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Methyl nicotinate

Product Name
Methyl nicotinate
CAS No.
93-60-7
Chemical Name
Methyl nicotinate
Synonyms
NICOTINIC ACID METHYL ESTER;METHYL PYRIDINE-3-CARBOXYLATE;Nikomet;METHYL 3-PYRIDINECARBOXYLATE;Nicometh;FEMA 3709;Methyl nictinate;METHYL NICOTINATE;AKOS BBS-00004415;Methyl Nicotinatey
CBNumber
CB1173538
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
93-60-7.mol
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Methyl nicotinate Property

Melting point:
42-44 °C (lit.)
Boiling point:
204 °C (lit.)
Density 
1.2528 (rough estimate)
vapor pressure 
0.4 hPa (25 °C)
FEMA 
3709 | METHYL NICOTINATE
refractive index 
1.5323 (estimate)
Flash point:
204 °F
storage temp. 
Store below +30°C.
solubility 
H2O: 0.1 g/mL, clear
form 
Crystals or Crystalline Powder
pka
pKa 3.1 (Uncertain)
color 
White to brownish
Odor
at 10.00 % in dipropylene glycol. warm herbal tobacco
Odor Type
herbal
Water Solubility 
NEGLIGIBLE
JECFA Number
1320
Merck 
14,6100
BRN 
113951
InChIKey
YNBADRVTZLEFNH-UHFFFAOYSA-N
LogP
0.68 at 25℃
CAS DataBase Reference
93-60-7(CAS DataBase Reference)
NIST Chemistry Reference
Methyl nicotinate(93-60-7)
EPA Substance Registry System
Methyl nicotinate (93-60-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
QT1925000
TSCA 
Yes
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W370908
Product name
Methyl Nicotinate
Purity
≥99%, FG
Packaging
5kg
Price
$678
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18713
Product name
Methyl nicotinate
Purity
for synthesis
Packaging
100g
Price
$45.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18713
Product name
Methyl nicotinate
Purity
for synthesis
Packaging
500g
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
72420
Product name
Methyl nicotinate
Purity
puriss., ≥99.0% (GC)
Packaging
100g
Price
$45.8
Updated
2024/03/01
Sigma-Aldrich
Product number
69193
Product name
Methyl nicotinate
Purity
AldrichCPR
Packaging
100mg
Price
$173
Updated
2022/05/15
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Methyl nicotinate Chemical Properties,Usage,Production

Description

Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%).

Chemical Properties

Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor.

Occurrence

Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya.

Uses

Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla.

Definition

ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid.

Application

Methyl nicotinate can be employed as a precursor in the synthesis:
Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.

Preparation

Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate.
Synthesis and antinociceptive activity of methyl nicotinate
DOI:10.4314/jpb.v12i1.8

General Description

Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent.

Side effects

There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes.

Safety

No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248).

Synthesis

Methyl nicotinate is synthesized from Nicotinyl chloride hydrochloride and and Methanol in presence of Pyridine.

Carcinogenicity

No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.

Methyl nicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

Nicorandil 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE Methyl nicotinoylacetate NICOTINIC ACID HYDRAZIDE
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View Lastest Price from Methyl nicotinate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Methyl nicotinate 93-60-7
Price
US $30.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500
Release date
2024-05-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Methyl nicotinate 93-60-7
Price
US $78.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl nicotinate 93-60-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-06-24

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