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Sildenafil Chlorosulfonyl

Product Name
Sildenafil Chlorosulfonyl
CAS No.
139756-22-2
Chemical Name
Sildenafil Chlorosulfonyl
Synonyms
Sildenafil Impurity 7;Methisosildenafil-004;Sildenafil　intermediate;Sildenafil Chlorosulfone;Sildenafil chlorosulfonyl;Methisosildenafil Impurity 33;Sildenafil Chlorosulfone IMpurity;Sildenafil Chlorosulfonyl IMpurity;5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1-;4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro
CBNumber
CB11175931
Molecular Formula
C17H19ClN4O4S
Formula Weight
410.88
MOL File
139756-22-2.mol
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Sildenafil Chlorosulfonyl Property

Melting point:
180-182°C
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
9.87±0.20(Predicted)
color 
White to Pale Beige
Stability:
Moisture Sensitive
InChI
InChI=1S/C17H19ClN4O4S/c1-4-6-12-14-15(22(3)21-12)17(23)20-16(19-14)11-9-10(27(18,24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,19,20,23)
InChIKey
RVVOSOSBFSYZDM-UHFFFAOYSA-N
SMILES
C1(S(Cl)(=O)=O)=CC=C(OCC)C(C2NC(=O)C3N(C)N=C(CCC)C=3N=2)=C1
CAS DataBase Reference
139756-22-2
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

TRC
Product number
C380005
Product name
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
C380005
Product name
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Packaging
1g
Price
$90
Updated
2021/12/16
TRC
Product number
C380005
Product name
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Packaging
2.5g
Price
$195
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20392
Product name
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Packaging
25mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20392
Product name
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Packaging
50mg
Price
$100
Updated
2021/12/16
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Sildenafil Chlorosulfonyl Chemical Properties,Usage,Production

Description

Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil. It is also a potential impurity found in commercial preparations of sildenafil.

Chemical Properties

Off-White Solid

Uses

The compound Sildenafil Chlorosulfonyl Impurity (139756-22-2) is a derivative of Sildenafil. It is widely used in the treatment of pulmonary hypertension as it is capable of inhibiting cGMP and acts as a potent selective inhibitor of PDE5.

Sildenafil Chlorosulfonyl Preparation Products And Raw materials

Raw materials

Preparation Products

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Sildenafil Chlorosulfonyl Suppliers

Canada 1 China 134 India 10 United Kingdom 1 United States 13 Global 159
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View Lastest Price from Sildenafil Chlorosulfonyl manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride 139756-22-2
Price
US $100.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
2 tons
Release date
2023-09-04
Career Henan Chemical Co
Product
5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 139756-22-2
Price
US $3.00/KG
Min. Order
1ASSAYS
Purity
99%
Supply Ability
100kg
Release date
2019-09-03

139756-22-2, Sildenafil ChlorosulfonylRelated Search:

Tofacitinib citrate 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-(5-chloro-2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl- KF31327 5-CHLOROSULFONYL-2-ETHOXYBENZOIC ACID 2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]BENZOIC ACID 1-Piperazinesulfonicacid,4-methyl-(9CI) Lidocaine Impurity MONOETHYLGLYCINEXYLIDIDE Nor Lidocaine Hydrochloride N-(2,6-DIMETHYLPHENYL)-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE Methisosildenafil impure Acotiamide Impurity Terazosin EP Impurity O Methisosildenafil Impurity 7,8-Dihydro-14-hydroxy- normorphinone Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Donepezil Impurity 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester

  • 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1 H-pyrazolo-(4-3-d)-pyrimidine-5
  • 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride
  • 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • 5-(5-CHLOROSULFONYL-2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL-1
  • Sildenafil Chlorosulfonyl IMpurity
  • 4-Ethoxy-3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyriMidin-5-yl)benzene-1-sulfonyl chloride
  • Sildenafil Chlorosulfone IMpurity
  • 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-sulfo
  • 4-Ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride
  • Sildenafil　intermediate
  • 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)
  • 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-su
  • Sildenafil Impurity 7
  • Methisosildenafil-004
  • 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one
  • Sildenafil impurity 33/Sildenafil Chlorosulfonyl/Sildenafil Chlorosulfone Impurity/5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one
  • 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro
  • 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1-
  • 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1- METHYL-3-PROPYL-1 6-DIHYDRO-7H-PYRAZOL O-(4 3-D)PYRIMIDINE-7-ONE
  • Methisosildenafil Impurity 33
  • Benzenesulfonyl chloride, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-
  • Demethylpiperazinyl sildenafil sulfonyl chloride
  • 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride
  • 5-(5-CHLORO SULFONYL-2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO-[4,3,D]-PYRIMIDINE-7-ONE
  • 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-Chemicalbookpropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-di...
  • Sildenafil Chlorosulfone
  • Sildenafil Chlorosulfonyl (5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one)
  • Sildenafil chlorosulfonyl
  • 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo4,3-dpyrimidin-5-yl)benzene-1-sulfonyl chloride
  • 4-Ethoxy-3-(1-methy1-7-oxo~3-propy1-6,7-diliydro-lH-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-suIfonyl cliloride
  • Sildenafil Chlorosulfone Impurity / Sildenafil Chlorosulfone / Sildenafil Chlorosulfonyl Impurity
  • 139756-22-2
  • Bases & Related Reagents
  • Nucleotides
  • Sulfonyl Chlorides