Methyl 4-bromopyrrole-2-carboxylate
- Product Name
- Methyl 4-bromopyrrole-2-carboxylate
- CAS No.
- 934-05-4
- Chemical Name
- Methyl 4-bromopyrrole-2-carboxylate
- Synonyms
- METHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE;4-Bromo-1H-pyrrole-2-carboxylic acid methyl ester;RARECHEM AL BF 1264;METHYL 4-BROMOPYRROLE-2-CARBOXYLATE;4-Bromo-2-(methoxycarbonyl)-1H-pyrrole;Methyl 4-Bromopyrrole-2-carboxylate >Methyl 4-BroMopyrrole-2-carboxylate, 97+%;Methyl 4-bromo-1H-pyrrole-2-carboxylate 97+%;4-Bromopyrrole-2-carboxylic Acid Methyl Ester;Methyl 4-bromopyrrole-2-carboxylate, 10 mM in DMSO
- CBNumber
- CB1136108
- Molecular Formula
- C6H6BrNO2
- Formula Weight
- 204.02
- MOL File
- 934-05-4.mol
Methyl 4-bromopyrrole-2-carboxylate Property
- Melting point:
- 100-101°C
- Boiling point:
- 290.5±20.0 °C(Predicted)
- Density
- 1.674±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 13.49±0.50(Predicted)
- color
- White to Orange to Green
- λmax
- 271nm(MeOH)(lit.)
- InChI
- InChI=1S/C6H6BrNO2/c1-10-6(9)5-2-4(7)3-8-5/h2-3,8H,1H3
- InChIKey
- ZXFCRVGOHJHZNF-UHFFFAOYSA-N
- SMILES
- N1C=C(Br)C=C1C(OC)=O
- CAS DataBase Reference
- 934-05-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2583
- Product name
- Methyl 4-Bromopyrrole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- M2583
- Product name
- Methyl 4-Bromopyrrole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $135
- Updated
- 2025/07/31
- Product number
- B687160
- Product name
- 4-Bromo-1H-pyrrole-2-carboxylicAcidMethylEster
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- V0694
- Product name
- Methyl 4-Bromopyrrole-2-carboxylate
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- OR15416
- Product name
- Methyl4-bromo-1H-pyrrole-2-carboxylate
- Purity
- 97+%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
Methyl 4-bromopyrrole-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
4-Bromo-1H-pyrrole-2-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is used to synthesize potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone.
Synthesis
67-56-1
72652-32-5
124-41-4
934-05-4
Example 1C. Synthesis of 4-bromo-2-methoxycarbonylpyrrole: To a solution of methanol (100 mL) containing 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone (20 g, 68 mmol) was added slowly and dropwise sodium methanol (1M solution in methanol, 34 mL, 34 mmol). The reaction mixture was stirred at room temperature for 1 hour and then diluted with water (300 mL) to separate the organic layer. The aqueous phase was extracted with dichloromethane (CH2Cl2), and the combined organic layer and extract were washed with water (2 x 50 mL), dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure. The residue was recrystallized by hexane to give 4-bromo-2-methoxycarbonylpyrrole (12 g, 85% yield) as a white solid.LC-MS analysis showed [M-H]+ peak at 203.1.1.1H NMR (DMSO-d6, 400 MHz) data were as follows: δ 12.31 (broad single peak, 1H), 7.16 (single peak, 1H), 6.81 (single peak, 1H ), 3.75 (single peak, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4412 - 4418
[2] Patent: WO2010/42682, 2010, A1. Location in patent: Page/Page column 50
[3] Patent: US2006/293320, 2006, A1. Location in patent: Page/Page column 25; 35
Methyl 4-bromopyrrole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-bromopyrrole-2-carboxylate Suppliers
- Tel
- 0531-58620866 18205419756
- shy96321@163.com
- Country
- China
- ProdList
- 22
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 2274
- Advantage
- 58
- Tel
- 021-20960837
- Fax
- 021-20960837
- market@aloespharm.com
- Country
- China
- ProdList
- 1302
- Advantage
- 55
- Tel
- 13706129682
- tiffany@langyupharm.com
- Country
- China
- ProdList
- 84
- Advantage
- 58
- Tel
- 15209235325 18669728830
- 865681093@qq.com
- Country
- China
- ProdList
- 501
- Advantage
- 58
- Tel
- 0532-13853286203 13853286203
- shy96321@163.com
- Country
- China
- ProdList
- 61
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
View Lastest Price from Methyl 4-bromopyrrole-2-carboxylate manufacturers
- Product
- Methyl 4-bromo-1H-pyrrole-2-carboxylate 934-05-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- Methyl 4-bromopyrrole-2-carboxylate 934-05-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Methyl 4-bromopyrrole-2-carboxylate 934-05-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25