ChemicalBook > CAS DataBase List > TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

Product Name
TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
CAS No.
398491-61-7
Chemical Name
TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
Synonyms
4H;6-dimethyl-4;6H)-carboxylate;4-c]pyrazole-5(1H;6-dihydropyrrolo[3;6-diMethylpyrrolo[3;tert-butyl 3-aMino-6;6H)-carboxylatetertbutyl;4-c]pyrazole-5(1H)-carboxylate;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid
CBNumber
CB1138788
Molecular Formula
C12H20N4O2
Formula Weight
252.31
MOL File
398491-61-7.mol
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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Property

Boiling point:
420.6±45.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
16.38±0.40(Predicted)
form 
crystals
color 
White
InChI
InChI=1S/C12H20N4O2/c1-11(2,3)18-10(17)16-6-7-8(12(16,4)5)14-15-9(7)13/h6H2,1-5H3,(H3,13,14,15)
InChIKey
XOQXOJPUZGHMLL-UHFFFAOYSA-N
SMILES
N1=C(N)C2CN(C(OC(C)(C)C)=O)C(C)(C)C=2N1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B750313
Product name
tert-Butyl3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B750313
Product name
tert-Butyl3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148679
Product name
tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148679
Product name
tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging
250mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148679
Product name
tert-Butyl3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
Packaging
500mg
Price
$150
Updated
2021/12/16
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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

946497-94-5

398491-61-7

Tert-butyl 4-cyano-2,2-dimethyl-3-oxopyrrolidine-1-carboxylate (11.5 g, 48.2 mmol) was used as a raw material and dissolved in ethanol (300 mL). To this solution was added hydrazine hydrochloride (4.95 g, 72.4 mmol) and the reaction mixture was stirred at 85 °C for 18 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. The concentrated residue was dissolved in ethyl acetate (200 mL) and washed with saturated aqueous sodium bicarbonate. The aqueous phase was dried with magnesium sulfate and again concentrated under vacuum. The product was purified by column chromatography (eluent: ethyl acetate solution containing 3% methanol) to give tert-butyl 3-amino-6,6-dimethylpyrrolo[3,4-C]pyrazole-5(1H,4H,6H)-5-carboxylate (5.5 g, 46% yield) as an off-white solid. The product was characterized by 1H NMR (DMSO-d6) with chemical shifts δ 11.12 (s, 1H), 5.05 (s, 2H), 4.11-4.07 (m, 2H), 1.50-1.48 (m, 6H), 1.44-1.41 (m, 9H).

References

[1] Patent: WO2013/91773, 2013, A1. Location in patent: Page/Page column 81
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2107 - 2150

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE Suppliers

China 109 China Hong Kong 1 Germany 1 India 1 United Kingdom 2 United States 13 Global 127
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
--
Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
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View Lastest Price from TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE 398491-61-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
2000
Release date
2025-09-25
Career Henan Chemical Co
Product
TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE 398491-61-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-08-07

398491-61-7, TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATERelated Search:

2-Bromoethanol Pyrrole N-Methylpropionamide ACETONE-D6 2,6-Dimethylaniline N,N-Dimethylaniline tert-butyl 3-aminopyrazole-l- carboxylate 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester TERT-BUTYL 3'-AMINO-1'H-SPIRO[CYCLOPROPANE-1,6'-PYRROLO[3,4-C]PYRAZOLE]-5'(4'H)-CARBOXYLATE TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

  • 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
  • 6H)-carboxylatetertbutyl
  • 3-Amino-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, N5-BOC protected
  • TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE
  • tert-butyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
  • 3-AMino-6,6-diMethyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
  • butyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate
  • 4-c]pyrazole-5(1H
  • 4H
  • 6-diMethylpyrrolo[3
  • 6H)-carboxylate
  • tert-butyl 3-aMino-6
  • Tert-butyl 3-aMino-6,6-di-Methylpyrrolo[3,4-c]pyrazole-5(1H,4H,6
  • tert-Butyl 3-aMino-6,6-diMethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxyl
  • tert-butyl 3-aMino-6,6-diMethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate
  • Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylicacid, 3-aMino-4,6-dihydro-6,6-diMethyl-, 1,1-diMethylethyl ester
  • Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid
  • tert-butyl 3-aMino-6,6-diMethylpyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate
  • 3-Amino-5-Boc-6,6-dimethyl-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole
  • tert-butyl 3-amino-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate
  • 3-Amino-5-Boc-6,6-dimethyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole
  • 3-Amino-5-Boc-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
  • 4-c]pyrazole-5(1H)-carboxylate
  • 6-dihydropyrrolo[3
  • 6-dimethyl-4
  • tert-Butyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyr...
  • tert-butyl 6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate
  • 398491-61-7
  • 8491-61-7
  • CHIRAL CHEMICALS