Saccharin sodium dihydrate

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Saccharin sodium dihydrate

Product Name: Saccharin sodium dihydrate
CAS No.: 6155-57-3
Chemical Name: Saccharin sodium dihydrate
Synonyms: SODIUM SACCHARIN;O-BENZOIC SULFIMIDE SODIUM SALT;2-SULFOBENZOIC AND IMIDE SODIUM SALT DIHYDRATE;SOLUBLE SACCHARIN;Sweetener Sodium Saccharin;SACCHARIN SODIUM SALT DIHYDRATE;O-SULFOBENZIMIDE SODIUM SALT DIHYDRATE;O-BENZOIC SULFIMIDE SODIUM SALT DIHYDRATE;1,1-DIOXIDE-1,2-BENZISOTHIAZOLE-3(2H)-ONE SODIUM SALT, DIHYDRATE;2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE
CBNumber: CB1115998
Molecular Formula: C7H8NNaO4S
Formula Weight: 225.19
MOL File: 6155-57-3.mol

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Saccharin sodium dihydrate Property

Melting point:: > 300℃
Flash point:: >200°C
storage temp.: 2-8°C
solubility: 1000g/l
form: powder to crystaline
color: White to Almost white
PH: 6.0-7.5 (100g/l, H2O, 20℃)
Water Solubility: Soluble in water. Slightly soluble in alcohol
Merck: 14,8311
InChI: InChI=1S/C7H5NO3S.Na.H2O.H/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;;/h1-4H,(H,8,9);;1H2;
InChIKey: BCWVKFPXENUOQA-UHFFFAOYSA-N
SMILES: O=S1(NC(=O)C2C=CC=CC1=2)=O.[NaH].O
CAS DataBase Reference: 6155-57-3(CAS DataBase Reference)

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Safety

Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 2
RTECS: DE4375000
TSCA: Yes
HS Code: 29350090
Toxicity: LD50 orally in Rabbit: 14200 mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.17042
Product name: Saccharin sodium dihydrate
Purity: EMPROVE? ESSENTIAL, Ph. Eur., USP
Packaging: 1KG
Price: $294
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.17042
Product name: Saccharin sodium dihydrate
Purity: EMPROVE? ESSENTIAL, Ph. Eur., USP
Packaging: 5KG
Price: $733
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14114
Product name: Saccharin sodium salt dihydrate
Purity: for synthesis
Packaging: 100G
Price: $36.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14114
Product name: Saccharin sodium salt dihydrate
Purity: for synthesis
Packaging: 1KG
Price: $151
Updated: 2024/03/01

TCI Chemical

Product number: B0131
Product name: o-Sulfobenzimide Sodium Salt Dihydrate
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $36
Updated: 2024/03/01

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Saccharin sodium dihydrate Chemical Properties,Usage,Production

Description

Saccharin sodium dihydrate is the sodium dihydrate form of saccharin, which belongs to the family of aromatic homomonocyclic compounds. It is an artificial sweetener that is hundreds times as sweet as sucrose. It is mainly used as a food additive to sweeten many products such as drinks, candies, cookies, and medicine. Saccharin is relatively safe for human beings without providing food energy and any nutritional value. It is also safe for diabetes patients to consume.

Chemical Properties

dihydrate granular

Chemical Properties

Saccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.

Uses

Sweetener (non-nutritive).

Uses

Saccharin Sodium Salt Dihydrate is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.

Production Methods

Saccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.

brand name

Sucaryl (Ross).

Pharmaceutical Applications

Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.

Safety

There has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg

storage

Saccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.

Incompatibilities

Saccharin sodium does not undergo Maillard browning.

Regulatory Status

Accepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

https://en.wikipedia.org/wiki/Saccharin
https://pubchem.ncbi.nlm.nih.gov/compound/saccharin#section=Top

Saccharin sodium dihydrate Preparation Products And Raw materials

Raw materials

PotassiuM iodide starch pa Methyl anthranilate Sodium hypochlorite Saccharin Ammonium hydroxide 2-Aminobiphenyl Water Dark green Sodium bisulfite solution Copper(II) sulfate Methyl 2-(chlorosulfonyl)benzoate

Preparation Products

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View Lastest Price from Saccharin sodium dihydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Saccharin Sodium Dihydrate 6155-57-3
Price: US $99.00-35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 ton
Release date: 2024-05-09

HebeiShuoshengImportandExportco.,Ltd

Product: Saccharin sodium dihydrate 6155-57-3
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-06

Hebei Longbang Technology Co., Ltd

Product: Saccharin sodium dihydrate 6155-57-3
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-27

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