ChemicalBook > CAS DataBase List > 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Uses

Product Name: 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CAS No.: 81237-69-6
Chemical Name: 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
Synonyms: 5-Bromo-1,2,3,4-tetrahydroisoquinolie;5-Bromo-1,2,3,4-tetrahydroisoquinoline;5-BroMo-1,2,3,4-tetrahdyroisoquinoline;5-bromanyl-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 5-bromo-1,2,3,4-tetrahydro-;5-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;5-Bromo-1,2,3,4-tetrahydroisoquinoline 97+%;5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CBNumber: CB1117048
Molecular Formula: C9H10BrN
Formula Weight: 212.09
MOL File: 81237-69-6.mol

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5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Property

Boiling point:: 294.3±40.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.99±0.20(Predicted)
form: solid
color: Pale yellow
InChI: InChI=1S/C9H10BrN/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-3,11H,4-6H2
InChIKey: IZCCDTQAIOPIGY-UHFFFAOYSA-N
SMILES: C1C2=C(C(Br)=CC=C2)CCN1

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Safety

Hazard Codes: Xn
Risk Statements: 22-51
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B688135
Product name: 5-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging: 1g
Price: $140
Updated: 2021/12/16

Ark Pharm

Product number: P000220704
Product name: 5-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 97+%
Packaging: 250mg
Price: $20
Updated: 2021/12/16

Apolloscientific

Product number: OR18818
Product name: 5-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 97+%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-9-24
Product name: 5-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 97.0%
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Ark Pharm

Product number: P000220704
Product name: 5-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 97+%
Packaging: 1g
Price: $46
Updated: 2021/12/16

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5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

5-Bromo-1,2,3,4-tetrahydroisoquinoline is used to prepare Vaniprevir (MK-7009), a macrocyclic hepatitis C Virus NS3/4a protease inhibitor.

Uses

5-Bromo-1,2,3,4-tetrahydro-isoquinoline, HCl

Synthesis

34784-04-8

81237-69-6

General procedure for the synthesis of 5-bromo-1,2,3,4-tetrahydroisoquinoline from 5-bromoisoquinoline: 5-bromoisoquinoline (25 g, 120.2 mmol) was dissolved in acetic acid (250 mL). Three equivalents of NaBH4 (13.6 g, 359.5 mmol) were added to the reaction system in batches and the reaction was carried out at room temperature and the progress of the reaction was monitored by LC-MS. Upon completion of the reaction, the pH of the reaction solution was adjusted with saturated aqueous NaHCO3 solution to about 8. Subsequently, the reaction mixture was extracted with ethyl acetate and the organic phases were combined and washed with saturated NaCl solution. The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography to afford 5-bromo-1,2,3,4-tetrahydroisoquinoline (10 g, yield: 40%).

References

[1] Journal of the American Chemical Society, 2012, vol. 134, # 42, p. 17592 - 17598,7
[2] Patent: CN107540659, 2018, A. Location in patent: Paragraph 0225-0226

5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers

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View Lastest Price from 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 81237-69-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-07

81237-69-6, 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDERelated Search:

5-Bromo-1H-benzimidazole 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 1'-Benzyl-5-bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one 5-Bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one hydrochloride 5-bromo-6-pyrrolidin-1-ylnicotinic acid ETHYL 5-BROMO-3-(2-CARBOXY-VINYL)-1H-INDOLE-2-CARBOXYLATE 5-BROMOTHIAZOLE-2-CARBOXYLIC ACID METHYL 6-AMINO-5-BROMOPICOLINATE 1,2,4-thiadiazol-5-amine 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 8-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline 5-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID 5-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER

5-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HCL

5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

5-BroMo-1,2,3,4-tetrahdyroisoquinoline

5-bromanyl-1,2,3,4-tetrahydroisoquinoline

5-Bromo-1,2,3,4-tetrahydroisoquinolie

5-Bromo-1,2,3,4-tetrahydroisoquinoline

5-Bromo-1,2,3,4-tetrahydroisoquinoline 97+%

Isoquinoline, 5-bromo-1,2,3,4-tetrahydro-

81237-69-6