5-Aminoindan
- Product Name
- 5-Aminoindan
- CAS No.
- 24425-40-9
- Chemical Name
- 5-Aminoindan
- Synonyms
- Aminoindan;AKOS 91137;5-AMINOINDAN;5-INDANAMINE;indan-5-amine;5-AMINOINDANE;5-Indanylamine;indan-5-ylamine;5-Aminoindan,97%;5-AMinoindan 95%
- CBNumber
- CB1160736
- Molecular Formula
- C9H11N
- Formula Weight
- 133.19
- MOL File
- 24425-40-9.mol
5-Aminoindan Property
- Melting point:
- 34-36 °C(lit.)
- Boiling point:
- 247-249 °C745 mm Hg(lit.)
- Density
- 0.9222 (rough estimate)
- refractive index
- 1.4600 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 0-10°C
- pka
- 5.17±0.20(Predicted)
- form
- Crystalline Solid
- color
- Brown
- Water Solubility
- SLIGHTLY SOLUBLE
- BRN
- 2082278
- InChI
- InChI=1S/C9H11N/c10-9-5-4-7-2-1-3-8(7)6-9/h4-6H,1-3,10H2
- InChIKey
- LEWZOBYWGWKNCK-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=C(N)C=C2)CC1
- CAS DataBase Reference
- 24425-40-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Aminoindan(24425-40-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 130877
- Product name
- 5-Aminoindan
- Purity
- 95%
- Packaging
- 10g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- A0991
- Product name
- 5-Aminoindan
- Purity
- >98.0%(GC)(T)
- Packaging
- 10g
- Price
- $103
- Updated
- 2025/07/31
- Product number
- A611885
- Product name
- 5-Aminoindan
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- V1271
- Product name
- 5-Aminoindan
- Packaging
- 25g
- Price
- $371
- Updated
- 2021/12/16
- Product number
- FA04021
- Product name
- 5-Aminoindane
- Packaging
- 50g
- Price
- $225
- Updated
- 2021/12/16
5-Aminoindan Chemical Properties,Usage,Production
Chemical Properties
brown crystalline mass
Uses
5-Aminoindan was used in the synthesis of ligand 18/18 (2-(5-aminoindan)-6-(5-aminoindan)-4-chloro-s-triazine).
Synthesis
41734-55-8
24425-40-9
General procedure for the synthesis of 5-aminoindan from 5-nitroindene: To a solution of EtOAc (20 mL) of 5-nitroindene (80.5 mg, 0.5 mmol) was added 10% Pd/C (catalyst dosage of 20% by mass of 5-nitroindene). The mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the insoluble material was removed by filtration and washed with EtOAc. The filtrate was concentrated to dryness under reduced pressure to give 5-aminoindene (65 mg, 98% yield) as a brown oil. To a solution of 5-aminoindene (150 mg, 0.8 mmol) in thionyl chloride (4 mL) was added a drop of pyridine followed by reflux for 24 hours. At the end of the reaction, the thionyl chloride was removed by distillation to give 5-aminoindene chloride as a light yellow solid, and the product was used directly in the next step of the reaction. A dichloromethane (2 mL) solution of 5-aminoindene chloride was added dropwise to an anhydrous pyridine (2 mL) solution of 5-aminoindene (65 mg, 0.5 mmol) at 0°C. The mixture was stirred at room temperature for 7 h. Methanol was subsequently removed by distillation. The organic layer was treated sequentially with 1N HCl until acidic. The mixture was partitioned between water and EtOAc. The organic layer was washed with saturated brine, dried over anhydrous Na2SO4 and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane/EtOAc = 3/1) to afford the target compound 5-aminoindan (118 mg, 80% yield) as a light yellow solid. Melting point 138~142°C; 1H-NMR: δ8.15 (d, J=6.9Hz, 2H), 7.93 (d, J=8.1Hz, 2H), 7.60 (s, 1H), 7.30 (d, J=8.1Hz, 1H), 7.22 (d, J=7.9Hz, 1H), 3.96 (s, 3H), 2.95-2.89 (m. 4H), 2.13-2.07 (m, 2H); ESI-MS: m/z [M+H]+ 296.
Purification Methods
Distil the indane and then crystallise it from pet ether. [Beilstein 12 I 511, 12 III 2798.]
References
[1] Molecules, 2017, vol. 22, # 1,
[2] Justus Liebigs Annalen der Chemie, 1953, vol. 579, p. 133,151
[3] Journal of the Chemical Society, 1947, p. 95
5-Aminoindan Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminoindan manufacturers
- Product
- 5-Aminoindan 24425-40-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 5-Aminoindan 24425-40-9
- Price
- US $10.00/KG/Tin
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2019-06-27