3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- Product Name
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- CAS No.
- 152803-24-2
- Chemical Name
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- Synonyms
- 5-Hydroxynicotinonitrile;3-Cyano-5-hydroxypyridine;5-isocyano-pyridin-3-ol;3-Hydroxy-5-Cyanopyridine;5-Cyano-3-Hydroxypyridine;3-Cyano-5-hydroxypyridine,97%;5-Hydroxynicotinonitrile 97%;3-Pyridinecarbonitrile,5-hydroxy;3-Pyridinecarbonitrile,5-hydroxy-(9cl);3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- CBNumber
- CB11287472
- Molecular Formula
- C6H4N2O
- Formula Weight
- 120.11
- MOL File
- 152803-24-2.mol
3-Pyridinecarbonitrile,5-hydroxy-(9CI) Property
- Melting point:
- 213-217℃
- Boiling point:
- 394.7±27.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.96±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H4N2O/c7-2-5-1-6(9)4-8-3-5/h1,3-4,9H
- InChIKey
- KAXIYYPIORYZLB-UHFFFAOYSA-N
- SMILES
- C1=NC=C(O)C=C1C#N
- CAS DataBase Reference
- 152803-24-2
Safety
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C988078
- Product name
- 3-Cyano-5-hydroxypyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C988078
- Product name
- 3-Cyano-5-hydroxypyridine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC41935
- Product name
- 3-Cyano-5-hydroxypyridine
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- W3332
- Product name
- 3-Cyano-5-hydroxypyridine
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 072735
- Product name
- 3-Cyano-5-hydroxypyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $221
- Updated
- 2021/12/16
3-Pyridinecarbonitrile,5-hydroxy-(9CI) Chemical Properties,Usage,Production
Uses
3-Cyano-5-hydroxypyridine is active pharmaceutical ingredients.
Synthesis
298204-74-7
152803-24-2
General procedure for the synthesis of 3-cyano-5-hydroxypyridine from 5-methoxynicotinonitrile: 1 g of 5-methoxynicotinonitrile (7.46 mmol) was mixed with 8.62 g of pyridine hydrochloride, and the reaction was heated at 200 °C for 2 hours. After completion of the reaction, the crude product was diluted with water and extracted several times with ether. The aqueous phase was alkalized by addition of sodium bicarbonate and extracted again with ether. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 850 mg of 5-hydroxynicotinonitrile as a beige solid in 95% yield. The product was analyzed by LC-MS: m/z 120.94 (M+H+). 1H NMR (400 MHz, DMSO-d6): δ 10.79 (s, 1H, OH), 8.46 (s, 1H, Harom.), 8.42 (s, 1H, Harom.), 7.60 (s, 1H, Harom.).
References
[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0394; 0395; 0396
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0238
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 73
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 72
3-Pyridinecarbonitrile,5-hydroxy-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinecarbonitrile,5-hydroxy-(9CI) manufacturers
- Product
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI) 152803-24-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 5-HYDROXYNICOTINONITRILE 152803-24-2
- Price
- US $60.00/KG
- Min. Order
- 1000KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2022-01-05
- Product
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI) 152803-24-2
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07