2-CHLORO-5-HYDROXYBENZOIC ACID
- Product Name
- 2-CHLORO-5-HYDROXYBENZOIC ACID
- CAS No.
- 56961-30-9
- Chemical Name
- 2-CHLORO-5-HYDROXYBENZOIC ACID
- Synonyms
- Benzoic acid, 2-chloro-5-hydroxy-;3-Carboxy-4-chlorophenol;2-Chloro-5-hydroxybenzoic;2-Chloro-5-hyroxybenzoicacid;2-CHLORO-5-HYDROXYBENZOIC ACID;2-Chloro-5-hydroxybenzoic Acid >2-Chloro-5-hydroxybenzoic acid 98%;2-Chloro-5-hydroxybenzene carboxylic acid
- CBNumber
- CB1156139
- Molecular Formula
- C7H5ClO3
- Formula Weight
- 172.57
- MOL File
- 56961-30-9.mol
2-CHLORO-5-HYDROXYBENZOIC ACID Property
- Melting point:
- 178-180°C
- Boiling point:
- 364.5±27.0 °C(Predicted)
- Density
- 1.536±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.78±0.25(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 56961-30-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2724
- Product name
- 2-Chloro-5-hydroxybenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $137
- Updated
- 2025/07/31
- Product number
- C349490
- Product name
- 2-Chloro-5-hydroxybenzoic Acid
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J98483
- Product name
- 2-Chloro-5-hydroxybenzoic Acid
- Packaging
- 10g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- FC55540
- Product name
- 2-Chloro-5-hydroxybenzoic acid
- Packaging
- 2g
- Price
- $59.3
- Updated
- 2021/12/16
- Product number
- FC55540
- Product name
- 2-Chloro-5-hydroxybenzoic acid
- Packaging
- 5G
- Price
- $121.3
- Updated
- 2021/12/16
2-CHLORO-5-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production
Uses
2-Chloro-5-hydroxybenzoic Acid acts as a reagent for the synthesis, structure-activity relationship, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.
Synthesis
89-54-3
56961-30-9
General procedure for the synthesis of 2-chloro-5-hydroxybenzoic acid from 5-amino-2-chlorobenzoic acid: aqueous sodium nitrite (90 mL, 0.5 M) was slowly added to a stirring suspension of 5-amino-2-chlorobenzoic acid (16) (5.01 g, 29.6 mmol) and sulfuric acid (6.00 mL, 0.167 mol) at 0 °C. During addition, the reaction temperature was maintained between 0 and 5 °C. After addition, stirring was continued in an ice bath for 1 hour. Subsequently, the reaction mixture was diluted with water (900 mL) and stirred under reflux conditions for 30 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 500 mL). The organic phases were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the light brown solid product 17 (4.97 g, 98% yield). The melting point of the product was 165-168 °C; IR (ZnSe) showed absorption peaks located at 3311, 2920, 2598, 1676, 1599, 1573, 1474, 1447, 1228, 826 cm-1 ; 1H NMR (300 MHz, MeOD) chemical shifts were δ 7.26 (1H, d, J = 8.7 Hz), 7.23 (1H, d, J = 3.0 Hz), 6.89 (1H, dd, J = 3.0 and 8.7 Hz) ppm, no 2xOH signal observed; 13C NMR (75 MHz, MeOD) chemical shifts were δ169.1, 157.4, 132.7, 132.8, 123.8, 120.7, 116.2 ppm; LRMS (-) ESI) showed m/z 171 ([M-H]-, 100%), 127 ([M-CO2H]-, 36%).
References
[1] Tetrahedron, 2018, vol. 74, # 12, p. 1207 - 1219
[2] Patent: WO2008/64432, 2008, A1. Location in patent: Page/Page column 58
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 13, p. 3720 - 3723
[4] Monatshefte fuer Chemie, 1921, vol. 42, p. 80
[5] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1924, vol. 54, p. 832
2-CHLORO-5-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-5-HYDROXYBENZOIC ACID manufacturers
- Product
- 2-CHLORO-5-HYDROXYBENZOIC ACID 56961-30-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-08
- Product
- 2-CHLORO-5-HYDROXYBENZOIC ACID 56961-30-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-CHLORO-5-HYDROXYBENZOIC ACID 56961-30-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09