Zatebradine

Product Name: Zatebradine
CAS No.: 85175-67-3
Chemical Name: Zatebradine
Synonyms: Zatebradine;UL-FS-49 free base;UL-FS-49CL free base;Zatebradine (UL-FS-49;3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
CBNumber: CB11117164
Molecular Formula: C26H36N2O5
Formula Weight: 456.58
MOL File: 85175-67-3.mol

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Zatebradine Property

Boiling point:: 612.5±55.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : ≥ 50 mg/mL (109.51 mM)
pka: 8.99±0.50(Predicted)
form: Oil
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 10mg
Price: $135
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000235
Product name: ZATEBRADINE
Purity: 95.00%
Packaging: 5MG
Price: $501.93
Updated: 2021/12/16

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 50mg
Price: $588
Updated: 2021/12/16

DC Chemicals

Product number: DC9461
Product name: Zatebradine
Purity: >98%
Packaging: 250mg
Price: $1000
Updated: 2021/12/16

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Zatebradine Chemical Properties,Usage,Production

Originator

ZATEBRADINE HYDROCHLORIDE,Boenhringer Ingelheim

Definition

ChEBI: 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one is a benzazepine.

Manufacturing Process

A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3- (N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar. After the catalyst had been filtered off, the solvent was evaporated in vacuum, and the residue was taken up in methylene chloride. After the solution had been extracted with an aqueous sodium bicarbonate solution and washed with water, it was dried over magnesium sulfate, evaporated and purified over silica gel with methylene chloride and then with increasing amounts of methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of theory. Melting point: 110°C (dec.).
1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of 3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10 mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring was continued for 48 h at room temperature. After evaporating the solution in vacuum, the residue was taken up in dilute hydrochloric acid and extracted twice with ether. Subsequently, the aqueous phase was made alkaline and extracted three times with methylene chloride, and the organic phase was evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5- tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4- dimethoxyphenyl}ethyl)amino]propane was obtained.

Therapeutic Function

Bradycardic

Zatebradine Preparation Products And Raw materials

Raw materials

Preparation Products

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Zatebradine Suppliers

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View Lastest Price from Zatebradine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Zatebradine 85175-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Zatebradine 85175-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

85175-67-3, ZatebradineRelated Search:

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Cetirizine Ivabradine Nizatidine (S)-(+)-7,8-DIMETHOXY-3-[[1-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-PIPERIDINYL]METHYL]-1,3,4,5-TETRAHYDRO-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Ivabradine hydrochloride Zatebradine Cilobradine

Zatebradine

UL-FS-49 free base

UL-FS-49CL free base

2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-

3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one

Zatebradine (UL-FS-49

85175-67-3

C26H36N2O5