Zatebradine
- Product Name
- Zatebradine
- CAS No.
- 85175-67-3
- Chemical Name
- Zatebradine
- Synonyms
- Zatebradine;UL-FS-49 free base;UL-FS-49CL free base;Zatebradine (UL-FS-49;3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
- CBNumber
- CB11117164
- Molecular Formula
- C26H36N2O5
- Formula Weight
- 456.58
- MOL File
- 85175-67-3.mol
Zatebradine Property
- Boiling point:
- 612.5±55.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 50 mg/mL (109.51 mM)
- pka
- 8.99±0.50(Predicted)
- form
- Oil
- color
- Light brown to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-3620
- Product name
- Zatebradine
- Purity
- 99.0%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-3620
- Product name
- Zatebradine
- Purity
- 99.0%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- BRS0000235
- Product name
- ZATEBRADINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.93
- Updated
- 2021/12/16
- Product number
- CS-3620
- Product name
- Zatebradine
- Purity
- 99.0%
- Packaging
- 50mg
- Price
- $588
- Updated
- 2021/12/16
- Product number
- DC9461
- Product name
- Zatebradine
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1000
- Updated
- 2021/12/16
Zatebradine Chemical Properties,Usage,Production
Originator
ZATEBRADINE HYDROCHLORIDE,Boenhringer Ingelheim
Definition
ChEBI: 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one is a benzazepine.
Manufacturing Process
A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-
(N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial
acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar.
After the catalyst had been filtered off, the solvent was evaporated in vacuum,
and the residue was taken up in methylene chloride. After the solution had
been extracted with an aqueous sodium bicarbonate solution and washed with
water, it was dried over magnesium sulfate, evaporated and purified over
silica gel with methylene chloride and then with increasing amounts of
methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-
benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of
theory. Melting point: 110°C (dec.).
1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of
3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-
benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10
mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while
maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring
was continued for 48 h at room temperature. After evaporating the solution in
vacuum, the residue was taken up in dilute hydrochloric acid and extracted
twice with ether. Subsequently, the aqueous phase was made alkaline and
extracted three times with methylene chloride, and the organic phase was
evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5-
tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-
dimethoxyphenyl}ethyl)amino]propane was obtained.
Therapeutic Function
Bradycardic
Zatebradine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Zatebradine manufacturers
- Product
- Zatebradine 85175-67-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Zatebradine 85175-67-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09