Fosaprepitant
- Product Name
- Fosaprepitant
- CAS No.
- 172673-20-0
- Chemical Name
- Fosaprepitant
- Synonyms
- L 758298;Foxapitan;Fosaprepitant;Fosaprepitant D4;MK-0517 (Fosaprepitant);Fosaprepitant See F727305;Fosaprepitant (See also F727305);[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-2H-1,2,4-triazol-1-yl]phosphonic acid;[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid;P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid
- CBNumber
- CB11515191
- Molecular Formula
- C23H22F7N4O6P
- Formula Weight
- 614.41
- MOL File
- 172673-20-0.mol
Fosaprepitant Property
- Melting point:
- >74°C (dec.)
- Density
- 1.65
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO, Methanol
- pka
- 2.45±0.20(Predicted)
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B1272
- Product name
- Fosaprepitant
- Packaging
- 25mg
- Price
- $323
- Updated
- 2021/12/16
- Product number
- B1272
- Product name
- Fosaprepitant
- Packaging
- 50mg
- Price
- $485
- Updated
- 2021/12/16
- Product number
- orb134399
- Product name
- Fosaprepitant
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- orb134399
- Product name
- Fosaprepitant
- Purity
- >99%
- Packaging
- 250mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- orb134399
- Product name
- Fosaprepitant
- Purity
- >99%
- Packaging
- 1g
- Price
- $1504.5
- Updated
- 2021/12/16
Fosaprepitant Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
Uses
Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
Uses
An antiemetic drug, a Aprepitant prodrug.
Definition
ChEBI: A morpholine derivative that is the (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl ether of (3-{[(2R,3S)-3-(4-fluorophenyl)-2-hydroxymorpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triaz l-1-yl)phosphonic acid.
Biological Activity
fosaprepitant (l-758,298 mk-0517) is an antagonist of neurokinin-1[1].fosaprepitant has shown the pharmacodynamic function by its active metabolite aprepitant. fosaprepitanot has been found to be a highly selective antagonist of the nk-1 receptor and inhibit the cation of substance p. in addition, fosaprepitant has been exhibited to have the effect on cisplatin induced emesis in the classical ferret model. besides, because of the brain penetrating of aprepitant, fosaprepitant has been revealed to have a very high affinity for the nk-1 receptor and increase the efficacy by dexamethasone, granisetron and so on. fosaprepitant has been evaluated to use in the prevention of chemotherapy-induced nausea and vomiting (cinv) by combination with a 5-ht3 antagonist and a steroid [1].
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: avoid with St John’s wort.
Antipsychotics: avoid with pimozide.
Cytotoxics: possibly increases bosutinib
concentration - avoid or reduce bosutinib dose.
Oestrogens and progestogens: may cause
contraceptive failure.
Metabolism
Fosaprepitant is a prodrug and is rapidly metabolised to aprepitant. Aprepitant undergoes extensive hepatic metabolism, mainly via oxidation by the cytochrome P450 isoenzyme CYP3A4; the isoenzymes CYP1A2 and CYP2C19 mediate minor metabolic pathways. The resultant metabolites have weak activity and are excreted in the urine and in the faeces.
References
[1] van belle sj1, cocquyt v. fosaprepitant dimeglumine (mk-0517 or l-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting.expert opin pharmacother. 2008 dec; 9(18):3261-70.
Fosaprepitant Preparation Products And Raw materials
Raw materials
Preparation Products
Fosaprepitant Suppliers
- Tel
- --
- Fax
- --
- @pharmaffiliates.com
- Country
- India
- ProdList
- 6754
- Advantage
- 58
- Tel
- --
- Fax
- --
- standards@synzeal.com
- Country
- India
- ProdList
- 6514
- Advantage
- 58
- Tel
- --
- Fax
- --
- mktg@pharmaffiliates.com
- Country
- India
- ProdList
- 6739
- Advantage
- 58
View Lastest Price from Fosaprepitant manufacturers
- Product
- Fosaprepitant 172673-20-0
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-24
- Product
- Fosaprepitant 172673-20-0
- Price
- US $100.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 1000 Kilogram/Kilograms per Week
- Release date
- 2023-03-10
- Product
- Fosaprepitant 172673-20-0
- Price
- US $10.00/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99%min
- Supply Ability
- 20000
- Release date
- 2020-12-22