ChemicalBook > CAS DataBase List > N-Acetyl-L-phenylalanine

N-Acetyl-L-phenylalanine

Product Name
N-Acetyl-L-phenylalanine
CAS No.
2018-61-3
Chemical Name
N-Acetyl-L-phenylalanine
Synonyms
AC-PHE-OH;Ac-L-Phe-OH;Acetylphenylalanine;L-Phenylalanine, N-acetyl-;N-Ac-L-Phe-OH;Ac-L-Phe;NSC 45699;ACETYL-L-PHENYLALANINE;(2S)-2-Acetamido-3-phenylpropanoic acid;H-Ac-Phe-OH
CBNumber
CB1170986
Molecular Formula
C11H13NO3
Formula Weight
207.23
MOL File
2018-61-3.mol
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N-Acetyl-L-phenylalanine Property

Melting point:
171-173 °C(lit.)
alpha 
40 º (c=1,methanol)
Boiling point:
346.25°C (rough estimate)
Density 
1.1878 (rough estimate)
refractive index 
40 ° (C=5, MeOH)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Solubility in methanol (almost transparency). Soluble in acetone and ethanol (20 mg/ ml).
form 
Fine Crystalline Powder or Needles
pka
3.56±0.10(Predicted)
color 
White to off-white
optical activity
[α]22/D +40.0°, c = 1 in methanol
InChIKey
CBQJSKKFNMDLON-JTQLQIEISA-N
CAS DataBase Reference
2018-61-3(CAS DataBase Reference)
NIST Chemistry Reference
L-phenylalanine, n-acetyl-(2018-61-3)
EPA Substance Registry System
L-Phenylalanine, N-acetyl- (2018-61-3)
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Safety

Safety Statements 
24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
857459
Product name
N-Acetyl-L-phenylalanine
Purity
ReagentPlus , 99%
Packaging
1g
Price
$15
Updated
2024/03/01
Sigma-Aldrich
Product number
857459
Product name
N-Acetyl-L-phenylalanine
Purity
ReagentPlus , 99%
Packaging
5g
Price
$78.4
Updated
2024/03/01
TCI Chemical
Product number
A1541
Product name
N-Acetyl-L-phenylalanine
Purity
>99.0%(T)
Packaging
5g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
A1541
Product name
N-Acetyl-L-phenylalanine
Purity
>99.0%(T)
Packaging
25g
Price
$51
Updated
2024/03/01
Alfa Aesar
Product number
B23812
Product name
N-Acetyl-L-phenylalanine, 99%
Packaging
1g
Price
$30.65
Updated
2024/03/01
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N-Acetyl-L-phenylalanine Chemical Properties,Usage,Production

Chemical Properties

white to off-white fine cryst. powder or needles

Uses

It is an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of aspartame. It is applied as an antidepressant.

Uses

N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.

Definition

ChEBI: The N-acetyl derivative of L-phenylalanine.

General Description

N-Acetyl-L-phenylalanine is an acetyl analog of L-phenylalanine. It is widely used as a reactant to synthesize methyl or ethyl esters of N-acetyl-L-phenylalanine, which are employed as versatile building blocks in peptide synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

N-Acetyl-L-phenylalanine is recrystallised from H2O, 20% MeOH/H2O, or CHCl3; dry and store it at 4o. The (DL)-isomer crystallises from H2O, Me2CO, EtOAc, or CHCl3 with m 152-154o and the solubilities in w% at 25o are 0.73 (H2O), 4.3 (Me2CO), 0.79 (EtOAc) and 0.34 (CHCl3) [Kerr & Niemann J Org Chem 23 893 1958, Overby & Ingersoll J Am Chem Soc 73 3363 1951, L: Fu et al. J Am Chem Soc 76 6057 1954, Bender & Glasson J Am Chem Soc 81 1591 1959]. [Beilstein 14 I 238, 4 IV 1575.]

N-Acetyl-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetyl-L-phenylalanine Suppliers

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View Lastest Price from N-Acetyl-L-phenylalanine manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
N-Acetyl-L-phenylalanine 2018-61-3
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Acetyl-L-phenylalanine 2018-61-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Acetyl-L-phenylalanine 2018-61-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

2018-61-3, N-Acetyl-L-phenylalanineRelated Search:

Folic acid Citric acid D-Phenylalanine N-(tert-Butoxycarbonyl)-L-phenylalanine Acetylacetone DL-Phenylalanine Phenprobamate Acetyl coenzyme A sodium salt Ethyl 2-(Chlorosulfonyl)acetate L-Phenylalanine Ascoric Acid Melphalan N-Acetyl-3,5-diiodo-L-tyrosine CHLOROACETYL-L-TYROSINE Aspartame N-Glycyl-L-tyrosine Ethyl N-acetyl-L-tyrosinate hydrate N-CBZ-VAL-TYR METHYL ESTER

  • (2S)-2-Acetamido-3-phenylpropanoic acid
  • (2S)-2-(Acetylamino)-3-phenylpropanoic acid
  • (2S)-2-(Acetylamino)-3-phenylpropionic acid
  • (S)-α-(Acetylamino)benzenepropanoic acid
  • (αS)-α-(Acetylamino)benzenepropanoic acid
  • N-Ac-Phenylalanine
  • L-2-(ACETYLAMINO)-3-PHENYLPROPANOIC ACID
  • AC-PHENYLALANINE
  • AC-PHE-OH
  • ACETYL-L-PHENYLALANINE
  • N-acetyl-3-phenyl-L-alanine
  • N-Acetyl-L-plhenylalanine
  • N-ACETYL-L-PHENYLALANINE SIGMA GRADE
  • N-Acetyl-L-phenylalanine, 99+%
  • (2S)-acetylamino-3-phenyl-propanoic acid
  • N-ACETYL-L-PHENYLALANINE:AC-PHE-OH
  • Ac-L-Phe-OH
  • N-alpha-Actetyl-L-phenylalanine
  • N-ACETYL-L-PHENYLALANINE
  • (2S)-N-ACETYL-L-PHENYLALANINE
  • Ac-L-Phe
  • (2S)-2-acetamido-3-phenylpropanoate
  • H-Ac-Phe-OH
  • N-propionyl leucine
  • (S)-2-AcetaMido-3-phenylpropanoic acid
  • NSC 45699
  • N-Acetyl-L-phenylalanine ReagentPlus(R), 99%
  • Ac-Phe-OH ( N-acetyl-L-phenylalanine )
  • N-Acetyl-L-phenylalanine Vetec(TM) reagent grade, 98%
  • (S)-2-(N-phenylacetamido)propanoic acid
  • Acetyl-L-phenylalanine≥ 99% (HPLC)
  • N-ALPHA-ACETYL-L-PHENYLALANINE
  • Acetylphenylalanine
  • Alanine, N-acetyl-3-phenyl-, L-
  • L-N-Acetylphenylalanine
  • L-Phenylalanine, N-acetyl-
  • N-Acetyl-l-phenalanine
  • n-acetyl-l-phenylalanin
  • N-Ac-L-Phe-OH
  • Amino Acid Impurity 45
  • N-Acetyl-L-phenylalanine &gt
  • N-Acetyl-L-phenylalanine USP/EP/BP
  • N-acetyl-laevo-phenyl alanine
  • 2018-61-3
  • C6H5CH2CHNHCOCH3CO2H
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Phenylalanine
  • Specialty Synthesis
  • chiral
  • Amino Acids Derivatives
  • Amino Acid Derivatives
  • Amino Acids
  • N-Acetyl-Amino acid series
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Phenylalanine
  • Phenylalanine [Phe, F]