Fosaprepitant

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Product Name: Fosaprepitant
CAS No.: 172673-20-0
Chemical Name: Fosaprepitant
Synonyms: L 758298;Fosaprepitant;Fosaprepitant D4;MK-0517 (Fosaprepitant);Fosaprepitant See F727305;Fosaprepitant (See also F727305);[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid;[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid;P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid;Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-
CBNumber: CB11515191
Molecular Formula: C23H22F7N4O6P
Formula Weight: 614.41
MOL File: 172673-20-0.mol

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Fosaprepitant Property

Melting point:: >74°C (dec.)
Density: 1.65
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO, Methanol
pka: 2.45±0.20(Predicted)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1272
Product name: Fosaprepitant
Packaging: 25mg
Price: $323
Updated: 2021/12/16

ApexBio Technology

Product number: B1272
Product name: Fosaprepitant
Packaging: 50mg
Price: $485
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 250mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134399
Product name: Fosaprepitant
Purity: >99%
Packaging: 1g
Price: $1504.5
Updated: 2021/12/16

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Fosaprepitant Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Uses

Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.

Uses

An antiemetic drug, a Aprepitant prodrug.

Definition

ChEBI: A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triaz l-1-yl)phosphonic acid.

Biological Activity

fosaprepitant (l-758,298 mk-0517) is an antagonist of neurokinin-1[1].fosaprepitant has shown the pharmacodynamic function by its active metabolite aprepitant. fosaprepitanot has been found to be a highly selective antagonist of the nk-1 receptor and inhibit the cation of substance p. in addition, fosaprepitant has been exhibited to have the effect on cisplatin induced emesis in the classical ferret model. besides, because of the brain penetrating of aprepitant, fosaprepitant has been revealed to have a very high affinity for the nk-1 receptor and increase the efficacy by dexamethasone, granisetron and so on. fosaprepitant has been evaluated to use in the prevention of chemotherapy-induced nausea and vomiting (cinv) by combination with a 5-ht3 antagonist and a steroid [1].

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: avoid with St John’s wort.
Antipsychotics: avoid with pimozide.
Cytotoxics: possibly increases bosutinib concentration - avoid or reduce bosutinib dose.
Oestrogens and progestogens: may cause contraceptive failure.

Metabolism

Fosaprepitant is a prodrug and is rapidly metabolised to aprepitant. Aprepitant undergoes extensive hepatic metabolism, mainly via oxidation by the cytochrome P450 isoenzyme CYP3A4; the isoenzymes CYP1A2 and CYP2C19 mediate minor metabolic pathways. The resultant metabolites have weak activity and are excreted in the urine and in the faeces.

References

[1] van belle sj1, cocquyt v. fosaprepitant dimeglumine (mk-0517 or l-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting.expert opin pharmacother. 2008 dec; 9(18):3261-70.

Fosaprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fosaprepitant manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Fosaprepitant 172673-20-0
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-24

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: Fosaprepitant 172673-20-0
Price: US $100.00/KG
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Purity: 99%
Supply Ability: 1000 Kilogram/Kilograms per Week
Release date: 2023-03-10

Wuhan Monad Medicine Tech Co.,LTD

Product: Fosaprepitant 172673-20-0
Price: US $10.00/KG
Min. Order: 1Kg/Bag
Purity: 99%min
Supply Ability: 20000
Release date: 2020-12-22

172673-20-0, FosaprepitantRelated Search:

Moroxydine hydrochloride Piracetam PHENYL VALERATE Diphenyl ether Moroxydine Dimethomorph Zolpidem tartrate Voriconazole PHENYL RESIN Fosaprepitant Impurity 9 Fosaprepitant Impurity 11 Fosaprepitant Impurity 17 Fosaprepitant Impurity 14 Aprepitant fosaprepitant dibenzyl ester Fosaprepitant Benzyl Ester Fosaprepitant dimeglumine Diphosphoric acid, tris(phenylmethyl) ester (9CI)

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid

[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid

L 758298

P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid

MK-0517 (Fosaprepitant)

D-Glucitol, 1-deoxy-1-(MethylaMino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- Morpholinyl)Methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1)

Fosaprepitant

Fosaprepitant (See also F727305)

Phosphonic acid, P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-

Fosaprepitant See F727305

Fosaprepitant D4

172673-20-0

C23H22F7N4O6P

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