Isosorbide

Product Name: Isosorbide
CAS No.: 652-67-5
Chemical Name: Isosorbide
Synonyms: (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol;at101;IsMotic;Isosorbide (75% solution, 1 g);ucitoL;isobide;hydronol;Isosorbid;NSC 40725;devicoran
CBNumber: CB1162705
Molecular Formula: C6H10O4
Formula Weight: 146.14
MOL File: 652-67-5.mol

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Isosorbide Property

Melting point:: 60-63 °C (lit.)
alpha: 42 º (c=3, H2O)
Boiling point:: 175°C/2mmHg(lit.)
Density: 1.0945 (rough estimate)
vapor pressure: 0.007Pa at 20℃
refractive index: 45 ° (C=5, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka: 13.17±0.40(Predicted)
form: Crystals, Crystalline Solid or Mass
color: Off-white to light yellow or beige
optical activity: [α]20/D +45.2°, c = 3 in H2O
Water Solubility: Soluble in alcohols, water and ketones.
Sensitive: Hygroscopic
Merck: 14,5224
BRN: 80510
InChIKey: KLDXJTOLSGUMSJ-JGWLITMVSA-N
LogP: -1.39 at 20℃
CAS DataBase Reference: 652-67-5(CAS DataBase Reference)
EPA Substance Registry System: D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

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Safety

Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 2
RTECS: LZ4380000
TSCA: Yes
HS Code: 29349990
Hazardous Substances Data: 652-67-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 329207
Product name: Dianhydro-D-glucitol
Purity: 98%
Packaging: 100g
Price: $91.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1352008
Product name: Isosorbide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 1g
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: I0407
Product name: Isosorbide
Purity: >98.0%(GC)
Packaging: 25g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: I0407
Product name: Isosorbide
Purity: >98.0%(GC)
Packaging: 100g
Price: $54
Updated: 2024/03/01

Alfa Aesar

Product number: A13989
Product name: D-Isosorbide, 98%
Packaging: 50g
Price: $39.3
Updated: 2024/03/01

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Isosorbide Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Isosorbide Preparation Products And Raw materials

Raw materials

D-Sorbitol Sorbitol

Preparation Products

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Isosorbide Suppliers

Americas 1 Belgium 4 Canada 2 China 349 Europe 4 Germany 11 India 18 Japan 4 Malaysia 1 Singapore 2 Slovakia 1 South Korea 1 Spain 2 Switzerland 6 The Netherlands 2 Ukraine 1 United Kingdom 12 United States 35 Global 456

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View Lastest Price from Isosorbide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Isosorbide 652-67-5
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-05-22

Hebei Mujin Biotechnology Co.,Ltd

Product: Isosorbide 652-67-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-06

Baoji Guokang Bio-Technology Co., Ltd.

Product: Isosorbide 652-67-5
Price: US $14.50/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: 1-200mt
Release date: 2021-06-03

652-67-5, IsosorbideRelated Search:

Sorbitol Isosorbide dinitrate D(+)-Glucose Isosorbide dimethyl ether Ammonium carbonate Isosorbide-2-Acetate ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0%,isosorbide2-nitrat Isostearic Acid isononyl alcohol 1,4-ANHYDRO-D-GLUCITOL Octadecyl isocyanate 3-Methyl-1-butanol Isosorbide-13C6 2-Mononitrate,Isosorbide-13C6 2-Nitrate 2-CHLOROETHYL ISOTHIOCYANATE ISOCYANIC ACID FIXATEUR ITC Potassium 2-ethylhexanoate

Dianhydro-D-glucitol 98%

1,4:3,6-DIANHYDRO-D-SORBITOL

1,4:3,6-DIANHYDROGLUCITOL

1,4:3,6-DIANHYDROSORBITOL

1,4:3,6-DIANHYDRO-D-GLUCITOL

D-ISOSORBIDE

DIANHYDRO-D-GLUCITOL

DIANHYDRO-D-SORBITOL

ISOSORBIDE

(3S,3AR,6R,6AR)-HEXAHYDRO-FURO[3,2-B]FURAN-3,6-DIOL

1,4:3,6-dianhydro-d-glucito

Isosorbide, typically 98%

1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide

Isosorbide,98%

Dianhydro-D-glucitol,1,4:3,6-Dianhydro-D-sorbitol, D-Isosorbide

Isosorbide (75% solution, 1 g)

Isosorbide, 98% 100GR

IsMotic

1,4:3,6-Dianhydroglucitol 1,4:3,6-Dianhydrosorbitol

(3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol

1,4,3,6,5-Dianhydrosorbitol

ISOSONBIDE(1,4:3,6-DIANHYDRO-D-SORHITOL)

Isosorbid

D-Glucitol, 1,4:3,6-dianhydro-

D-Glucitol, 1,4:3,6-dianhydro- (9CI)

NSC 40725

1,4,3,6-DIANHYDRO-D-GLUCITOL D-ISOSORBIDE

4:3,6-dianhydro-d-glucito

at101

d-1,4:3,6-dianhydroglucitol

devicoran

hydronol

isobide

Isosorbide,typically98%

Isosorbide Isosorbide

Isosorbide&gt

Isosorbide, 97%, reagent grade

Dianhydro-D-g

ucitoL

Dianhydro-D-gL

Isosorbide USP/EP/BP

Isosorbide Impurity 21

Isosorbide Impurity 22

IsosorbideQ: What is Isosorbide Q: What is the CAS Number of Isosorbide Q: What is the storage condition of Isosorbide Q: What are the applications of Isosorbide

Isosorbide (75% solution, 1 g) (1352008)

1,4：3,6-dianhydro-D-[UL-13C6]glucitol

Isosorbitol

(3S, 3AR, 6R, 6AR) - Hexahydrogen - [3,2-B] furan-3,6-diol)

Isosorbide 1,4:3,6-Dianhydro-D-glucitol

Isosorbide in Acetonitrile

lsosorbide

Isosorbide, 10 mM in DMSO

652-67-5

662-67-5

Carbohydrate Synthesis

Specialty Synthesis

Monosaccharides

Carbohydrates & Derivatives