ChemicalBook > CAS DataBase List > Boc-D-Phenylglycine

Boc-D-Phenylglycine

Product Name: Boc-D-Phenylglycine
CAS No.: 33125-05-2
Chemical Name: Boc-D-Phenylglycine
Synonyms: BOC-D-PHG-OH;BOC-PHG-OH;(R)-2-((tert-butoxycarbonyl)aMino)-2-phenylacetic acid;FS000066;BOC-L-PHG;ST5210539;BOC-L-PHG-OH;Boc-D-PhenyL;BOC-PHENYLGLYCINE;BOC-(PHENYL)GLY-OH
CBNumber: CB1176908
Molecular Formula: C13H17NO4
Formula Weight: 251.28
MOL File: 33125-05-2.mol

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Boc-D-Phenylglycine Property

Melting point:: 88-91 °C
alpha: -142 º (c=1% in ethanol)
Boiling point:: 407.2±38.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
refractive index: -140 ° (C=1, EtOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methanol
form: Crystalline Powder
pka: 3.51±0.10(Predicted)
color: White
optical activity: [α]20/D 141.0±5.0°, c = 1% in ethanol
Water Solubility: Insoluble in water. Slightly soluble in DMSO and methanol.
BRN: 3033982
InChI: InChI=1S/C13H17NO4/c1-13(2,3)18-12(17)14(9-11(15)16)10-7-5-4-6-8-10/h4-8H,9H2,1-3H3,(H,15,16)
InChIKey: KIAPYAZGXJCKQL-UHFFFAOYSA-N
SMILES: C(O)(=O)CN(C(OC(C)(C)C)=O)C1=CC=CC=C1
CAS DataBase Reference: 33125-05-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53101-M
Product name: Boc-D-Phg-OH
Purity: Novabiochem?
Packaging: 5G
Price: $175.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53101-M
Product name: Boc-D-Phg-OH
Purity: Novabiochem?
Packaging: 25g
Price: $1010
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15487
Product name: Boc-D-Phg-OH
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $65
Updated: 2023/06/20

Sigma-Aldrich

Product number: 15487
Product name: Boc-D-Phg-OH
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $135
Updated: 2023/06/20

TCI Chemical

Product number: B3230
Product name: N-(tert-Butoxycarbonyl)-D-2-phenylglycine
Purity: >98.0%(T)
Packaging: 1g
Price: $17
Updated: 2025/07/31

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Boc-D-Phenylglycine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

It is a reagent of choice for assignment of absolute configuration of chiral primary amines by 1H NMR, giving better results than Mosher's acid ((R)-(+)-?-Methoxy-?-(trifluoromethyl)-phenyl-acetic acid. αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-benzeneacetic Acid is D-(+)-2-Phenylglycine with Boc protecting group. (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-benzeneacetic Acid is used as part of a catalyst combination to catalyze regioselective [4 + 2] cycloadditions of β-substituted cyclic enones and polyconjugated malononitriles. It can also be used to catalyze stereoselective preparation of polyfunctional nitrocyclohexene carboxaldehydes.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

875-74-1

33125-05-2

(1) A mixture of (R)-2-amino-2-phenylacetic acid (200 g, 1.32 mol) and potassium carbonate (218 g, 1.58 mol) was dissolved in a solvent mixture of water (2.0 L) and methanol (0.5 L), and cooled to a temperature of less than 10°C. Di-tert-butyl dicarbonate (288 g, 1.32 mol) was added dropwise, and the reaction was stirred at room temperature after the addition. After the addition, the reaction was stirred at room temperature overnight. After completion of the reaction, the pH of the reaction solution was adjusted to 4-5 with 1 N hydrochloric acid, followed by extraction with ethyl acetate (1.0 L × 3). The organic phases were combined, washed with saturated saline (1.0 L × 1), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid product (315 g) in 95% yield.

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 3, p. 968 - 978
[3] Tetrahedron Letters, 1995, vol. 36, # 29, p. 5227 - 5230
[4] Patent: CN104592163, 2016, B. Location in patent: Paragraph 0041; 0042
[5] Patent: CN106748892, 2017, A. Location in patent: Paragraph 0051; 0053; 0054; 0055

Boc-D-Phenylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-D-Phenylglycine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-D-Phenylglycine 33125-05-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Phg-OH 33125-05-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-11

Henan Aochuang Chemical Co.,Ltd.

