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nimbolide

Product Name
nimbolide
CAS No.
25990-37-8
Chemical Name
nimbolide
Synonyms
nimbolide;NSC 309909;Nimbolide (25 mg);Nimbolide, 10 mM in DMSO;Nimbolide, CyclinA and ERK1/2 inhibitor;(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone;methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate;2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
CBNumber
CB11328652
Molecular Formula
C27H30O7
Formula Weight
466.52
MOL File
25990-37-8.mol
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nimbolide Property

Melting point:
>223°C (dec.)
Boiling point:
608.6±55.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform, Ethyl Acetate
form 
powder
color 
Light Beige to Yellow
InChIKey
KMTFKEPRKBPCJW-UHFFFAOYSA-N
SMILES
C12C3(C)C=CC(=O)C1(C)C(CC(=O)OC)C1(C)C4C(C(C=C4C)C4=COC=C4)OC1C2OC3=O
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Safety

RTECS 
GY2370000
Toxicity
hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00586
Product name
Nimbolide
Purity
from Azadirachta indica, ≥98%
Packaging
5mg
Price
$354.9
Updated
2025/07/31
Cayman Chemical
Product number
19230
Product name
Nimbolide
Purity
≥97%
Packaging
5mg
Price
$251
Updated
2024/03/01
Cayman Chemical
Product number
19230
Product name
Nimbolide
Purity
≥97%
Packaging
25mg
Price
$1058
Updated
2024/03/01
Tocris
Product number
7289
Product name
Nimbolide
Purity
≥97%(HPLC)
Packaging
25
Price
$1029
Updated
2021/12/16
Usbiological
Product number
N2567-38
Product name
Nimbolide
Packaging
5mg
Price
$440
Updated
2021/12/16
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nimbolide Chemical Properties,Usage,Production

Chemical Properties

Light Beige Solid

Uses

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong growth inhibition.

Biological Activity

Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer.

in vivo

Nimbolide (10 mg/kg, i.v., daily, 7 days) inhibits glioblastoma multiforme tumor growth in U87EGFRvⅢ xenografted mouse model[2].
Nimbolide (5 mg/kg, 20 mg/kg; i.p.; daily, 10 days), inhibits tumor growth in HCT-116-derived xenograft mouse, reduces the expression of proteins involved in invasion, metastasis, and angiogenesis (MMP-9, CXCR4, ICAM-1, and VEGF)[5].

Animal Model:HCT-116-derived xenograft mouse[5]
Dosage:5 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection (i.p.), daily, 10 days
Result:Suppressed tumor growth in nude mice at a dose as low as 5 mg/kg.
Reduced tumor growth by almost 90% on day 10 at a dose as low as 20 mg/kg.
Didn’t affect the body weight of mice.

IC 50

NF-κB; CDK4; CDK6

storage

Store at -20°C

nimbolide Preparation Products And Raw materials

Raw materials

Preparation Products

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nimbolide Suppliers

Canada 2 CHINA 102 India 3 United Kingdom 1 United States 7 Global 115
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

25990-37-8, nimbolideRelated Search:

5,7-Dihydrox -4'-methoxyisoflavone Indacaterol INDACONITINE 4-Hexanolide Toosendanin (CIS)-8-METHYLNON-6-ENOIC ACID AZELAIC ACID MONOMETHYL ESTER nimbolide 4-ACETYL-4-METHYLHEPTANEDIOIC ACID 4-HYDROXYMETHYL-4-METHYL-CYCLOHEX-2-ENONE

  • nimbolide
  • (17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone
  • NSC 309909
  • 2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
  • methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate
  • Nimbolide (25 mg)
  • Nimbolide, CyclinA and ERK1/2 inhibitor
  • Nimbolide, 10 mM in DMSO
  • 25990-37-8
  • C27H30O72
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals