5-Methyl-2'-deoxycytidine

Product Name: 5-Methyl-2'-deoxycytidine
CAS No.: 838-07-3
Chemical Name: 5-Methyl-2'-deoxycytidine
Synonyms: 5-mdC;5-Me-dC;5MedCyd;5-Me-2'-dC;5-METHYL-DC;5-Methyl-2'-deoxycyt;Deoxy methylcytidine;5-Me-2'-deoxycytidine;5-methyldeoxycytidine;2'-Deoxy-5-Mecytidine
CBNumber: CB1132913
Molecular Formula: C10H15N3O4
Formula Weight: 241.24
MOL File: 838-07-3.mol

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5-Methyl-2'-deoxycytidine Property

Melting point:: 217-219 °C(lit.)
Boiling point:: 492.8±55.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
refractive index: 44 ° (C=1.4, H2O)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
form: Powder
pka: pK1:4.33 (25°C)
color: White to Off-white
Water Solubility: Soluble in water.
Stability:: Hygroscopic
CAS DataBase Reference: 838-07-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
RTECS: HA3860000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3610
Product name: 2'-Deoxy-5-methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: D3610
Product name: 2'-Deoxy-5-methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 500mg
Price: $201
Updated: 2024/03/01

Alfa Aesar

Product number: J65209
Product name: 5-Methyl-2'-deoxycytidine, 99%
Packaging: 1g
Price: $89.4
Updated: 2024/03/01

Cayman Chemical

Product number: 16166
Product name: 5-Methyl-2'-deoxycytidine
Purity: ≥98%
Packaging: 1g
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 16166
Product name: 5-Methyl-2'-deoxycytidine
Purity: ≥98%
Packaging: 5g
Price: $341
Updated: 2024/03/01

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5-Methyl-2'-deoxycytidine Chemical Properties,Usage,Production

Description

5-Methyl-2'-deoxycytidine is a nucleoside analogue that inhibits the synthesis of DNA. 5-Methyl-2'-deoxycytidine prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

Chemical Properties

White Solid

Uses

5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.

Uses

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation.

Uses

A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).

General Description

Giel-Pietraszuk et al. developed a new method for quantification of 5-methyl-2'-deoxycytidine (m5C) in the DNA. The technique is based on the conversion of m5C into fluorescent 3, N4-etheno-5-methyl-2'-deoxycytidine (εm5C) and its identification by reversed-phase high-performance liquid chromatography (RP-HPLC)[1].The measurement of 5-meC and 5-medC in urine may help assess changes in DNA methylation status in the whole body and investigate the DNA demethylation mechanism in vivo. 5-MedC was first detected in urine using an inhibition ELISA method;12 however, because ELISA may suffer from poor selectivity and sensitivity, later urinary measurements of 5-medC were developed mainly based on the chromatographic techniques[2].

Definition

ChEBI: 5-methyl-2'-deoxycytidine is a 2'-deoxycytidine.

References

[1] Ma?gorzata Giel-Pietraszuk. “Quantification of 5-methyl-2’-deoxycytidine in the DNA.” Acta biochimica Polonica 62 2 (2015): 281–6.
[2] Chiung-Wen Hu. “Direct Analysis of 5-Methylcytosine and 5-Methyl-2′-deoxycytidine in Human Urine by Isotope Dilution LC-MS/MS: Correlations with N-Methylated Purines and Oxidized DNA Lesions.” Chemical Research in Toxicology 25 2 (2012): 462–470.

5-Methyl-2'-deoxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methyl-2'-deoxycytidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Methyl-2'-deoxycytidine 838-07-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Methyl-2"-deoxycytidine 838-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Methyl-2"-deoxycytidine 838-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

838-07-3, 5-Methyl-2'-deoxycytidineRelated Search:

5-METHYLCYTOSINE Thymine Methylparaben Cytarabine Cytidine Methanol Kresoxim-methyl 5-Azacytidine Basic Violet 1 Cytidine-5'-triphosphate disodium salt dihydrate Cytosine Floxuridine METSULFURON METHYL 5-Fluorocytidine Tribenuron methyl Zalcitabine Fluorocytosine Methyl salicylate

5-METHYL-DC

5-METHYL-2'-DEXOYCYTIDINE

5-METHYL-2'-DEOXYCYTIDINE

4-AMINO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDIN-2-ONE

2'-DEOXY-5-METHYLCYTIDINE

2’-deoxy-5-methyl-cytidin

5-Me-2'-deoxycytidine

2'-Deoxy-5-methylcytidine, ≥99%(HPLC)

2'-Deoxy-5-Me-Cytidine

5-methyldeoxycytidine

2'-Deoxy-5-methyl-D-cytidine

4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE)

1-(2-Deoxy-beta-D-ribofuranosyl)-5-methylcytosine

5-Methyl-2'-deoxycyt

5-Me-2'-dC

Cytidine, 2'-deoxy-5-methyl-

(2R,3R,4S,5R)-2-(4-aMino-5-Methyl-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol

4-AMino-1-(4-hydroxy-5-hydroxyMethyl-tetrahydro-furan-2-yl)-5-Methyl-1H-pyriMidin-2-one

4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidin-2(1H)-one

5-Me-dC

5-Methyl-2'-deoxycytidine Solution, 100ppm

5-Methyl-2'-deoxycytidine≥ 99% (HPLC)

5-Methyl-2'-deoxycytidine, >=99%

Deoxy methylcytidine

2'-Deoxy-5-methylcytidine&gt

5MedCyd

5-mdC

5-Methyl-2'-deoxycytidine USP/EP/BP

5-methyl-2'-deoxycytidine(5-Me-dC)

5-Methyl-2'-deoxycytidine

2'-Deoxy-5-methylcytidine

2'-Deoxy-5-Mecytidine

838-07-3

C10H15N3O4

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

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Biochemistry

Nucleosides and their analogs

Nucleosides, Nucleotides & Related Reagents