ChemicalBook > CAS DataBase List > TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

Product Name: TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
CAS No.: 398491-61-7
Chemical Name: TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
Synonyms: 4H;6-dimethyl-4;6H)-carboxylate;4-c]pyrazole-5(1H;6-dihydropyrrolo[3;6-diMethylpyrrolo[3;tert-butyl 3-aMino-6;6H)-carboxylatetertbutyl;4-c]pyrazole-5(1H)-carboxylate;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid
CBNumber: CB1138788
Molecular Formula: C12H20N4O2
Formula Weight: 252.31
MOL File: 398491-61-7.mol

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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Property

Boiling point:: 420.6±45.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 16.38±0.40(Predicted)
form: crystals
color: White
InChI: InChI=1S/C12H20N4O2/c1-11(2,3)18-10(17)16-6-7-8(12(16,4)5)14-15-9(7)13/h6H2,1-5H3,(H3,13,14,15)
InChIKey: XOQXOJPUZGHMLL-UHFFFAOYSA-N
SMILES: N1=C(N)C2CN(C(OC(C)(C)C)=O)C(C)(C)C=2N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B750313
Product name: tert-Butyl3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B750313
Product name: tert-Butyl3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148679
Product name: tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148679
Product name: tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148679
Product name: tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

946497-94-5

398491-61-7

Tert-butyl 4-cyano-2,2-dimethyl-3-oxopyrrolidine-1-carboxylate (11.5 g, 48.2 mmol) was used as a raw material and dissolved in ethanol (300 mL). To this solution was added hydrazine hydrochloride (4.95 g, 72.4 mmol) and the reaction mixture was stirred at 85 °C for 18 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. The concentrated residue was dissolved in ethyl acetate (200 mL) and washed with saturated aqueous sodium bicarbonate. The aqueous phase was dried with magnesium sulfate and again concentrated under vacuum. The product was purified by column chromatography (eluent: ethyl acetate solution containing 3% methanol) to give tert-butyl 3-amino-6,6-dimethylpyrrolo[3,4-C]pyrazole-5(1H,4H,6H)-5-carboxylate (5.5 g, 46% yield) as an off-white solid. The product was characterized by 1H NMR (DMSO-d6) with chemical shifts δ 11.12 (s, 1H), 5.05 (s, 2H), 4.11-4.07 (m, 2H), 1.50-1.48 (m, 6H), 1.44-1.41 (m, 9H).

References

[1] Patent: WO2013/91773, 2013, A1. Location in patent: Page/Page column 81
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2107 - 2150

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Suppliers

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View Lastest Price from TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE 398491-61-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 2000
Release date: 2025-09-25

Career Henan Chemical Co

Product: TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE 398491-61-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-08-07

398491-61-7, TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATERelated Search:

2-Bromoethanol Pyrrole N-Methylpropionamide ACETONE-D6 2,6-Dimethylaniline N,N-Dimethylaniline tert-butyl 3-aminopyrazole-l- carboxylate 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester TERT-BUTYL 3'-AMINO-1'H-SPIRO[CYCLOPROPANE-1,6'-PYRROLO[3,4-C]PYRAZOLE]-5'(4'H)-CARBOXYLATE TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate

6H)-carboxylatetertbutyl

3-Amino-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, N5-BOC protected

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

tert-butyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate

3-AMino-6,6-diMethyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

butyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate

4-c]pyrazole-5(1H

6-diMethylpyrrolo[3

6H)-carboxylate

tert-butyl 3-aMino-6

Tert-butyl 3-aMino-6,6-di-Methylpyrrolo[3,4-c]pyrazole-5(1H,4H,6

tert-Butyl 3-aMino-6,6-diMethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxyl

tert-butyl 3-aMino-6,6-diMethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylicacid, 3-aMino-4,6-dihydro-6,6-diMethyl-, 1,1-diMethylethyl ester

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid

tert-butyl 3-aMino-6,6-diMethylpyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate

3-Amino-5-Boc-6,6-dimethyl-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole

tert-butyl 3-amino-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate

3-Amino-5-Boc-6,6-dimethyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole

3-Amino-5-Boc-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

4-c]pyrazole-5(1H)-carboxylate

6-dihydropyrrolo[3

6-dimethyl-4

tert-Butyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyr...

tert-butyl 6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

398491-61-7

8491-61-7

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