Dovitinib
- Product Name
- Dovitinib
- CAS No.
- 405169-16-6
- Chemical Name
- Dovitinib
- Synonyms
- CS-226;TKI-258;CHIR-258;dovitinib;PDovitinib;NCGC00249685;CHIR258 7.7G;Dovitinib base;Unii-I35H55G906;TKI258; CHIR-258
- CBNumber
- CB11512534
- Molecular Formula
- C21H21FN6O
- Formula Weight
- 392.43
- MOL File
- 405169-16-6.mol
Dovitinib Property
- Density
- 1.386
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- pka
- 9.44±0.70(Predicted)
- form
- solid
- color
- Yellow-green
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 405169-16-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15220
- Product name
- Dovitinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 15220
- Product name
- Dovitinib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 15220
- Product name
- Dovitinib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $313
- Updated
- 2024/03/01
- Product number
- 15220
- Product name
- Dovitinib
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- orb154678
- Product name
- Dovitinib (TKI258, CHIR258)
- Purity
- >99%
- Packaging
- 100mg
- Price
- $606.9
- Updated
- 2021/12/16
Dovitinib Chemical Properties,Usage,Production
Description
Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Dovitinib selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Uses
Compound used in treating melanoma
Uses
Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.
Uses
Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
Uses
Dovitinib is a receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor-2, basic fibroblast growth factor-1, and platelet-derived growth factor β receptors (IC50s = 65, 11, and 5 nM, respectively). At 0.04 μM, dovitinib can inhibit endothelial cell proliferation and motility. These antiangiogenic effects have been proposed to be the mechanism by which dovitinib inhibits hepatocellular carcinoma growth and metastasis. Dovitinib has been evaluated in clinical trials for the treatment of advanced solid tumors.
Definition
ChEBI: 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone is a N-arylpiperazine.
in vivo
the combination of tigatuzumab and tki258 inhibited huh-7 xenograft tumor growth [3]. tki258 reduced wm tumor progression [4].
target
FLT3
References
1) Lee et al. (2005), In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models; Clin. Cancer Res., 11 3633 2) Xin et al. (2006), CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice; Clin. Cancer Res., 12 4908
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View Lastest Price from Dovitinib manufacturers
- Product
- Dovitinib 405169-16-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one 405169-16-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24