ChemicalBook > CAS DataBase List > 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

Product Name
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
CAS No.
946387-07-1
Chemical Name
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms
PM-0016;RN 1734;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
CBNumber
CB11529521
Molecular Formula
C14H22Cl2N2O2S
Formula Weight
353.31
MOL File
946387-07-1.mol
More
Less

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Property

storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
Yellow solid
color 
white to off-white
More
Less

Safety

WGK Germany 
nwg
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0658
Product name
RN-1734
Purity
≥98% (HPLC)
Packaging
5mg
Price
$84.1
Updated
2024/03/01
Sigma-Aldrich
Product number
616520
Product name
TRPV4 Antagonist I, RN-1734
Packaging
10mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
24205
Product name
RN-1734
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
24205
Product name
RN-1734
Purity
≥98%
Packaging
10mg
Price
$95
Updated
2024/03/01
Sigma-Aldrich
Product number
R0658
Product name
RN-1734
Purity
≥98% (HPLC)
Packaging
25mg
Price
$335
Updated
2024/03/01
More
Less

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties,Usage,Production

Uses

RN 1734 is a novel TRPV4 modulator.

Uses

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

General Description

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).

Biological Activity

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

Biochem/physiol Actions

RN-1734 is a selective TRPV4 antagonist.

storage

+4°C

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Suppliers

China 59 India 1 United Kingdom 4 United States 12 Global 76
Key Organics Limited/Bionet Research
Tel
--
Fax
--
Email
enquiries@keyorganics.ltd.uk
Country
United Kingdom
ProdList
6663
Advantage
50
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74

946387-07-1, 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamideRelated Search:

5-METHYL-N,N-DIMETHYLTRYPTAMINE Cumene N-Isopropylacrylamide N-Isopropylbenzylamine N-Methyl-2-pyrrolidone RN-1 (hydrochloride) RKI1447 RN486

  • 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
  • RN 1734
  • 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734)
  • 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide
  • TRPV4 Antagonist I, RN-1734
  • TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem
  • 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
  • Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
  • RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide)
  • PM-0016
  • RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734
  • 946387-07-1