(R)-(+)-2-BENZYLOXYPROPIONIC ACID
- Product Name
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID
- CAS No.
- 100836-85-9
- Chemical Name
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID
- Synonyms
- O-BENZYL-D-LACTIC ACID;(R)-(+)-O-Benzyllactic acid;(R)-2-(Benzyloxy)propanoic acid;(2R)-2-(Benzyloxy)propionic acid;(2R)-2-(benzyloxy)propanoic acid;(R)-(+)-2-BENZYLOXYPROPIONIC ACID;(R)-2-(Benzyloxy)propanoic acid ee;(2R)-2-phenylmethoxypropanoic acid;Propanoic acid, 2-(phenylMethoxy)-, (2R)-;(R)-(+)-2-(Benzyloxy)propionic acid[>=97.0% (HPLC)]
- CBNumber
- CB1111778
- Molecular Formula
- C10H12O3
- Formula Weight
- 180.2
- MOL File
- 100836-85-9.mol
(R)-(+)-2-BENZYLOXYPROPIONIC ACID Property
- Melting point:
- 52-55 °C
- Boiling point:
- 328.2±17.0 °C(Predicted)
- Density
- 1.150
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.57±0.10(Predicted)
- Appearance
- Off-white to yellow <43°C Solid,>43°C Liquid
- Water Solubility
- Insoluble in water.
- BRN
- 4675524
- InChI
- InChI=1S/C10H12O3/c1-8(10(11)12)13-7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,11,12)/t8-/m1/s1
- InChIKey
- XWAVPOFYNPXXEL-MRVPVSSYSA-N
- SMILES
- C(O)(=O)[C@H](OCC1=CC=CC=C1)C
- CAS DataBase Reference
- 100836-85-9
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B289173
- Product name
- (R)-(+)-2-BenzyloxypropionicAcid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B289173
- Product name
- (R)-(+)-2-BenzyloxypropionicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B289173
- Product name
- (R)-(+)-2-BenzyloxypropionicAcid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-M3394
- Product name
- (R)-(+)-2-Benzyloxypropionicacid
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- CS-M3394
- Product name
- (R)-(+)-2-Benzyloxypropionicacid
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $133
- Updated
- 2021/12/16
(R)-(+)-2-BENZYLOXYPROPIONIC ACID Chemical Properties,Usage,Production
Uses
(R)-(+)-2-Benzyloxypropionic acid is used as a pharmaceutical intermediate.
Synthesis
115458-99-6
100836-85-9
The general procedure for the synthesis of (R)-2-(benzyloxy)propionic acid from methyl (R)-2-(benzyloxy)propionate was as follows: potassium hydroxide (KOH, 9.2 g, 163.96 mmol, 3.00 eq.) was added to methyl (2R)-2-(benzyloxy)propionate (11 g, 56.63 mmol, 1.00 eq.) in a methanol/water (90 mL/10 mL) solution. The reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the reaction mixture was concentrated and subsequently diluted with water. The resulting aqueous solution was washed with ethyl acetate and the pH of the aqueous layer was adjusted with aqueous hydrochloric acid to 5. The acidified aqueous layer was extracted with ethyl acetate, the organic layers were combined and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum to give 9.6 g (94% yield) of (2R)-2-(benzyloxy)propionic acid as a colorless oil.LC-MS detection showed [M + H]+ = 179.
References
[1] Patent: WO2015/138934, 2015, A1. Location in patent: Paragraph 00174
[2] Tetrahedron Letters, 1998, vol. 39, # 8, p. 779 - 782
[3] Chemistry - A European Journal, 2015, vol. 21, # 26, p. 9370 - 9379
[4] Angewandte Chemie - International Edition, 2015, vol. 54, # 16, p. 4919 - 4922
[5] Angew. Chem., 2015, vol. 127, # 16, p. 5001 - 5004,4
(R)-(+)-2-BENZYLOXYPROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-(+)-2-BENZYLOXYPROPIONIC ACID Suppliers
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1077
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 0411-62313318 13942603642
- Fax
- 0411-87549748
- info@allychem.com
- Country
- China
- ProdList
- 1028
- Advantage
- 65
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
View Lastest Price from (R)-(+)-2-BENZYLOXYPROPIONIC ACID manufacturers
- Product
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID 100836-85-9
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID 100836-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11