Di-tert-Butyl malonate
- Product Name
- Di-tert-Butyl malonate
- CAS No.
- 541-16-2
- Chemical Name
- Di-tert-Butyl malonate
- Synonyms
- MALONIC ACID DI-TERT-BUTYL ESTER;DI-T-BUTYL MALONATE;Di-tert-Butyl malote;Di-tert-Butyl malona;DI-TERT-BUTYL MALONATE;Di-tetr butyl malonate;Di-tert-butylMalonate>Di-t-butyl malonate, 98+%;Di-tert-butylmalonate,98+%;Malonic acid di-tert-butyl
- CBNumber
- CB1156179
- Molecular Formula
- C11H20O4
- Formula Weight
- 216.27
- MOL File
- 541-16-2.mol
Di-tert-Butyl malonate Property
- Melting point:
- -7--6 °C (lit.)
- Boiling point:
- 110-111 °C/22 mmHg (lit.)
- Density
- 0.966 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.418(lit.)
- Flash point:
- 88 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- form
- Liquid
- pka
- 11.87±0.46(Predicted)
- color
- Clear colorless to slightly yellow
- Water Solubility
- It is hardly soluble in water.
- Merck
- 14,3034
- BRN
- 1781766
- InChI
- 1S/C11H20O4/c1-10(2,3)14-8(12)7-9(13)15-11(4,5)6/h7H2,1-6H3
- InChIKey
- CLPHAYNBNTVRDI-UHFFFAOYSA-N
- SMILES
- CC(C)(C)OC(=O)CC(=O)OC(C)(C)C
- CAS DataBase Reference
- 541-16-2(CAS DataBase Reference)
- NIST Chemistry Reference
- di-tert-Butyl malonate(541-16-2)
- EPA Substance Registry System
- Propanedioic acid, bis(1,1-dimethylethyl) ester (541-16-2)
Safety
- Risk Statements
- 36/37/38-24/25
- Safety Statements
- 23-24/25
- WGK Germany
- 3
- TSCA
- TSCA listed
- HS Code
- 29171910
- Storage Class
- 10 - Combustible liquids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P321Specific treatment (see … on this label).
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- 254487
- Product name
- Di-tert-butyl malonate
- Purity
- 98%
- Packaging
- 10g
- Price
- $93.6
- Updated
- 2026/03/19
- Product number
- M1522
- Product name
- Di-tert-butyl Malonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $64
- Updated
- 2026/03/19
- Product number
- 446515
- Product name
- Di-tert-Butyl Malonate
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- B692680
- Product name
- Di-tert-butyl malonate
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD33544
- Product name
- Di-tert-butyl malonate
- Packaging
- 50g
- Price
- $70
- Updated
- 2021/12/16
Di-tert-Butyl malonate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Di-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T
Uses
In the preparation of ketones.
Uses
Di-tert-butyl malonate was used in total synthesis of (+/)-actinophyllic acid. It was also employed as precursor for metal-organic chemical vapor deposition of HfO2 and ZrO2 thin films.
Synthesis
Step 1. Malonic acid dichloride: 8.0 g (76.9 mmol) of malonic acid and 30.0 g (0.25 ) of thionyl chloride were first heated at 50C for 3 days, then at 60C for 6 hours. mol) of thionyl chloride were heated at 50C for 3 days, then at 60C for 6 hours. After removing the thionyl chloride in a rotary evaporator, the residue was distilled. Yield: 6.3 g (58%), oil, boiling point 43 C / 12 Torr.
Step 2, Di-tert-butyl malonate: to a solution of 19.5 g (0.26 mol) of anhydrous tert-butanol in 20 mL of anhydrous N,N-dimethylaniline was added dropwise at room temperature a solution dissolved in 6.0 g (0.43 mmol) of malonic acid dichloride in a 15 mL solution of anhydrous CHCl3. Subsequently, the solution was heated at reflux for 4 hours and 40 mL of 3M sulfuric acid was added to the cooled solution. The aqueous phase was extracted three times with 50 mL of ether. The combined organic phases were washed with 20 mL of water, 20 mL of saturated aqueous potassium carbonate solution, and 20 mL of saturated sodium chloride solution. The ether phase was dried over magnesium sulfate and filtered. The solvent was evaporated and the residue was distilled. Yield: 6.0 g (62%), bp 93 C/ 10 Torr.
Di-tert-Butyl malonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Di-tert-Butyl malonate manufacturers
- Product
- Di-tert-Butyl malonate 541-16-2
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- Di-tert-Butyl malonate 541-16-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- Di-tert-Butyl malonate 541-16-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-17