8-BROMO-2-METHYL-QUINOLINE

Uses

Product Name: 8-BROMO-2-METHYL-QUINOLINE
CAS No.: 61047-43-6
Chemical Name: 8-BROMO-2-METHYL-QUINOLINE
Synonyms: 8-Bromoquinaldine;2-Methyl-8-bromoquinoline;8-BROMO-2-METHYL-QUINOLINE;Quinoline, 8-bromo-2-methyl-;8-Bromo-2-methylquinoline >7-Trifluoromethyl-8-hydroxyquinoline;8-BROMO-2-METHYL-QUINOLINE ISO 9001：2015 REACH
CBNumber: CB1157974
Molecular Formula: C10H8BrN
Formula Weight: 222.08
MOL File: 61047-43-6.mol

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8-BROMO-2-METHYL-QUINOLINE Property

Melting point:: 63-65℃
Boiling point:: 132°C/0.1mmHg(lit.)
Density: 1.488
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.17±0.50(Predicted)
color: White to Light yellow
InChI: InChI=1S/C10H8BrN/c1-7-5-6-8-3-2-4-9(11)10(8)12-7/h2-6H,1H3
InChIKey: GQPRZSFQSOEDNV-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2Br)C=CC=1C
CAS DataBase Reference: 61047-43-6

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Safety

HS Code: 2933.49.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3444
Product name: 8-Bromo-2-methylquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: B3444
Product name: 8-Bromo-2-methylquinoline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $226
Updated: 2025/07/31

TRC

Product number: B405250
Product name: 8-Bromo-2-methylquinoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168383
Product name: 8-Bromo-2-methylquinoline
Packaging: 1g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 9135AB
Product name: 8-Bromo-2-methylquinoline
Packaging: 100mg
Price: $72
Updated: 2021/12/16

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8-BROMO-2-METHYL-QUINOLINE Chemical Properties,Usage,Production

Uses

8-Bromo-2-methylquinoline is a quinoline derivative that can be used as a pharmaceutical intermediate.

Synthesis

615-36-1

123-73-9

61047-43-6

To a 6N hydrochloric acid (300 mL) solution of o-bromoaniline (100 g, 0.58 mol) was slowly added trans-2-butenal (81 g, 1.1 mol) at room temperature. The reaction mixture was heated to 100 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature, alkalized to pH 8-9 with ammonium hydroxide solution and subsequently extracted with ether (3 × 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (12:1 to 10:1, v/v) as eluent to afford 8-bromo-2-methylquinoline as a white solid (59 g, 54% yield). Mass spectrometry (ESI) analysis: calculated value for C10H8BrN was 222.1; measured value was 223 [M + H]+.

References

[1] Patent: WO2010/101949, 2010, A1. Location in patent: Page/Page column 116; 117
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 4066 - 4084
[3] Patent: WO2009/80675, 2009, A1. Location in patent: Page/Page column 14
[4] Arkivoc, 2015, vol. 2015, # 3, p. 38 - 51

8-BROMO-2-METHYL-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMO-2-METHYL-QUINOLINE Suppliers

Americas 1 CHINA 102 Europe 1 India 2 Japan 1 Russia 1 United Kingdom 2 United States 6 Global 116

Shanghai RenYue Chemical Technology Co., Ltd.

Tel: 021-62219190; 18321139117
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View Lastest Price from 8-BROMO-2-METHYL-QUINOLINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 8-Bromo-2-methylquinoline 61047-43-6
Price: US $5.90-3.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: 8-Bromo-2-methylquinoline 61047-43-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 8-Bromo-2-methylquinoline 61047-43-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

61047-43-6, 8-BROMO-2-METHYL-QUINOLINERelated Search:

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8-BROMO-2-METHYL-QUINOLINE ISO 9001：2015 REACH

7-Trifluoromethyl-8-hydroxyquinoline

61047-43-6