ChemicalBook > CAS DataBase List > 3-Pyridinecarbonitrile,5-hydroxy-(9CI)

3-Pyridinecarbonitrile,5-hydroxy-(9CI)

Product Name
3-Pyridinecarbonitrile,5-hydroxy-(9CI)
CAS No.
152803-24-2
Chemical Name
3-Pyridinecarbonitrile,5-hydroxy-(9CI)
Synonyms
5-Hydroxynicotinonitrile;3-Cyano-5-hydroxypyridine;5-isocyano-pyridin-3-ol;3-Hydroxy-5-Cyanopyridine;5-Cyano-3-Hydroxypyridine;3-Cyano-5-hydroxypyridine,97%;5-Hydroxynicotinonitrile 97%;3-Pyridinecarbonitrile,5-hydroxy;3-Pyridinecarbonitrile,5-hydroxy-(9cl);3-Pyridinecarbonitrile,5-hydroxy-(9CI)
CBNumber
CB11287472
Molecular Formula
C6H4N2O
Formula Weight
120.11
MOL File
152803-24-2.mol
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3-Pyridinecarbonitrile,5-hydroxy-(9CI) Property

Melting point:
213-217℃
Boiling point:
394.7±27.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
7.96±0.10(Predicted)
Appearance
Off-white to light yellow Solid
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C6H4N2O/c7-2-5-1-6(9)4-8-3-5/h1,3-4,9H
InChIKey
KAXIYYPIORYZLB-UHFFFAOYSA-N
SMILES
C1=NC=C(O)C=C1C#N
CAS DataBase Reference
152803-24-2
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Safety

RIDADR 
3439
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C988078
Product name
3-Cyano-5-hydroxypyridine
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
C988078
Product name
3-Cyano-5-hydroxypyridine
Packaging
250mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC41935
Product name
3-Cyano-5-hydroxypyridine
Packaging
1g
Price
$180
Updated
2021/12/16
AK Scientific
Product number
W3332
Product name
3-Cyano-5-hydroxypyridine
Packaging
250mg
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
072735
Product name
3-Cyano-5-hydroxypyridine
Purity
95+%
Packaging
1g
Price
$221
Updated
2021/12/16
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3-Pyridinecarbonitrile,5-hydroxy-(9CI) Chemical Properties,Usage,Production

Uses

3-Cyano-5-hydroxypyridine is active pharmaceutical ingredients.

Synthesis

298204-74-7

152803-24-2

General procedure for the synthesis of 3-cyano-5-hydroxypyridine from 5-methoxynicotinonitrile: 1 g of 5-methoxynicotinonitrile (7.46 mmol) was mixed with 8.62 g of pyridine hydrochloride, and the reaction was heated at 200 °C for 2 hours. After completion of the reaction, the crude product was diluted with water and extracted several times with ether. The aqueous phase was alkalized by addition of sodium bicarbonate and extracted again with ether. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 850 mg of 5-hydroxynicotinonitrile as a beige solid in 95% yield. The product was analyzed by LC-MS: m/z 120.94 (M+H+). 1H NMR (400 MHz, DMSO-d6): δ 10.79 (s, 1H, OH), 8.46 (s, 1H, Harom.), 8.42 (s, 1H, Harom.), 7.60 (s, 1H, Harom.).

References

[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0394; 0395; 0396
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0238
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 73
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 72

3-Pyridinecarbonitrile,5-hydroxy-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Pyridinecarbonitrile,5-hydroxy-(9CI) manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Pyridinecarbonitrile,5-hydroxy-(9CI) 152803-24-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Honest Joy Holdings Limited
Product
5-HYDROXYNICOTINONITRILE 152803-24-2
Price
US $60.00/KG
Min. Order
1000KG
Purity
99%
Supply Ability
20 tons
Release date
2022-01-05
Career Henan Chemical Co
Product
3-Pyridinecarbonitrile,5-hydroxy-(9CI) 152803-24-2
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-07

152803-24-2, 3-Pyridinecarbonitrile,5-hydroxy-(9CI)Related Search:

3-Cyano-7-chloroindole 5,6-Dibromonicotinonitrile 2-Pyridinecarbonitrile,4-hydroxy-(9CI) 4-Methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-carbonitrile 3-Pyridinecarbonitrile,5-methoxy-(9CI) 3-Pyridinecarbonitrile,5-hydroxy-(9CI) 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-(4-piperidinyl)-2H-isoindol-2-yl]- Lamivudine 7-Benzothiazolol,2-amino-(9CI) 5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one 4-(Aminomethyl)benzoic acid N1,N1'-((trans-Cyclohexane-1,4-diyl)bis(methylene))bis(ethane-1,2-diamine) 5-METHYLINDOLE-3-ACETIC ACID 3-Fluoro-2-nitropyridine 4-Amino-3-fluoropyridine 3-FLUORO-2-METHYLPYRIDINE 3-CHLORO-2-METHYLPYRIDINE

  • 5-isocyano-pyridin-3-ol
  • 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
  • 5-Hydroxynicotinonitrile
  • 5-Cyano-3-Hydroxypyridine
  • 3-Cyano-5-hydroxypyridine
  • 3-Pyridinecarbonitrile,5-hydroxy
  • 5-Hydroxynicotinonitrile 97%
  • 3-Pyridinecarbonitrile,5-hydroxy-(9cl)
  • 3-Cyano-5-hydroxypyridine,97%
  • 3-Pyridinecarbonitrile,5-hydroxy-(9CI) ISO 9001：2015 REACH
  • 3-Hydroxy-5-Cyanopyridine
  • 152803-24-2 3-Pyridinecarbonitrile,5-hydroxy-(9CI) C6H4N2O
  • 3-Hydroxy-5-Cyanopyridine (3-Cyano-5-Hydroxypyridine)
  • 152803-24-2
  • PYRIDINE
  • Heterocyclic Compounds
  • Heterocycle-Pyridine series