Zatebradine

Product Name: Zatebradine
CAS No.: 85175-67-3
Chemical Name: Zatebradine
Synonyms: Zatebradine;UL-FS-49 free base;UL-FS-49CL free base;Zatebradine (UL-FS-49;3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
CBNumber: CB11117164
Molecular Formula: C26H36N2O5
Formula Weight: 456.58
MOL File: 85175-67-3.mol

More

Less

Zatebradine Property

Boiling point:: 612.5±55.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : ≥ 50 mg/mL (109.51 mM)
pka: 8.99±0.50(Predicted)
form: Oil
color: Light brown to brown

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 5mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 10mg
Price: $135
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000235
Product name: ZATEBRADINE
Purity: 95.00%
Packaging: 5MG
Price: $501.93
Updated: 2021/12/16

ChemScene

Product number: CS-3620
Product name: Zatebradine
Purity: 99.0%
Packaging: 50mg
Price: $588
Updated: 2021/12/16

CSNpharm

Product number: CSN12233
Product name: Zatebradine
Packaging: 1mg
Price: $45
Updated: 2021/12/16

More

Less

Zatebradine Chemical Properties,Usage,Production

Originator

ZATEBRADINE HYDROCHLORIDE,Boenhringer Ingelheim

Definition

ChEBI: 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one is a benzazepine.

Manufacturing Process

A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3- (N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar. After the catalyst had been filtered off, the solvent was evaporated in vacuum, and the residue was taken up in methylene chloride. After the solution had been extracted with an aqueous sodium bicarbonate solution and washed with water, it was dried over magnesium sulfate, evaporated and purified over silica gel with methylene chloride and then with increasing amounts of methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of theory. Melting point: 110°C (dec.).
1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of 3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3- benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10 mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring was continued for 48 h at room temperature. After evaporating the solution in vacuum, the residue was taken up in dilute hydrochloric acid and extracted twice with ether. Subsequently, the aqueous phase was made alkaline and extracted three times with methylene chloride, and the organic phase was evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5- tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4- dimethoxyphenyl}ethyl)amino]propane was obtained.

Therapeutic Function

Bradycardic

Zatebradine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Zatebradine Suppliers

China 26 United Kingdom 1 United States 8 Global 35

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4601
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Baoji Guokang Bio-Technology Co., Ltd.

Tel: 0917-3909592 13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9314
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

Wuhan Boot Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6829
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6105
Advantage: 58

Shanghai Yuqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 847627550@qq.com
Country: CHINA
ProdList: 6087
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

More

Less

View Lastest Price from Zatebradine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Zatebradine 85175-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Zatebradine 85175-67-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

85175-67-3, ZatebradineRelated Search:

3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Cetirizine Ivabradine Nizatidine (S)-(+)-7,8-DIMETHOXY-3-[[1-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-PIPERIDINYL]METHYL]-1,3,4,5-TETRAHYDRO-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE Ivabradine hydrochloride Zatebradine Cilobradine

Zatebradine

UL-FS-49 free base

UL-FS-49CL free base

2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-

3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one

Zatebradine (UL-FS-49

85175-67-3

C26H36N2O5