1-Amino-2-methylpropan-2-ol
- Product Name
- 1-Amino-2-methylpropan-2-ol
- CAS No.
- 2854-16-2
- Chemical Name
- 1-Amino-2-methylpropan-2-ol
- Synonyms
- 1-Amino-2-methyl-2-propanol;EOS-60808;NSC 17697;1-amino-2-methyL;TIANFU-CHEM 2854-16-2;2-Hydroxyisobutylamine;1,1-Dimethylethanolamine;-Amino-2-methylpropan-2-ol;2-Amino-a,a-dimethylethanol;1-Amino-2-methylpropan-2-ol
- CBNumber
- CB11454713
- Molecular Formula
- C4H11NO
- Formula Weight
- 89.14
- MOL File
- 2854-16-2.mol
1-Amino-2-methylpropan-2-ol Property
- Melting point:
- 8.72°C (estimate)
- Boiling point:
- 151°C(lit.)
- Density
- 1.915 g/mL at 25 °C
- refractive index
- n20/D1.448
- Flash point:
- 73℃
- storage temp.
- 2-8°C
- solubility
- Chloroform, Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 12.99±0.50(Predicted)
- color
- Clear Colourless
- InChI
- InChI=1S/C4H11NO/c1-4(2,6)3-5/h6H,3,5H2,1-2H3
- InChIKey
- LXQMHOKEXZETKB-UHFFFAOYSA-N
- SMILES
- C(N)C(C)(O)C
- CAS DataBase Reference
- 2854-16-2
- NIST Chemistry Reference
- 1-Amino-2-methyl-2-propanol(2854-16-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- 1993
- WGK Germany
- 3
- RTECS
- UA6125000
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- CDS007515
- Product name
- 1-Amino-2-methylpropan-2-ol
- Purity
- AldrichCPR
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- 777625
- Product name
- 1-Amino-2-methyl-2-propanol
- Purity
- 95% anhydrous basis
- Packaging
- 1g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- A2442
- Product name
- 1-Amino-2-methyl-2-propanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- A2442
- Product name
- 1-Amino-2-methyl-2-propanol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $205
- Updated
- 2025/07/31
- Product number
- A617430
- Product name
- 3-Amino-2-methyl-2-propanol
- Packaging
- 10g
- Price
- $1135
- Updated
- 2021/12/16
1-Amino-2-methylpropan-2-ol Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
3-Amino-2-methyl-2-propanol, is a versatile intermediate used for the synthesis of more complex compounds, including inhibitors. It is an intermediate in the preparation of metabolites of Darunavir (D193500), such as (A581405).
Synthesis
75-86-5
2854-16-2
The general procedure for the synthesis of 1-amino-2-methyl-2-propanol from acetone cyanohydrin is as follows: Step A: Synthesis of 1-amino-2-methyl-2-propanol [Chem.17] To a tetrahydrofuran (180 mL) suspension of lithium aluminum hydride (6.08 g, 160 mmol), a tetrahydrofuran (20 mL) solution of acetone cyanohydrin (7.32 mL, 80.0 mmol) was slowly added dropwise over a controlled period of 15 min at 0 °C. The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with sodium sulfate decahydrate and potassium fluoride. After continued stirring at 35°C for 30 minutes, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give the oily product 1-amino-2-methyl-2-propanol (3.98 g, 56% yield). [0229] 1H-NMR (300 MHz, CDCl3) δ: 2.60 (s, 2H), 1.69 (s, 6H), no peaks for OH and NH2 were observed.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4336 - 4351
[2] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 50-51
[3] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7319 - 7322
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 18, p. 3347 - 3359
[5] Patent: EP1591446, 2005, A1. Location in patent: Page/Page column 96
1-Amino-2-methylpropan-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Amino-2-methylpropan-2-ol manufacturers
- Product
- 1-Amino-2-methylpropan-2-ol 2854-16-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- 1-Amino-2-methylpropan-2-ol 2854-16-2
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- 97%
- Supply Ability
- 500g 1kg 5kg 10kg 25kg 50kg...
- Release date
- 2019-02-13
- Product
- 1-Amino-2-methylpropan-2-ol 2854-16-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-19