Product: Boc-D-Phenylglycine 33125-05-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

33125-05-2, Boc-D-PhenylglycineRelated Search:

Glycine D-2-Phenylglycine Anilinoacetic acid 4-Aminophenylacetic acid 4-Hydroxy-D-(-)-2-phenylglycine L-Phenylglycine Tamoxifen Boc-Aib-OH N-Carbobenzyloxyglycine BOC-Glycine 2-Phenoxyethanol Phenoxybenzamine hydrochloride BOC-GLY-LEU-OH BOC-L-PHENYLGLYCINE(BOC-PHG-OH),N-ALPHA-T-BOC-D-PHENYLGLYCINE,N-BOC-D-PHENYLGLYCINE N-BOC-DL-PHENYLGLYCINE BOC-DL-Phg-OH BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDE ESTER,BOC-L-PHENYLGLYCINE N-HYDROXYSUCCINIMIDE ESTER,BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDESTER BOC-D-PHENYLGLYCINE N-HYDROXYSUCCINIMIDE ESTER,BOC-D-PHENYLGLYCINE HYDROXY-SUCCINIMIDE ESTER,BOC-D-PHENYLGLYCINE HYDROXY-SUCCINIMIDESTER

Boc-(R)-2-aminobenzeneacetic acid

N-(tert-Butoxycarbonyl)-D-2-phenylglycine

N-Boc-D-2-phenylglycine

N-(tert-butoxycarbonyl)-D-alpha-phenylglycine

N-Boc-D-2-phenylglycine Boc-D-Phg-OH

(R)-2-((tert-butoxycarbonyl)aMino)-2-phenylacetic acid

N-Boc-D-phenylglycine (Boc-D-Phg-OH)

BOC-(PHENYL)GLY-OH

BOC-PHG-OH

BOC-L-PHG

BOC-L-PHG-OH

BOC-L-PHENYLGLYCINE

BOC-L-ALPHA-PHENYLGLYCINE

BOC-D-PHG-OH

Boc-D-Phg-OH~N-(tert-Butoxycarbonyl)-D-phenylglycine

Boc-D-Phenylycine (Boc-D-Phg-OH) ,99% (HPLC)

BOC-3-CHLORO-PHENYLGLYCINE

(Tert-Butoxy)Carbonyl D-Phg-OH

(R)-2-(Boc-amino)-2-phenylacetic Acid

N-tert-Butoxycarbonyl-D-phenylglycine

Boc-D-Phenylglycine

2-(N-[(2-methylpropan-2-yl)oxy-oxomethyl]anilino)acetic acid

(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-phenylacetic acid

N-Boc-D-a-phenylglycine

(αR)-α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-benzeneacetic Acid

Benzeneacetic acid, a-[[(1,1-diMethylethoxy)carbonyl]aMino]-,(aR)-

Boc-D-Phg-OH, >=99.0% (TLC)

BOC-PHG-OH, >=99.0% (TLC)

2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-phenylacetic acid

2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-phenyl-ethanoic acid

2-[(tert-butoxy-oxomethyl)amino]-2-phenylacetic acid

FS000066

ST5210539

(R)-Boc-2-aminophenylacetic acid

Boc-D-phenylglycine≥ 99% (HPLC)

N-Boc-D-2-phenylglycine,99%e.e.

N-BOC-L-PHENYLGLYCINE

N-ALPHA-T-BOC-L-PHENYLGLYCINE

N-ALPHA-(T-BUTYLOXYCARBONYL)-L-PHENYLGLYCINE

N-ALPHA-T-BUTOXYCARBONYL-T-PHENYLGLYCINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PHENYLGLYCINE

RARECHEM EM WB 0179

(S)-TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID

BOC-PHENYLGLYCINE

N-(tert-Butoxycarbonyl)-D-2-phenylglycine &gt

Boc-D-Phg-OH Boc-D-Phenylglycine

Boc-D-PhenyL

Benzeneacetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)-

Boc-D-α-phenylglycine

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-phenylaceticaci

Boc-D-Phenylglycine USP/EP/BP

N-Boc-D-alfa-phenylglycine

Boc-D-phenylglycine, 98%+

(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid

BOC-D-Phenylglycine extrapure, 99%

N-Boc-D-alpha-phenylglycine, 95%

(R)-N-tert-butoxycarbonyl-2-phenylglycine

Boc-<sc>D</sc>-Phg-OH