METHYL 3-CHLORO-4-HYDROXYBENZOATE

Product Name: METHYL 3-CHLORO-4-HYDROXYBENZOATE
CAS No.: 3964-57-6
Chemical Name: METHYL 3-CHLORO-4-HYDROXYBENZOATE
Synonyms: RARECHEM AL BF 0232;Methyl 3-chloro-4-hydroxybenzoat;METHYL-4-HYDROXY-3-CHLOROBENZOATE;METHYL 3-CHLORO-4-HYDROXYBENZOATE;3-chloro-4-hydroxy-2-methylbenzoate;Methyl 3-chloro-4-hydroxybenzoate-98%;3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER;4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER;Benzoic acid, 3-chloro-4-hydroxy-, methyl ester;4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER 97%
CBNumber: CB7137637
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 3964-57-6.mol

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METHYL 3-CHLORO-4-HYDROXYBENZOATE Property

Melting point:: 108-110°C
Boiling point:: 284.9±20.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 6.89±0.18(Predicted)
Appearance: White to off-white Solid
BRN: 2641291
InChI: InChI=1S/C8H7ClO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3
InChIKey: ZSBIMTDWIGWJPW-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(O)C(Cl)=C1
CAS DataBase Reference: 3964-57-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3513
Product name: Methyl 3-Chloro-4-hydroxybenzoate
Purity: min. 98.0 %
Packaging: 5G
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: M3513
Product name: Methyl 3-Chloro-4-hydroxybenzoate
Purity: min. 98.0 %
Packaging: 25G
Price: $210
Updated: 2025/07/31

TRC

Product number: M312770
Product name: Methyl3-Chloro-4-hydroxybenzoate
Packaging: 100g
Price: $440
Updated: 2021/12/16

Matrix Scientific

Product number: 088309
Product name: Methyl 5-chloro-6-hydroxynicotinate
Packaging: 1g
Price: $234
Updated: 2021/12/16

AK Scientific

Product number: C309
Product name: Methyl3-chloro-4-hydroxybenzoate
Packaging: 100g
Price: $399
Updated: 2021/12/16

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METHYL 3-CHLORO-4-HYDROXYBENZOATE Chemical Properties,Usage,Production

Uses

Methyl 3-Chloro-4-hydroxybenzoate is a reagent in the preparation of alkylidene hydrazides as human glucagon receptor antagonists for the treatment of hyperglycemia and diabetes.

Synthesis

67-56-1

3964-58-7

3964-57-6

1. Sulfuric acid (3 mL, 56.3 mmol) was added to a solution of 3-chloro-4-hydroxybenzoic acid (1.0 g, 5.8 mmol) in methanol (30 mL). 2. The reaction mixture was stirred at 60 °C for 12 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature and the methanol was removed under vacuum. 4. The residue was partitioned between saturated sodium bicarbonate solution and ethyl acetate (3 x 30 mL). 5. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to afford methyl 3-chloro-4-hydroxybenzoate (0.9 g, 83% yield) as a white solid. 6. The product was characterized by ESI-MS and NMR: ESI-MS m/z calculated 186.5, measured 187.5 (M + 1)+; retention time: 1.17 min (3 min run). ,2.2H, 1H), 7.06 (d, J = 8.8 Hz, 1H) and 3.90 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1887 - 1891
[2] Patent: WO2012/125613, 2012, A1. Location in patent: Page/Page column 145
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 7, p. 902 - 907
[4] Chemische Berichte, 1897, vol. 30, p. 1477
[5] Patent: US2009/298894, 2009, A1. Location in patent: Page/Page column 63

METHYL 3-CHLORO-4-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3-CHLORO-4-HYDROXYBENZOATE Suppliers

Canada 1 China 142 Germany 7 India 10 Slovakia 1 Switzerland 2 United Kingdom 14 United States 29 Global 206

INTATRADE GmbH

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Accela ChemBio Co.,Ltd.

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Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from METHYL 3-CHLORO-4-HYDROXYBENZOATE manufacturers

Career Henan Chemical Co

Product: METHYL 3-CHLORO-4-HYDROXYBENZOATE 3964-57-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

3964-57-6, METHYL 3-CHLORO-4-HYDROXYBENZOATERelated Search:

Methyl malonyl chloride 3-Chloro-4-fluoro Methyl benzoate METHYL 3-CHLORO-4-METHOXYBENZOATE METHYL 3-CHLORO-4-HYDROXYBENZOATE METHYL 3,5-DICHLORO-4-HYDROXYBENZOATE ETHYL 3,5-DICHLORO-4-HYDROXYBENZOATE METHYL 5-CHLORO-2-HYDROXYBENZOATE Methyl 4-chloro-2-hydroxybenzoate Methyl 3,5-dibromo-4-chlorosalicylate METHYL 2-CHLORO-5-HYDROXYBENZOATE Methyl 3-amino-5-chloro-2-hydroxybenzoate 3-CHLORO-4-HYDROXYBENZOIC ACID flambamycin 3,5-DICHLORO-4-METHOXYBENZOIC ACID ETHYL ESTER avilamycin A METHYL 3,5-DICHLORO-4-METHOXYBENZOATE ETHYL 3-CHLORO-4-METHOXYBENZOATE 3,5-DICHLORO-4-HYDROXYBENZOIC ACID PROPYL ESTER

4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER

3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER

METHYL 3-CHLORO-4-HYDROXYBENZOATE

METHYL-4-HYDROXY-3-CHLOROBENZOATE

RARECHEM AL BF 0232

3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER 97%

4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER 97%

3-chloro-4-hydroxy-2-methylbenzoate

Benzoic acid, 3-chloro-4-hydroxy-, methyl ester

Methyl 3-chloro-4-hydroxybenzoate-98%

Methyl 3-chloro-4-hydroxybenzoat

3964-57-6

ClC6H3OHCOOCH3

Aromatic Esters