene 97%;Benzene, 1-fluoro-4-iodo-2-nitro-
- CBNumber
- CB11114916
- Molecular Formula
- C6H3FINO2
- Formula Weight
- 267
- MOL File
- 364-75-0.mol
2-Fluoro-5-iodonitrobenzene Property
- Melting point:
- 34-36°
- Boiling point:
- 289.4±20.0 °C(Predicted)
- Density
- 2.093±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- liquid
- color
- Brown
- InChI
- InChI=1S/C6H3FINO2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H
- InChIKey
- KUJTZQXHTBKAMO-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(I)C=C1[N+]([O-])=O
Safety
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- I715708
- Product name
- 4-Iodo-2-nitrofluorobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I715708
- Product name
- 4-Iodo-2-nitrofluorobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- AK-34856
- Product name
- 1-Fluoro-4-iodo-2-nitrobenzene
- Purity
- 96%
- Packaging
- 250mg
- Price
- $6
- Updated
- 2021/12/16
- Product number
- AK-34856
- Product name
- 1-Fluoro-4-iodo-2-nitrobenzene
- Purity
- 96%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- PC50206
- Product name
- 2-Fluoro-5-iodonitrobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
2-Fluoro-5-iodonitrobenzene Chemical Properties,Usage,Production
Synthesis
1493-27-2
364-75-0
The general procedure for the synthesis of 2-fluoro-5-iodonitrobenzene from 1-fluoro-2-nitrobenzene is as follows: Intermediate Example 3. Synthesis of 1-fluoro-4-iodo-2-nitrobenzene To a solution of trifluoromethanesulfonic acid (15.6 ml, 177.15 mmol, 5 eq.) of 1-fluoro-2-nitrobenzene (5 g, 35.43 mmol) was added N-iodosuccinimide (9.57 g, 42.5 mmol, 1.2 eq.) in one batch at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction was quenched by addition of water and extracted with diethyl ether (3 x 150 ml). The organic layers were combined and washed sequentially with water, aqueous sodium thiosulfate and brine and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography (60-120 mesh silica gel, 5% ethyl acetate in hexane solution as eluent) to afford the target compound 1-fluoro-4-iodo-2-nitrobenzene in 66% yield (6.2 g). 1H NMR (300 MHz, DMSO-d6): δ 8.42 (dd, 1H), 8.18-8.13 (m, 1H), 7.46-7.39 (m, 1H).
References
[1] Journal of the American Chemical Society, 2004, vol. 126, # 48, p. 15770 - 15776
[2] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 30
[3] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0132
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1973, p. 595 - 599
2-Fluoro-5-iodonitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-5-iodonitrobenzene manufacturers
- Product
- 2-Fluoro-5-iodonitrobenzene 364-75-0
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-29
- Product
- 4-Iodo-2-nitrofluorobenzene 364-75-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 2-Fluoro-5-iodonitrobenzene 364-75-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11