Fudosteine

Product Name: Fudosteine
CAS No.: 13189-98-5
Chemical Name: Fudosteine
Synonyms: Fudostin;Fudostan;FUDESTEINE;FUDOSTEINE;fodosteine;Fu si temple;Fudosteine99%;D6-Fudosteine HCl;Fudosteine USP/EP/BP;Fulvestrant 9 sulfone D5
CBNumber: CB1128341
Molecular Formula: C6H13NO3S
Formula Weight: 179.24
MOL File: 13189-98-5.mol

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Fudosteine Property

Melting point:: 200-202°C (dec.)
Boiling point:: 354.5±42.0 °C(Predicted)
Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Water (Slightly)
form: Solid
pka: 2.09±0.10(Predicted)
color: White to Light Brown
InChI: InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
InChIKey: KINWYTAUPKOPCQ-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@H](CSCCCO)N
CAS DataBase Reference: 13189-98-5(CAS DataBase Reference)

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Safety

RTECS: HA2350000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16722
Product name: Fudosteine
Purity: ≥95%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16722
Product name: Fudosteine
Purity: ≥95%
Packaging: 25mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 16722
Product name: Fudosteine
Purity: ≥95%
Packaging: 50mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16722
Product name: Fudosteine
Purity: ≥95%
Packaging: 100mg
Price: $199
Updated: 2024/03/01

TRC

Product number: H952575
Product name: S-(3-Hydroxypropyl)-L-cysteine
Packaging: 500mg
Price: $580
Updated: 2021/12/16

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Fudosteine Chemical Properties,Usage,Production

Description

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.

Description

Fudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic acid in sputa, so exhibiting mucoregulatory properties. In another study with SO₂-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature increased by SO₂, partly due to scavenging of superoxide anion.

Chemical Properties

Off-White Powder

Originator

SS Pharmaceutical/Mitsubishi Pharma (Japan)

Uses

An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.

Uses

An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.

Uses

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment

Uses

A demonstrated antiinflammatory

Uses

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.

Definition

ChEBI: Fudosteine is an organic molecular entity.

brand name

Cleanal, Spelear (Mitsubishi Pharma)

Hazard

A reproductive hazard.

Synthesis

Fudosteine is synthesized by condensation of L-cysteine with 3-bromopropyl alcohol in aqueous NaOH, or by condensation of L-cysteine with allyl alcohol by means of aqueous potassium persulfate.

References

[1] KOICHI TAKAHASHI . Effects of SS320A, a New Cysteine Derivative, on the Change in the Number of Goblet Cells Induced by Isoproterenol in Rat Tracheal Epithelium[J]. Japanese journal of pharmacology, 1998, 77 1: Pages 71-78. DOI: 10.1254/jjp.77.71
[2] C K RHEE. Effect of fudosteine on mucin production.[J]. European Respiratory Journal, 2008: 1195-1202. DOI: 10.1183/09031936.00018508
[3] RAHMAN I. Pharmacological antioxidant strategies as therapeutic interventions for COPD[J]. Biochimica et biophysica acta. Molecular basis of disease, 2012, 1822 5: Pages 714-728. DOI: 10.1016/j.bbadis.2011.11.004

Fudosteine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fudosteine Suppliers

Canada 1 China 305 Europe 2 Germany 1 India 6 South Korea 1 United Kingdom 7 United States 29 Global 352

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View Lastest Price from Fudosteine manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Fudosteine 13189-98-5
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fudosteine 13189-98-5
Price: US $0.00/g
Min. Order: 10g
Purity: 99%~101%
Supply Ability: 10kg/month
Release date: 2021-07-28

Henan Bao Enluo International TradeCo.，LTD

Product: Fudosteine 13189-98-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-16

13189-98-5, FudosteineRelated Search:

Dilauryl thiodipropionate β-Alanine ALTRENOGEST Glycine 6-Aminocaproic acid N-Aminothiourea Propionic acid Dithiooxamide S-Carboxymethyl-L-cysteine Erdosteine L-ALANINE, 3-[(3-HYDROXYPROPYL)SULFINYL]- Fudosteine Impurity 5 Fudosteine Impurity 2 Tris(hydroxymethyl)aminomethane Fudosteine Impurity 1 Fudosteine Impurity 3 Fudosteine Impurity 2 Fudosteine Impurity 4

FUDESTEINE

Fudosteine (R)-2-Amino-3-(3-hydroxypropylthio)propionic acid

(2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanoic acid

(2R)-2-amino-3-(3-hydroxypropylthio)propionic acid

(2R)-2-azanyl-3-(3-hydroxypropylsulfanyl)propanoic acid

3-[(3-Hydroxypropyl)thio]alanine

(r)-2-amino-3-(3-hydroxypropylthio)propionic acid

S-(3-HYDROXYPROPYL)CYSTEINE

FUDOSTEINE

2-amino-3-(3-hydroxypropylthio)propanoic acid

3-((3-hydroxypropyl)thio)-alanin

s-(3-hydroxypropyl)-l-cystein

s-(3-hydroxypropyl)-l-cysteine

Fudosteine99%

FUDOSTEINE(SUBJECTTOPATENTFREE)

(R)-2-amino-3-((3-hydroxypropyl)thio)propanoic acid

L-Cysteine, S-(3-hydroxypropyl)-

Fudosteine,S-(3-Hydroxypropyl)cysteine,3-[(3-Hydroxypropyl)thio]alanine

Fudosteine USP/EP/BP

Fudosteine Impurities1413

fodosteine

Fudosteine D6Q: What is Fudosteine D6 Q: What is the CAS Number of Fudosteine D6 Q: What is the storage condition of Fudosteine D6 Q: What are the applications of Fudosteine D6

FudosteineQ: What is Fudosteine Q: What is the CAS Number of Fudosteine Q: What is the storage condition of Fudosteine Q: What are the applications of Fudosteine

Fu si temple

Fulvestrant 9 sulfone D5

Fudostin

Fudostan

D6-Fudosteine HCl

13189-98-5

C6H13O2S

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives

Other APIs

Sulfur & Selenium Compounds