3-HYDROXY-4-BENZYLOXY BENZALDEHYDE

Product Name: 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
CAS No.: 4049-39-2
Chemical Name: 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
Synonyms: 4-BENZLOXY-3-HYDROXYBENZALDEHYDE;4-BENZLOXY-3-HYDROXYBENZALDEHYLE;4-BENZYLOXY-3-HYDROXYBENZALDEHYDE;4-HYDROXY-4-BENZYLOXYBENZALDEHYDE;3-HYDROXY-4-BENZYLOXY BENZALDEHYDE;Protocatechuic Aldehyde-4-benzyl Ether;3-Hydroxy-4-(phenylmethoxy)benzaldehyde;Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-;4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde
CBNumber: CB1140624
Molecular Formula: C14H12O3
Formula Weight: 228.24
MOL File: 4049-39-2.mol

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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Property

Melting point:: 120 °C(Solv: ethanol (64-17-5))
Boiling point:: 403.3±30.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 8.79±0.35(Predicted)
color: Off-White to Light Brown
InChI: InChI=1S/C14H12O3/c15-9-12-6-7-14(13(16)8-12)17-10-11-4-2-1-3-5-11/h1-9,16H,10H2
InChIKey: HUNGEAFDVLSPAM-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OCC2=CC=CC=C2)C(O)=C1
CAS DataBase Reference: 4049-39-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B286355
Product name: 4-Benzyloxy-3-hydroxybenzaldehyde
Packaging: 2.5g
Price: $645
Updated: 2021/12/16

AK Scientific

Product number: 5454CC
Product name: 4-(Benzyloxy)-3-hydroxybenzaldehyde
Packaging: 5g
Price: $737
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18456
Product name: 4-Benzyloxy-3-hydroxybenzaldehyde
Packaging: 5G
Price: $525.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010517
Product name: 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
Purity: 95.00%
Packaging: 2G
Price: $907.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18456
Product name: 4-Benzyloxy-3-hydroxybenzaldehyde
Packaging: 1g
Price: $155
Updated: 2021/12/16

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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

4-Benzyloxy-3-hydroxybenzaldehyde is useful for preparing quinazoline derivatives.

Synthesis

100-39-0

139-85-5

4049-39-2

To a solution of 3,4-dihydroxybenzaldehyde (2.03 g, 14.7 mmol) in acetone (150 mL) was added potassium carbonate (K2CO3, 3.05 g, 22.1 mmol) and benzyl bromide (1.74 mL, 14.7 mmol). The reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite? 535RVS and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography using toluene/ethyl acetate (13:1, v/v) as eluent to afford 4-(benzyloxy)-3-hydroxybenzaldehyde (2.12 g, 63% yield) as colorless prismatic crystals. The product characterization data were as follows: 1H NMR (300 MHz, CDCl3) δ 5.21 (2H, s), 5.77 (1H, s), 7.05 (1H, d, J = 8.2 Hz), 7.37-7.43 (7H, m), 9.86 (1H, s); 13C NMR (75 MHz, CDCl3) δ 71.2, 111.5, 114.4, 124.4, 127.9, 128.8, 128.9, 130.8, 135.2, 146.3, 150.9, 191.0; IR (ATR) νmax 3201, 1671, 1604, 1577, 1511, 1454, 1389, 1343, 1283, 1165, 1151, 1015 , 962, 874, 811, 786, 738, 698, 678 cm-1; EIMS m/z (relative intensity) 228 [M]+ (40), 91 (100); HR-EIMS m/z: [M]+ calculated C14H12O3 228.0786, measured 228.0789; melting point 120.0-122.0°C.

References

[1] Patent: WO2014/149793, 2014, A1. Location in patent: Page/Page column 59-60; 93; 96
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 22, p. 4693 - 4711
[3] Chemistry - A European Journal, 1998, vol. 4, # 1, p. 33 - 43
[4] Journal of Natural Products, 2018, vol. 81, # 2, p. 371 - 377
[5] Organic Letters, 2012, vol. 14, # 15, p. 3902 - 3905

3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Suppliers

Canada 1 China 46 India 2 United Kingdom 6 United States 7 Global 62

Hebei Maipu Technology Co., LTD

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Nanjing KaiMubo Pharmaceutical Co., Ltd.

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View Lastest Price from 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-15

Shaanxi Dideu Medichem Co. Ltd

Product: 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
Price: US $3.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-29

4049-39-2, 3-HYDROXY-4-BENZYLOXY BENZALDEHYDERelated Search:

4-BENZYLOXY-3-METHOXYACETOPHENONE 3,4-Dibenzyloxybenzaldehyde 3,5-dimethoxy-4-phenylmethoxy-benzoate FUMARPROTOCETRARIC ACID 4-BENZYLOXY-3-METHOXYBENZALDEHYDE 4-Benzyloxybenzaldehyde 4-BENZYLOXY-3-METHOXYBENZOIC ACID 4-[(4-FLUOROBENZYL)OXY]-3-METHOXYBENZENECARBALDEHYDE 3-METHOXY-4-[(4-METHOXYBENZYL)OXY]BENZENECARBALDEHYDE METHYL 7-METHOXY-2,2-DIPHENYL-1,3-BENZODIOXOLE-5-CARBOXYLATE 3-METHOXY-4-(P-NITROBENZYLOXY)BENZALDEHYDE METHYL 4-BENZYLOXY-3-METHOXYBENZOATE 4-FORMYL-2-METHOXYPHENYL BENZOATE STICTIC ACID 4-FORMYL-2-METHOXYPHENYL 3,4,5-TRIMETHOXYBENZOATE 7-HYDROXY-2,2-DIPHENYL-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER 3,4,5-TRIBENZOYLOXYBENZOIC ACID N-PROPYL ESTER 4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE

4-BENZYLOXY-3-HYDROXYBENZALDEHYDE

3-HYDROXY-4-BENZYLOXY BENZALDEHYDE

4-HYDROXY-4-BENZYLOXYBENZALDEHYDE

4-BENZLOXY-3-HYDROXYBENZALDEHYLE

4-BENZLOXY-3-HYDROXYBENZALDEHYDE

3-Hydroxy-4-(phenylmethoxy)benzaldehyde

Protocatechuic Aldehyde-4-benzyl Ether

4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde

Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-

4049-39-2

Aromatics