DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

ChemicalBook > CAS DataBase List > DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

Product Name: DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
CAS No.: 13515-99-6
Chemical Name: DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
Synonyms: utamate HydrochL;H-DL-Glu(Ome)-Ome;DL-Glu(OMe)-OMe.HCl;H-DL-GLU(OME)-OME HCL;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE;DimethylDL-GlutamateHydrochloride>imethyl2-aminopentanedioate,hydrochloride;dimethyl 2-aminopentanedioate hydrochloride;DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP
CBNumber: CB1152575
Molecular Formula: C7H14ClNO4
Formula Weight: 211.64
MOL File: 13515-99-6.mol

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DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Property

Melting point:: 154 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
CAS DataBase Reference: 13515-99-6

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Safety

HS Code: 2922.42.5000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3305
Product name: Dimethyl DL-Glutamate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $42
Updated: 2024/03/01

TCI Chemical

Product number: D3305
Product name: Dimethyl DL-Glutamate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 25g
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 18602
Product name: Dimethyl DL-Glutamate (hydrochloride)
Purity: ≥95%
Packaging: 5g
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 18602
Product name: Dimethyl DL-Glutamate (hydrochloride)
Purity: ≥95%
Packaging: 10g
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 18602
Product name: Dimethyl DL-Glutamate (hydrochloride)
Purity: ≥95%
Packaging: 25g
Price: $302
Updated: 2024/03/01

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DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

Uses

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

in vitro

dimethyl dl-glutamate at 3.0-10.0 mm could enhance insulin release evoked by 6.0-8.3 mm d-glucose, 1.0-10.0 mm l-leucine, or 5.0-10.0 mm 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and d-glucose concentration. moreover, dimethyl dl-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of d-glucose. in islets exposed to l-leucine, the insulinotropic action of dimethyl dl-glutamate coincided with an early fall and later increase in 86rb outflow. in addition, the overall gain in o2 uptake represented the balance between dimethyl dl-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous d-glucose [1].

in vivo

dimethyl dl-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. results showed that dimethyl dl-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glp-1 injected intravenously at min 5 of the test [2].

References

[1] sener, a. ,conget, i.,rasschaert, j., et al. insulinotropic action of glutamic acid dimethyl ester. american journal of physiology 267(4 pt 1), e573-e584 (1994).
[2] cancelas, j. ,villaneuva-peacarrillo, m.l.,valverde, i., et al. potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of l-glutamic acid in a type 2 diabetes animal model. endocrine 16(2), 113-116 (2001).

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIMETHYL DL-GLUTAMATE HYDROCHLORIDE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: DL-Glu(Ome)-Ome.Hcl 13515-99-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-23

Career Henan Chemical Co

Product: DIMETHYL DL-GLUTAMATE HYDROCHLORIDE 13515-99-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-22

13515-99-6, DIMETHYL DL-GLUTAMATE HYDROCHLORIDERelated Search:

H-DL-GLU(OME)-OH H-DL-Glu(OtBu)-NH2.HCl L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride DIMETHYL DL-GLUTAMATE HYDROCHLORIDE L-Glutamic acid dimethyl ester hydrochloride L-Glutamic acid di-tert-butyl ester hydrochloride H-D-GLU(OME)-OME HCL H-D-GLU(OTBU)-OTBU HCL H-GLU(OBZL)-OBZL HCL Diethyl L-glutamate hydrochloride H-GLU(OALL)-OALL P-TOSYLATE D-GLUTAMIC ACID(OTBU)-ALLYL ESTER HCL GLUTAMIC ACID(OTBU)-ALLYL ESTER HCL H-GLU(OME)-OTBU HCL H-D-GLU(OBZL)-OBZL HCL H-GLU(OBZL)-OTBU HCL KAINIC ACID DIMETHYL ESTER HYDROCHLORIDE DIETHYL 5-(4-CHLOROPHENYL)-2,4-PYRROLIDINEDICARBOXYLATE

DL-GLUTAMIC ACID ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE

DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

H-DL-GLU(OME)-OME HCL

dimethyl 2-aminopentanedioate hydrochloride

DL-Glutamic Acid Dimethyl Ester Hydrochloride H-DL-Glu(OMe)-OMe.HCl

DL-Glu(OMe)-OMe.HCl

Dimethyl <small>DL</small>-Glutamate Hydrochloride

H-DL-Glu(Ome)-Ome

1,5-dimethyl 2-aminopentanedioate hydrochloride

DimethylDL-GlutamateHydrochloride&gt

utamate HydrochL

imethyl2-aminopentanedioate,hydrochloride

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP

Dimethyl DL-Glutamate (hydrochloride), 10 mM in DMSO

13515-99-6

Amino Acids (C-Protected)

Amino Acid Methyl Esters

Protected & Labeled Amino Acids

Amino Acid Methyl Esters

Amino Acids

Amino Acids (C-Protected)

Biochemistry