Ivabradine hydrochloride
- Product Name
- Ivabradine hydrochloride
- CAS No.
- 148849-67-6
- Chemical Name
- Ivabradine hydrochloride
- Synonyms
- Ivabradine HCl;Procoralan;Ivabradine hydrochlorid;CS-774;S-16257;Corlentor;S 16257-2;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochloride
- CBNumber
- CB81006694
- Molecular Formula
- C27H37ClN2O5
- Formula Weight
- 505.05
- MOL File
- 148849-67-6.mol
Ivabradine hydrochloride Property
- Melting point:
- 193-196?C
- alpha
- 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
- storage temp.
- 2-8°C
- solubility
- H2O: ≥5mg/mL (warmed)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D +5 to +9°, c = 1 in DMSO
- Merck
- 14,5247
- InChI
- InChI=1/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/s3
- InChIKey
- HLUKNZUABFFNQS-ZMBIFBSDSA-N
- SMILES
- C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
- CAS DataBase Reference
- 148849-67-6(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- SML0281
- Product name
- Ivabradine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $93.4
- Updated
- 2024/03/01
- Product number
- SML0281
- Product name
- Ivabradine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- I0847
- Product name
- Ivabradine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $771
- Updated
- 2024/03/01
- Product number
- I0847
- Product name
- Ivabradine Hydrochloride
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 200mg
- Price
- $229
- Updated
- 2024/03/01
- Product number
- 15868
- Product name
- Ivabradine (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $73
- Updated
- 2024/03/01
Ivabradine hydrochloride Chemical Properties,Usage,Production
Description
In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .
Chemical Properties
White to Off-White Solid
Originator
Servier (France)
Uses
Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).
Uses
Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent
Uses
angina therapeutic
Uses
Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal
Definition
ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
brand name
Procoralan
Biochem/physiol Actions
Ivabradine is used to treat chronic heart failure.
Clinical Use
Symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm Treatment of mild to severe chronic heart failure
storage
Store at -20°C
Ivabradine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ivabradine hydrochloride manufacturers
- Product
- Ivabradine hydrochloride 148849-67-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 10 tons
- Release date
- 2024-03-18
- Product
- Ivabradine hydrochloride 148849-67-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-12-19
- Product
- Ivabradine hydrochloride 148849-67-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-20