3-Indolepropionic acid
- Product Name
- 3-Indolepropionic acid
- CAS No.
- 830-96-6
- Chemical Name
- 3-Indolepropionic acid
- Synonyms
- PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
- CBNumber
- CB1183728
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 830-96-6.mol
3-Indolepropionic acid Property
- Melting point:
- ~133 °C
- Boiling point:
- 82 °C(lit.)
- Density
- 0.960 g/mL at 20 °C
- vapor density
- 2.1 (vs air)
- vapor pressure
- 33 mm Hg ( 20 °C)
- refractive index
- n20/D 1.377(lit.)
- Flash point:
- 53 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- ethanol: soluble50mg/mL, clear, yellow to orange
- pka
- 4.77±0.10(Predicted)
- form
- crystalline
- color
- light yellow
- Water Solubility
- slightly soluble
- BRN
- 147733
- CAS DataBase Reference
- 830-96-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Indole-3-propionic acid(830-96-6)
- EPA Substance Registry System
- 1H-Indole-3-propanoic acid (830-96-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- RTECS
- NM1329000
- F
- 8-10-23
- TSCA
- Yes
- HS Code
- 29339990
- Toxicity
- LDLo intraperitoneal in mouse: 100mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 57410
- Product name
- Indole-3-propionic acid
- Purity
- ≥97.0% (T)
- Packaging
- 25g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 57410
- Product name
- Indole-3-propionic acid
- Purity
- ≥97.0% (T)
- Packaging
- 100g
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 220027
- Product name
- 3-Indolepropionic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 1g
- Price
- $30.7
- Updated
- 2024/03/01
- Product number
- 57400
- Product name
- Indole-3-propionic acid
- Purity
- ≥99.0% (T)
- Packaging
- 5G
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 220027
- Product name
- 3-Indolepropionic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 10g
- Price
- $89.7
- Updated
- 2024/03/01
3-Indolepropionic acid Chemical Properties,Usage,Production
Description
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.
Chemical Properties
pale yellow to yellow crystalline powder
Uses
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.
Uses
Reactant for preparation of:
- Fluorescent analogues of strigolactones
- Anti-tumor agents
- Melanocortin receptors ligands
- Immunosuppressive agents
- Iinhibitors of hepatitis C virus
- Histamine H4 receptor agonists
- NR2B/NMDA receptor antagonists
- CB1 antagonist for the treatment of obesity
- Antibacterial agents
- Inhibitor of TGF-β receptor binding
Definition
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 3159, 1984 DOI: 10.1016/S0040-4039(01)90997-9
General Description
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.
Biochem/physiol Actions
Studied as an adjunct to improve perfusion after liver transplant.
Purification Methods
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]
3-Indolepropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Indolepropionic acid Suppliers
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View Lastest Price from 3-Indolepropionic acid manufacturers
- Product
- 3-Indolepropionic acid 830-96-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2023-01-05
- Product
- 3-Indolepropionic acid 830-96-6
- Price
- US $196.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1-20mt
- Release date
- 2021-06-08
- Product
- 3-Indolepropionic acid 830-96-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-01