Methyl malonyl chloride
- Product Name
- Methyl malonyl chloride
- CAS No.
- 37517-81-0
- Chemical Name
- Methyl malonyl chloride
- Synonyms
- AURORA KA-3053;TwoMethylchloride;Mehtyl Malonyl Chloride;METHYL MALONYL CHLORIDE;MethylMalonylChloride>METHYL CHLOROFORMYLACETATE;Methyl malonyl chloride 97%;Methyl malonyl chloride,97%;Methylemalonyl chloride, 97%;METHYL 3-CHLORO-3-OXOPROPIONATE
- CBNumber
- CB3683727
- Molecular Formula
- C4H5ClO3
- Formula Weight
- 136.53
- MOL File
- 37517-81-0.mol
Methyl malonyl chloride Property
- Boiling point:
- 57-59 °C/12 mmHg (lit.)
- Density
- 1.273 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.432(lit.)
- Flash point:
- 176 °F
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform, Ethyl Acetate
- pka
- 9.33±0.46(Predicted)
- form
- Liquid
- color
- Colorless
- Specific Gravity
- 1.275
- Water Solubility
- Reacts with water.
- Sensitive
- Lachrymatory
- BRN
- 1754078
- InChI
- 1S/C4H5ClO3/c1-8-4(7)2-3(5)6/h2H2,1H3
- InChIKey
- UTBCRHAMJFMIIR-UHFFFAOYSA-N
- SMILES
- COC(=O)CC(Cl)=O
- CAS DataBase Reference
- 37517-81-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Methyl malonyl chloride(37517-81-0)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-36/37
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 8-10-19
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29171900
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Eye Dam. 1
Skin Corr. 1B
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 164011
- Product name
- Methyl 3-chloro-3-oxopropionate
- Purity
- 97%
- Packaging
- 5g
- Price
- $68.5
- Updated
- 2025/07/31
- Product number
- 164011
- Product name
- Methyl 3-chloro-3-oxopropionate
- Purity
- 97%
- Packaging
- 25g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- M2315
- Product name
- Methyl Malonyl Chloride
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- M2315
- Product name
- Methyl Malonyl Chloride
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- 63406
- Product name
- Methyl malonyl chloride
- Purity
- purum, ≥97.0% (AT)
- Packaging
- 10ml
- Price
- $130.2
- Updated
- 2025/07/31
Methyl malonyl chloride Chemical Properties,Usage,Production
Chemical Properties
Clear light yellow to yellow liquid
Uses
Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.
General Description
Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.
Synthesis
Methylmalonyl chloride can be obtained by reacting hydrogen methylmalonate with oxalyl chloride. Take out the 100 mL clean flask from the oven and cool it to room temperature under argon, add 5 mL of methylene chloride and 1.0 g (8.5 mmol) of hydrogen methylmalonate to the reaction flask and add a drop of DMF during stirring, add 1.2 g (9.4 mmol) of oxalyl chloride to the reaction flask slowly in an ice bath for 5 minutes, withdraw the ice bath, and react for 2 hours at room temperature, then evaporate and concentrate the mixture to obtain methylmalonyl chloride with a rotary evaporator. The reaction was carried out for 2 hours at room temperature and concentrated by rotary evaporator to obtain methyl malonate chloride.
Methyl malonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl malonyl chloride manufacturers
- Product
- Methyl malonyl chloride 37517-81-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- Methyl malonyl chloride 37517-81-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-11
- Product
- Methyl malonyl chloride 37517-81-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-28