L-AP4

Product Name: L-AP4
CAS No.: 23052-81-5
Chemical Name: L-AP4
Synonyms: GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;L-AP4, group III mGlu agonist
CBNumber: CB1141944
Molecular Formula: C4H10NO5P
Formula Weight: 183.1
MOL File: 23052-81-5.mol

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L-AP4 Property

Melting point:: 207-215 °C
Boiling point:: 491.7±55.0 °C(Predicted)
Density: 1.628±0.06 g/cm3(Predicted)
storage temp.: 0-6°C
solubility: H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
pka: 2.19±0.10(Predicted)
form: solid
color: White
Water Solubility: Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
Sensitive: Light Sensitive
CAS DataBase Reference: 23052-81-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: ES7191700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7929
Product name: L-(+)-2-Amino-4-phosphonobutyric acid
Purity: optical purity optical purity: ≥95% (HPLC, Marfey′s reagent)
Packaging: 0.5mg
Price: $103
Updated: 2024/03/01

Sigma-Aldrich

Product number: SRP4667
Product name: GDF-5 human
Purity: recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Packaging: 50μG
Price: $316
Updated: 2022/05/15

Sigma-Aldrich

Product number: 165300
Product name: L-(+)-2-Amino-4-phosphonobutyric Acid
Packaging: 1mg
Price: $88.3
Updated: 2022/05/15

Alfa Aesar

Product number: J64075
Product name: (S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
Packaging: 1mg
Price: $93.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64075
Product name: (S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
Packaging: 10mg
Price: $216.65
Updated: 2024/03/01

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L-AP4 Chemical Properties,Usage,Production

Description

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC₅₀ = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Chemical Properties

white to off-white crystalline powder

Uses

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Uses

L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist.

Definition

ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids.

Biological Activity

Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

storage

Room temperature

L-AP4 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-AP4 Suppliers

Belgium 1 China 56 Germany 2 India 1 Japan 2 Switzerland 3 United Kingdom 8 United States 23 USA 1 Global 97

EMMX Biotechnology LLC

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View Lastest Price from L-AP4 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-AP4 23052-81-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: L-AP4 23052-81-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

23052-81-5, L-AP4Related Search:

12AP 4-PHOSPHONOBUTYRIC ACID 3-Aminopropylphosphonic acid (S)-2-Amino-2-methyl-4-phosphonobutanoic acid DL-2-AMINO-4-PHOSPHONOBUTYRIC ACID ANTI-IMMUNOGLOBULIN A, HUMAN, AP ANTI-IGG, MOUSE AP CONJ ANTI-IGM MU-CHAIN, RAT AP CONJ ANTI-IGG H AND L CHAIN, GOAT AP CONJ ANTI-IGG, HUMAN AP CONJ ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ 16-AP ANTI-IGG H AND L CHAIN, HUMAN AP CONJ,ANTI-IGG(H+L), HUMAN AP CONJ ANTI-IGG H AND L CHAIN, RABBIT AP CONJ,ANTI-IGG(H+L), RABBIT AP CONJ ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP ANTI-IGG H AND L CHAIN, HORSE AP CONJ L-AP4 ANTI-IGG H AND L CHAIN, SHEEP AP CONJ

L-AP4

L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID

L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID

L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4)

L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%

(2S)-2-Amino-4-phosphonobutyric acid

(S)-4-Phosphono-2-aminobutanoic acid

(S)-4-Phosphono-2-aminobutyric acid

L-APB

L(+)-2-Amino-4-phosphonobutyric acid,97%

(S)-2-aMino-4-phosphonobutanoic acid

GDF-5 human

SYNS2

BMP-14 (GDF-5/CDMP-1) human

BMP-14/ CDMP-1

GDF-5 mouse

Anti-GDF5 (C-terminal) antibody produced in rabbit

CDMP1

GDF5

L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4)

2-ammonio-4-phosphonatobutanoate

L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem

(2S)-2-amino-4-phosphonobutanoic acid

Butanoic acid, 2-amino-4-phosphono-, (2S)-

L-AP4, group III mGlu agonist

L-AP4 (mM/ml), group III mGlu agonist

23052-81-5

C4H10NO5P

mGluR4 and mGluR6 metabotropic glutamate receptor agonist.

Glutamate receptor

Glutamate