4-METHOXYCINNAMIC ACID

Product Name: 4-METHOXYCINNAMIC ACID
CAS No.: 943-89-5
Chemical Name: 4-METHOXYCINNAMIC ACID
Synonyms: PMCA;AKOS B000181;AKOS BB/0034;AKOS BBS-00000769;TIMTEC-BB SBB005717;RARECHEM BK HC T257;OTAVA-BB BB0123400502;4-Methoxycinnamic acid;LABOTEST-BB LT00108121;O-METHYL-P-CUMARIC ACID
CBNumber: CB1152939
Molecular Formula: C10H10O3
Formula Weight: 178.18
MOL File: 943-89-5.mol

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4-METHOXYCINNAMIC ACID Property

Melting point:: 173.5 °C(lit.)
Boiling point:: 342.6±17.0 °C(Predicted)
Density: 1.195±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in ethanol, ethyl acetate and other organic solvents.
pka: 4.60±0.10(Predicted)
form: powder to crystal
color: White to Almost white
BRN: 510468
InChIKey: AFDXODALSZRGIH-QPJJXVBHSA-N
LogP: 1.264 (est)
CAS DataBase Reference: 943-89-5(CAS DataBase Reference)
NIST Chemistry Reference: 2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5)
EPA Substance Registry System: 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: UD3391300
F: 8
TSCA: Yes
HS Code: 2918.29.7500
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M0576
Product name: trans-4-Methoxycinnamic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: M0576
Product name: trans-4-Methoxycinnamic Acid
Purity: >98.0%(GC)(T)
Packaging: 100g
Price: $77
Updated: 2024/03/01

Alfa Aesar

Product number: A13870
Product name: trans-4-Methoxycinnamic acid
Purity: 98%
Packaging: 10g
Price: $21.65
Updated: 2024/03/01

Alfa Aesar

Product number: A13870
Product name: trans-4-Methoxycinnamic acid
Purity: 98%
Packaging: 50g
Price: $80.65
Updated: 2024/03/01

Alfa Aesar

Product number: A13870
Product name: trans-4-Methoxycinnamic acid
Purity: 98%
Packaging: 250g
Price: $336.65
Updated: 2024/03/01

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4-METHOXYCINNAMIC ACID Chemical Properties,Usage,Production

Uses

Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.

Preparation

4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).
Synthesis of 4-methoxycinnamic acid

Definition

ChEBI: 4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid.

Purification Methods

Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]

4-METHOXYCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHOXYCINNAMIC ACID Suppliers

Americas 1 Canada 1 China 160 Europe 3 France 1 Germany 4 India 7 Japan 2 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 4 United States 19 USA 1 Global 206

HBCChem, Inc.

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MP Biomedicals, Inc.

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View Lastest Price from 4-METHOXYCINNAMIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-METHOXYCINNAMIC ACID 943-89-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-28

Shaanxi Dideu Medichem Co. Ltd

Product: (E)-4-Methoxycinnamic Acid 943-89-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-01-20

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Product: 4-methoxycinnamicacid 943-89-5
Price: US $25.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2021-12-31

943-89-5, 4-METHOXYCINNAMIC ACIDRelated Search:

trans-Cinnamic acid Octyl 4-methoxycinnamate Fumaric acid TRANS-1,2-DIAMINOCYCLOHEXANE-N,N,N',N'-TETRAACETIC ACID MONOHYDRATE trans-Ferulic acid TRANS-ACONITIC ACID trans-2-Hexenoic acid 4-Methoxycinnamic acid

4-METHOXYCINNAMIC ACID ABOUT 98%

trans-4-Methoxycinnamic acid, 98+%

(E)-4-Methoxycinnamic acid

4-Methoxy-trans-cinnamic acid

p-Methoxy-trans-cinnamic acid

4-Methoxycinnamic acid >=98.0% (GC)

trans-4-MethoxyClnnamic acid

4-Methoxycinnamic acid

RARECHEM BK HC T257

TIMTEC-BB SBB005717

PMCA

O-METHYL-P-COUMARIC ACID

O-METHYL-P-CUMARIC ACID

OTAVA-BB BB0123400502

TRANS-3-(4-METHOXYPHENYL)ACRYLIC ACID

METHOXYCINNAMIC ACID,4-

AKOS B000181

AKOS BB/0034

AKOS BBS-00000769

LABOTEST-BB LT00108121

(E)-3-(4-METHOXYPHENYL)ACRYLIC ACID

3-(4-METHOXY-PHENYL)-ACRYLIC ACID

(2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID

(E)-p-methoxycinnamic acid

2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-

2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)-

(E)-4-MethoxycinnamicAci

trans-O-Methyl-p-coumaric Acid

(E)-3-(4-methoxyphenyl)prop-2-enoic acid

943-89-5 RARECHEM BK HC T257

(E)-3-(4-Methoxyphenyl)acrylic acid (compound 3)

943-89-5

786-13-1

Exciton Chirality CD Method (for Hydroxyl Groups)

Absolute Conefiguration Determination (Exciton Chirality CD Method)

Chalcones, etc. (Building Blocks for Liquid Crystals)

Enantiomer Excess & Absolute Conefiguration Determination

Building Blocks for Liquid Crystals

Carboxylic Acids

Carbonyl Compounds

C10

Building Blocks

Organic Building Blocks

Benzenes

943-89-5