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DEOXYLIMONIN

Product Name
DEOXYLIMONIN
CAS No.
989-23-1
Chemical Name
DEOXYLIMONIN
Synonyms
NSC 314317;DEOXYLIMONIN;desoxylimonin;Deoxylimonin, 10 mM in DMSO;anticancer,Inhibitor,anti-inflammation,antinociception,Deoxylimonin,inhibit,MCF-7;(2AS,6aR,6bR,8aR,9R,12bR,14aR)-9-(furan-3-yl)-1,1,8a,12b-tetramethyl-2a,3,6b,7,8,8a,9,12b,14,14a-decahydro-4H,6H,11H-pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-4,11,13(1H)-trione;(2AS,6aR,6bR,8aR,9R,12bR,14aR)-9-(furan-3-yl)-1,1,8a,12b-tetramethyl-2a,3,6b,7,8,8a,9,12b,14,14a-decahydro-4H,6H,11H-pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-4,11,13(1H)-trione;4H,6H,8H-Pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,11,13(7H,14H)-trione, 9-(3-furanyl)-1,2a,3,6b,8a,9,12b,14a-octahydro-1,1,8a,12b-tetramethyl-, (2aS,6aR,6bR,8aR,9R,12bR,14aR)- (9CI)
CBNumber
CB11422220
Molecular Formula
C26H30O7
Formula Weight
454.5122
MOL File
989-23-1.mol
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DEOXYLIMONIN Property

storage temp. 
4°C, protect from light
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
7254CA
Product name
Desoxylimonin
Packaging
2mg
Price
$293
Updated
2021/12/16
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DEOXYLIMONIN Chemical Properties,Usage,Production

Uses

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].

Definition

ChEBI: Desoxylimonin is a steroid lactone.

in vivo

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo[1].

Animal Model:Mice injected with acetic acid[1]
Dosage:70 mg/kg
Administration:Oral administration; 70 mg/kg; once
Result:Showed the antinociception efficacy (writhing inhibition rate: 24.61%).

References

[1] Shaochi Wang, et al. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs. Bioorg Chem. 2020 Jul;100:103886. DOI:10.1016/j.bioorg.2020.103886
[2] N. Guthri, et al. Inhibition of Human Breast Cancer Cells by Citrus Limonoids. ACS Symposium SeriesVol. 758, July 30, 2000.

DEOXYLIMONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DEOXYLIMONIN Suppliers

China 38 United States 2 Global 40
ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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0086-21-51320502
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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Shanghai Yihe Biological Technology Co., Ltd.
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Henan Alfachem Co.,Ltd.
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989-23-1, DEOXYLIMONINRelated Search:

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  • DEOXYLIMONIN
  • desoxylimonin
  • 4H,6H,8H-Pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,11,13(7H,14H)-trione, 9-(3-furanyl)-1,2a,3,6b,8a,9,12b,14a-octahydro-1,1,8a,12b-tetramethyl-, (2aS,6aR,6bR,8aR,9R,12bR,14aR)- (9CI)
  • NSC 314317
  • anticancer,Inhibitor,anti-inflammation,antinociception,Deoxylimonin,inhibit,MCF-7
  • (2AS,6aR,6bR,8aR,9R,12bR,14aR)-9-(furan-3-yl)-1,1,8a,12b-tetramethyl-2a,3,6b,7,8,8a,9,12b,14,14a-decahydro-4H,6H,11H-pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-4,11,13(1H)-trione
  • Deoxylimonin, 10 mM in DMSO
  • (2AS,6aR,6bR,8aR,9R,12bR,14aR)-9-(furan-3-yl)-1,1,8a,12b-tetramethyl-2a,3,6b,7,8,8a,9,12b,14,14a-decahydro-4H,6H,11H-pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-4,11,13(1H)-trione
  • 989-23-1