ChemicalBook > CAS DataBase List > 3-Indolepropionic acid

3-Indolepropionic acid

Product Name
3-Indolepropionic acid
CAS No.
830-96-6
Chemical Name
3-Indolepropionic acid
Synonyms
PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
CBNumber
CB1183728
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
830-96-6.mol
More
Less

3-Indolepropionic acid Property

Melting point:
~133 °C
Boiling point:
82 °C(lit.)
Density 
0.960 g/mL at 20 °C
vapor density 
2.1 (vs air)
vapor pressure 
33 mm Hg ( 20 °C)
refractive index 
n20/D 1.377(lit.)
Flash point:
53 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
ethanol: soluble50mg/mL, clear, yellow to orange
pka
4.77±0.10(Predicted)
form 
crystalline
color 
light yellow
Water Solubility 
slightly soluble
BRN 
147733
CAS DataBase Reference
830-96-6(CAS DataBase Reference)
NIST Chemistry Reference
Indole-3-propionic acid(830-96-6)
EPA Substance Registry System
1H-Indole-3-propanoic acid (830-96-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
NM1329000
8-10-23
TSCA 
Yes
HS Code 
29339990
Toxicity
LDLo intraperitoneal in mouse: 100mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
57410
Product name
Indole-3-propionic acid
Purity
≥97.0% (T)
Packaging
25g
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
57410
Product name
Indole-3-propionic acid
Purity
≥97.0% (T)
Packaging
100g
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
220027
Product name
3-Indolepropionic acid
Purity
ReagentPlus , 99%
Packaging
1g
Price
$30.7
Updated
2024/03/01
Sigma-Aldrich
Product number
57400
Product name
Indole-3-propionic acid
Purity
≥99.0% (T)
Packaging
5G
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
220027
Product name
3-Indolepropionic acid
Purity
ReagentPlus , 99%
Packaging
10g
Price
$89.7
Updated
2024/03/01
More
Less

3-Indolepropionic acid Chemical Properties,Usage,Production

Description

Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.

Chemical Properties

pale yellow to yellow crystalline powder

Uses

3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.

Uses

Reactant for preparation of:

  • Fluorescent analogues of strigolactones
  • Anti-tumor agents
  • Melanocortin receptors ligands
  • Immunosuppressive agents
  • Iinhibitors of hepatitis C virus
  • Histamine H4 receptor agonists
  • NR2B/NMDA receptor antagonists
  • CB1 antagonist for the treatment of obesity
  • Antibacterial agents
  • Inhibitor of TGF-β receptor binding
Indole-3-propionic acid may be used in the synthesis of oxindole-3-propionic acid via reaction with N-bromosuccinimide in acetic acid followed by treatment with H2/Pd catalyst.

Definition

ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3159, 1984 DOI: 10.1016/S0040-4039(01)90997-9

General Description

3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.

Biochem/physiol Actions

Studied as an adjunct to improve perfusion after liver transplant.

Purification Methods

Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]

3-Indolepropionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Indolepropionic acid Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
Suzhou Kaiyuan Minsheng Sci&Tech Corp. Ltd.
Tel
0512-62889106
Fax
0512-62889106
Email
business@minshengpharm.com
Country
China
ProdList
110
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
13761588971 13761588971
Fax
021 51613951
Email
vivian.zhu@3wpharm.com
Country
China
ProdList
9840
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Changzhou Book Chemical Co., Ltd.
Tel
0519-68780180 13775119556
Fax
0519-68780180
Email
bookchem@126.com
Country
China
ProdList
482
Advantage
62
Shanghai Nuohey Chemical Co., Ltd.
Tel
021-52212593 13761626812
Fax
+86 (21) 51062076
Email
sales@nuohey.com
Country
China
ProdList
10703
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4648
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
933
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9442
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4171
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4576
Advantage
55
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2867
Advantage
52
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2485
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9910
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41132
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2931
Advantage
58
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2549
Advantage
58
More
Less

View Lastest Price from 3-Indolepropionic acid manufacturers

Hebei Duling International Trade Co. LTD
Product
3-Indolepropionic acid 830-96-6
Price
US $9.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2022-12-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Indolepropionic acid 830-96-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2023-01-05
Hebei Mojin Biotechnology Co., Ltd
Product
3-Indolepropionic acid 830-96-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06

830-96-6, 3-Indolepropionic acidRelated Search:


  • 2-HYDROXYPROPANE
  • 2-PPROPANOL
  • 3-(1H-INDOL-3-YL)PROPANOIC ACID
  • 3-(1H-INDOL-3-YL)-PROPIONIC ACID
  • 3-(3-INDOLYL)PROPANOIC ACID
  • 3-(3-INDOLYL)-PROPIONIC ACID
  • AKOS BBS-00006584
  • AKOS BBS-00004245
  • 3-INDOLEPROPIONIC ACID
  • DIMETHYLCARBINOL
  • INDOLEPROPIONIC ACID
  • INDOLE-3-PROPIONIC ACID
  • INDOLE 3-PROPANOIC ACID
  • ISO-PROPYL RUBBING ALCOHOL
  • ISOPROPANE
  • ISOPROPANO
  • ISOPROPANOL ALCOHOL
  • LABOTEST-BB LT00044477
  • FEMA 2929
  • PROPAN-2-OL
  • RUBBING ALCOHOL
  • TIMTEC-BB SBB000276
  • SEC-PROPYL ALCOHOL
  • beta-indolepropionicacid
  • Indolyl-3-propionicacid
  • Ipa (auxin)
  • ISO-PRORYL ALCOHOL(IPA)
  • ALCOHOL ISOPROPYL USP ANYHDROUS
  • ISO PRORYL ALCOHOL
  • ISO PROPYLE ALCOHOL
  • Ethyl #niso-nicotinate
  • INDOLE-3-PROPIONIC ACID PLANT CELL*CULTU RE TESTED
  • 3-(3-INDOLYL)-PROPIONIC ACID PESTANAL, 2
  • Indole-3-PropionicAcid(Ipa)98%Min
  • Indole-3-PropionicAcidForBiochemistry
  • INDOL33YLPROPIONICACID
  • 3-(Indol-3-yl)propanoic acid
  • IPA (Isopropyl Alcohol), 70% v/v
  • ISOPROPYL ALCOHO
  • ISOPROPYL LACOHOL
  • ISO PROPYL ALCOHOL ( IPA )
  • 3-(indol-3-yl)propionic acid
  • JACS-830-96-6
  • 1H-Indole-3-propanoic acid
  • 1h-indole-3-propanoicacid
  • 1H-Indole-3-propionic acid
  • 1h-indole-3-propionicacid
  • 3-(2-Carboxyethyl)-1H-indole
  • 3-(3-Indole)propionic acid
  • 3-(3-Indoly)propionicacid
  • 3-Indolylpropionicacid
  • IPA, 3-Indole propionic acid
  • 3-Indolepropionic acid, 99% 10GR
  • 3-(1H-Indazol-1-yl)propanoic acid
  • 3-Indole propionic acid (IPA)
  • Indole-3-propionic acid,3-(3-Indolyl)propanoic acid, 3-(3-Indolyl)propionic acid, IPA
  • 3-Indolepropionic ac
  • beta-(3-Indolyl)propionic acid